Biologic activity of mitochondrial metabolites on aging and age-related hearing loss

American Journal of Otology

Volumn 21, Issue 2, 2000, Pages 161-167

  Seidman, Michael D ^a   Khan, Mumtaz J ^a   Bai, Uma ^a   Shirwany, Najeeb ^a   Quirk, Wayne S ^b  

^a HENRY FORD HEALTH SYSTEM   (United States)

^b MINNESOTA STATE UNIVERSITY   (United States)

Author keywords

Acetyl l carnitine; Age related hearing loss; Aging; Mitochondrial function; Lipoic acid

Indexed keywords

LEVACECARNINE; MITOCHONDRIAL DNA; THIOCTIC ACID;

AGING; ANIMAL EXPERIMENT; ARTICLE; AUDITORY THRESHOLD; CONTROLLED STUDY; DNA DAMAGE; DRUG EFFECT; DRUG SCREENING; HEARING LOSS; MITOCHONDRIAL RESPIRATION; NONHUMAN; PRESBYACUSIS; PRIORITY JOURNAL; RAT;

EID: 0034056134     PISSN: 01929763     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0196-0709(00)80003-4     Document Type: Article

References (29)

1. Gates GA, Caspery DM, Clark W, et al. Presbyacusis. Otolaryngol Head Neck Surg 1986;100:266-71.
2. Kimura RS, Schuknecht HF. The ultra structure of the human stria vascularis. Acta Otolaryngologica 1970;69:415-27.
3. Harkins SW. Effects of age and interstimulus interval on the brain stem auditory evoked potential. Int J Neurosci 1981;15:107-18.
4. Rosenhall U, Pederson K, Dotevall M. Effects of presbycusis and other types of hearing loss on auditory brain stem responses. Scand Audiol 1986;15:179-85.
5. Hoeffding V, Feldman ML. Changes with age in the morphology of the cochlear nerve in rats: light microscopy. J Comp Neurol 1988;276:537-46.
6. Axelsson A. The cochlear blood vessels in guinea pigs of different ages. Acta Otolaryngol (Stockh) 1971;72:172-81.
7. Seidman MD, Khan MJ, Dolan D, Quirk WS. Age-related differences in cochlear microcirculation and auditory brain stem response. Arch Otolaryngol Head Neck Surg 1996;122:1221-6.
8. Hattori K, Tanaka M, Sugiyama S, et al. Age-dependent increase in deleted mitochondrial DNA in the human heart: possible contributory factor to presbycardia. Am Heart J 1991;121:1735-42.
9. Wallace DC. Mitochondrial genetics: a paradigm for aging and degenerative diseases? Science 1992;256:628-32.
10. Seidman MD, Bai U, Khan MJ, et al. Association of mitochondrial DNA deletions and cochlear pathology: a molecular biologic tool. Laryngoscope 1996;106:777-83.
11. Shigenaga MK, Hagen TM, Ames BN. Oxidative damage and mitochondrial decay in aging. Proc Natl Acad Sci USA 1994;91: 10771-8.
12. Sapolsky RM, Krey LC, McEwen BS. Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging. J Neurosci 1985;5:1222-7.
13. Imperato A, Ramacci TM, Angelucci L. Acetyl L-carnitine enhances acetylcholine release in the striatum and hippocampus of awake freely moving rats. Neurosci Lett 1989:107:251-5.
14. Ghirardi O, Milano S, Ramacci MT, Angelucci L. Effects of acetyl L-carnitine chronic treatment on discrimination models in aged rats. Physiol Behav 1988;44:769-73.
15. Caprioli A, Ghirardi O, Ramacci MT, Angelucci L. Age-dependent deficits in radial maze performance in the rat: effect of chronic treatment with acetyl L-carnitine. Prog Neuropsychopharmacol Biol Psychiatry 1990;14:359-69.
16. Bast A, Haenen GRMM. Interlay between lipoic acid and glutathione in the protection against microsomal lipid peroxidation. Biochem Biophysiol Acta 1988;963:558-61.
17. Suzuki YJ, Aggarwal B, Packer L. Alpha-lipoic acid is a potent inhibitor of NF-Kb activation in human T cells. Biochem Biophysiol Res Commun 1992;189:1709-15.
18. Kagan VE, Shvedova A, Serbinova E, et al. Dihydrolipoic acid: a universal antioxidant both in the membrane and in the aqueous phase. Biochem Pharmacol 1992;44:1637-49.
19. Devasagayam TP, Subramanian M, Pradhan DS, Sies H. Chem Biol Int 1993;86:79-92.
20. Gadaleta MN, Petruzalla V, Daddabbo L, et al. Mitochondrial DNA transcription and translation in aged rat: effect of acetyl-L-carnitine. Ann NY Acad Sci 1994;717:150-60.
21. Semsei I, Szeszek F, Nagy I. In-vivo studies of the age dependent decrease of the rates of total and mRNA synthesis in the brain cortex of rats. Arch Gerontol Geriatr 1982;1:29-42.
22. Richardson A, Butler JA, Rutherford MS, et al. Effects of age and dietary restrictions on the expression of alpha-2 μ-microglobulin. J Biol Chem 1987;262:605-13.
23. Bai U, Seidman MD, Hinojosa R, Quirk WS. Mitochondrial DNA deletions associated with aging and possibly presbyacusis: a human archival temporal bone study. Am J Otol 1997;18:1-5.
24. Paradies G, Ruggiero FM, Petrosillo G, Gadaleta MN, Quaglieriello E. Carnitine-acylcarnitine translocase activity in cardiac mitochondria from aged rats: the effect of acetyl-L-carnitine. Mech Aging Dev 1995;84:103-12.
25. Aureli T, Miccheli A, Ricciolini R, et al. Aging brain: effect of acetyl L-carnitine treatment on rat brain energy and phospholipid metabolism. A study by 31P and 1H NMR spectroscopy. Brain Res 1990;526:108-12.
26. Sebinova E, Khwaja S, Reznick AZ, Packer L. Thioctic acid protects against ischemia-reperfusion injury in the isolated perfused Langendorff heart. Free Rad Res Commun 1994;17:49-58.
27. Miyabayashi S, Hanamizu H, Endo H, et al. A new type of mitochondrial DNA deletion in patients with encephalomyopathy. J Inher Metab Dis 1991;14:805-12.
28. Ballinger SW, Shoffner JM, Hedaya EV, et al. Maternally transmitted diabetes and deafness associated with a 10.4 kb mitochondrial DNA deletion. Natl Genet 1992;1:3-7.
29. Maassen JA, Van Den Ouweland JM, 't Hart LM, Lemkes HH. Maternally inherited diabetes and deafness: a diabetic subtype associated with a mutation in mitochondrial DNA. Hormone Met Res 1997;29:50-55.