Understanding quantitative genetic variation

Nature Reviews Genetics

Volumn 3, Issue 1, 2002, Pages 11-21

  Barton, Nicholas H ^a   Keightley, Peter D ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

EPISTASIS; EVOLUTION; GENETIC MODEL; GENETIC VARIABILITY; HUMAN; INHERITANCE; MARKER GENE; NATURAL SELECTION; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE GENETICS; QUANTITATIVE TRAIT LOCUS; REVIEW;

ANIMALS; CHROMOSOME MAPPING; EVOLUTION, MOLECULAR; GENETIC MARKERS; HUMANS; LINKAGE (GENETICS); QUANTITATIVE TRAIT, HERITABLE; SELECTION (GENETICS); VARIATION (GENETICS);

EID: 0036245475     PISSN: 14710056     EISSN: None     Source Type: Journal    
DOI: 10.1038/nrg700     Document Type: Review

References (118)

1. Evolutionary quantitative genetics: How little do we know?
2. Comparing evolvability and variability of quantitative traits
3. Deleterious mutations, apparent stabilising selection and the maintenance of quantitative variation
4. The strength of phenotypic selection in natural populations
5. The correlation between relatives on the supposition of Mendelian inheritance
6. Rates of change in quantitative traits from fixation of new mutations
7. Long-term selection for a quantitative character in large replicate populations of Drosophila melanogaster. II. Lethals and visible mutants with large effects
8. Large genetic change at small fitness cost in large populations of Drosophila melanogaster selected for wind tunnel flight: Rethinking fitness surfaces
9. The genetics of species differences
10. QTL analysis in plants; where are we now?
11. Quantitative trait loci in Drosophila
12. Molecular and phenotypic variation in the achaete-scute region of Drosophila melanogaster
13. Both naturally occurring insertions of transposable elements and intermediate frequency polymorphisms at the achaete scute complex are associated with variation in bristle number in Drosophila melanogaster
14. The population genetics of Drosophila transposable elements
15. Linkage disequilibrium mapping of molecular polymorphisms at the scabrous locus associated with naturally occurring variation in bristle number in Drosophila melanogaster
16. Two sites in the Delta gene region contribute to naturally occurring variation in bristle number in Drosophila melanogaster
17. The detection of gametic disequilibrium between allozyme loci in natural populations of Drosophila
18. African and North American populations of Drosophila melanogaster are very different at the DNA level
19. Recombination and the frequency spectrum in Dresophila melanogaster and Drosophila simulans
20. Haplotype dimorphism in a SNP collection from Drosophila melanogaster
21. Molecular dissection of a major gene effect on a quantitative trait: The level of alcohol dehydrogenase expression in Drosophila melanogaster
22. Genetic variation affecting the expression of enzyme-coding genes in Drosophila: An evolutionary perspective
23. Searching for genetic determinants in the new millennium
24. Association study designs for complex diseases
25. How many diseases does it take to map a gene with SNPs?
26. Characterization of a yield quantitative trait locus on chromosome five of maize by fine mapping
27. Fine mapping of trypanosomiasis resistance loci in murine advanced intercross lines
28. A major effect QTL determined by multiple genes in epileptic EL mice
29. Fine mapping of a quantitative trait locus (QTL) from Lycopersicon hirsutum chromosome 1 affecting fruit characteristics and agronomic traits: Breaking linkage among QTL affecting different traits and dissection of heterosis for yield
30. Localization of two insulin-dependent diabetes (ldd) genes to the Idd 10 region on mouse chromosome 3
31. Fine mapping and characterization of linked quantitative trait loci involved in the transition of the maize apical meristem from vegetative to generative structures
32. Further characterization of the Odysseus locus of hybrid sterility in Drosophila: One gene is not enough
33. The evolution of apical dominance in maize
34. fw2.2: A quantitative trait locus key to the evolution of tomato fruit size
35. A recombination hotspot delimits a wild-species quantitative trait locus for tomato sugar content to 484 bp within an invertase gene
36. The limits of selection during maize domestication
37. Pleiotropic models of quantitative variation
38. Heritable genetic variation via mutation-selection balance: Leroh's ζ meets the abdominal bristle
39. The maintenance of genetic variability by mutation in a polygenic character with linked loci
40. Apparent stabilizing selection and the maintenance of neutral genetic variation
41. Deleterious mutations and the evolution of sex
42. Multivariate mutation-selection balance with constrained pleiotropic effects
43. Effects of pleiotropy on predictions concerning mutation-selection balance for polygenic traits
44. Quantitative genetic variability maintained by mutation/stabilising selection balance in finite populations
45. Effects of single P-element insertions on bristle number and viability in Drosophila melanogastar
46. Pleiotropic stabilising selection limits the number of polymorphic loci to at most the number of characters
47. Evolution in populations in approximate equilibrum
48. Genotype-environment interactions and the maintenance of polygenic variation
49. On models of quantitative genetic variation: A stabilizing selection-balance model
50. Genetic variation for morphological and allozyme variation in relation to population size in Clarka dudleyana, an endemic annual
51. Genetic variability of plant characters in the partial inbreeder Collinsia heterophylla (Scrophulariaceae)
52. Disruptive selection and the genetic basis of bill size polymorphism in the African finch Pyrenestes
53. Quantitative genetic variance maintained by fluctuating selection with overlapping generations: Variance components and covariances
54. Frequency- and density-dependent selection on a quantitative character
55. Evolution of genetic variability and the advantage of sex and recombination in changing environments
56. Sex and adaptation in a changing environment
57. High genetic variability under the balance between symmetric mutation and fluctuating stabilizing selection
58. Effect of selection against extreme deviants based on deviation or on homozygosis
59. Pleiotropic overdominance and the maintenance of genetic variation in polygenic characters
60. Adaptation at specific loci. III. Field behaviour and survivorship differences among Colias PGI genotypes are predictable from in vitro biochemistry
61. Excess polymorphism in the Adh region of Drosophila melanogaster
62. The population genetics of adaptation: The distribution of factors fixed during adaptive evolution
63. The distribution of the effects of genes affecting quantitative traits in livestock
64. The isolation of polygenic factors controlling bristle score in Drosophila melanogaster. II. Distribution of third chromosome bristle effects within chromosome sections
65. Adaptation and the cost of complexity
66. A yeast prion provides a mechanism for genetic variation and genetic diversity
67. Protein dispensability and rate of evolution
68. Functional analysis of the genes of yeast chromosome V by genetic foolprinting
69. Computational studies of gene regulatory networks: In numero molecular biology
70. An analysis of polygenes affecting wing shape on chromosome 3 in Drosophila melanogaster
71. Models of quantitative genetic variation of flux in metabolic pathways
72. The molecular basis of dominance
73. Metabolic models of selection response
74. High-resolution mapping of quantitative trait loci for sternopleural bristle number in Drosophila melanogaster
75. High resolution genetic mapping of genetic factors affecting abdominal abdomínal bristle number in Drosophila melanogaster
76. Gene effects on a quantitative trait: Two-locus epistatic effects measured at microsatellite markers and at estimated QTL
77. Less-than-additive epistatic interactions of quantitative trait loci in tomato
78. Epistatic and environmental interactions for quantitative trait loci involved in maize evolution
79. Deleterious mutations and the evolution of sexual reproduction
80. Evolution in vitro: Analysis of a lineage of ribozymes
81. Modification of developmental instability and fitness - Malathion resistance in the Australian sheep blowfly, Lucilia cuprina
82. Adaptation to the fitness costs of antibiotic resistance in Escherichia coli
83. Evolutionary developmental biology and the problem of variation
84. Phenotype-genotype relationships in monogenic disease: Lessons from the thalassaemias
85. Quantitative genetic variance associated with chromosomal markers in segregating populations
86. Detection of putative quantitative trait locus in line crosses under infinitesimal genetic models
87. Consequences of recombination rate variation on quantitative trait locus mapping studies. Simulations based on the Drosophila melanogaster genome
88. QTL analysis - Further uses of marker regression
89. Of genes and genomes and the origin of maize
90. Genetic analysis of the morphological differences between maize and teosinte
91. Teosinte glume architecture 1: A genetic locus controlling a key step in maize evolution
92. Teosinte branched 1 and the origin of maize: Evidence for epistasis and the evolution of dominance
93. The isolation of polygenic factors controlling bristle score in Drosophila melanogaster. I. Allocation of third chromosome sternopleural bristle effect to chromosome sections
94. Resolution of quantitative traits into Mendelian factors by using a complete linkage map of restriction fragment length polymorphisms
95. Experimental strategies for the genetic dissection of complex traits in animal models
96. The organization of polygenic activity within a chromosome in Drosophila. 1. Hair characters
97. The genome sequence of Drosophila melanogaster
98. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps
99. Location of polygenes
100. Long-term selection for a quantitative character in large replicate populations of Drosophila melanogaster. I. Response to selection
101. Long-term selection for a quantitative character in large replicate populations of Drosophila melanogaster. III. The nature of residual genetic variability
102. The geometry of adaptation