Possible confounding influence of strain, age and gender on cognitive performance in rats

Cognitive Brain Research

Volumn 3, Issue 3-4, 1996, Pages 251-267

  Andrews, J S ^a  

^a NV ORGANON   (Netherlands)

Author keywords

Aging; Memory; Rat; Sex difference; Strain difference

Indexed keywords

AGING; ANIMAL EXPERIMENT; ARTICLE; COGNITION; MEMORY; NONHUMAN; PERFORMANCE; PRIORITY JOURNAL; RAT; SEX DIFFERENCE; STRAIN DIFFERENCE;

EID: 0029977847     PISSN: 09266410     EISSN: None     Source Type: Journal    
DOI: 10.1016/0926-6410(96)00011-0     Document Type: Article

References (193)

1. Acri, J.B., Brown, K.J., Saah, M.I. and Grunberg, N.B., Strain and age differences in acoustic startle responses and effects of nicotine in rats, Pharmacol. Biochem. Behav., 50 (1995) 191-198.
2. Abel, E.L., Response to alarm substance in different rat strains, Physiol. Behav., 51 (1992) 345-347.
3. Al-Dahan, M.I.M. and Thomas, P.J., Contrasting effects of testicular and ovarian steroids upon muscarinic binding sites in the brain, Pharmacology, 34 (1987) 250-258.
4. Ambrosio, E., Goldberg, S.R. and Elmer, G.I., Behavior genetic investigation of the relationship between spontaneous locomotor activity and the acquisition of morphine self-administration behavior, Behav. Pharmacol., 6 (1995) 229-237.
5. Amit, Z. and Smith, B.R., Differential intake in Tryron maze-bright and Tryron maze-dull rats: implications for the validity of the animal model of selectively bred rats for high ethanol consumption, Psychopharmacology, 108 (1992) 136-140.
6. Andrews, J.S., Grützner, M. and Stephens, D.N., Effects of cholinergic and non-cholinergic drugs on visual discrimination and delayed visual discrimination performance in rats, Psychopharmacology, 106 (1992) 523-530.
7. Andrews, J.S. and Holtzman, S.G., Effects of d-amphetamine, morphine, naloxone and drug combinations on visual discrimination in rats, Psychopharmacology, 94 (1988) 172-177.
8. Andrews, J.S., Jansen, J.H.M., Linders, S. and Princen, A., The effects of disrupting the cholinergic system on short-term spatial memory in rats, Psychopharmacology, 115 (1994) 485-494.
9. Andrews, J.S., Jansen, J.H.M., Linders, S., Princen, A., and Broekkamp, C.L.E., Performance of four different rat strains in the autoshaping, two object discrimination and swim maze tasks of learning and memory, Physiol. Behav., 57 (1995) 785-790.
10. Archer, J., Sex differences in the emotional behavior of three strains of laboratory rats, Anim. Learn. Behav., 2 (1974) 43-48 (1974).
11. Archer, J., Rodent sex differences in emotional and related behavior, Behav. Biol., 4 (1975) 451-479.
12. Armstrong, D.M., Sheffield. R., Buzsaki, G., Chen, K.S., Hersh, L.B., Nearing, B. and Gage, F.H., Morphologic alterations of choline acetyltransferase-positive neurons in the basal forebrain of aged behaviorally characterized Fisher 344 rats, Neurobiol. Aging, 14 (1993) 457-470.
13. Aulakh, C.S., Hill, J.L. and Murphy, D.L., A comparison of feeding and locomotion responses to serotonin agonists in three rat strains, Pharmacol. Biochem. Behav., 31 (1989) 567-571.
14. Baker, M.A. (Ed.), Sex Differences in Human Performance, Wiley, New York, NY, 1987.
15. Barnes, C.A., Eppich, C. and Rao, G., Selective improvement of aged rat short-term spatial memory by 3,4-diaminopyridine, Neurobiol. Aging, 10 (1989) 337-341.
16. Barnes, C.A., Nadel, L. and Honig, W.K., Spatial memory deficit in senescent rats, Can. J. Psychol., 34 (1980) 29-39.
17. Bartus, R.T., Dean, III, R.L., Beer, B. and Lippa, A.S., The cholinergic function of geriatric memory dysfunction, Science, 217 (1982) 408-417.
18. Beatty, W.W., Effects of gonadectomy on sex differences in DRL behavior, Physiol. Behav., 10 (1973) 177-178.
19. Beatty, W.W., Bierley, R.A. and Boyd, J.G., Preservation of accurate spatial memory in aged rats, Neurobiol. Aging, 6 (1986) 219-225.
20. Beatty, W.W. and Holzer, G.A., Sex differences in sterotyped behavior in the rat, Pharmacol. Biochem. Behav., 9 (1978) 777-783.
21. Bell, D.D. and Zucker, I., Sex/differences in bodyweight and eating: organization and activation by gonadal hormones in the rat, Physiol. Behav., 7 (1971) 27-34.
22. Bender, K., Balogh, P., Bertrand, M.F. and den Bieman, M., Genetic characterization of inbred strains of the rat (Rattus norvegicus), J. Exp. Anim. Sci., 36 (1994) 151-165.
23. Bender, K., Seibert, R.T., Wienker, T.F. and Kren, V., Biochemical genetics of methylglyoxal dehydrogenases in the laboratory rat (Rattus norvegicus), Biochem. Genet., 32 (1994) 147-154.
24. Bignami, G., Selection for high rates and low rates of avoidance conditioning in the rat, Anim. Behav., 13 (1965) 221-227.
25. Blanchard, R.J., Yudko, E.B., Rodgers, R.J. and Blanchard, D.C., Defense system psychopharmacology: an ethological approach to the pharmacology of fear and anxiety, Behav. Brain Res., 58 (1993) 155-165.
26. Blokland, A. and Raaijmakers, W., Age-related changes in correlation between behavioural and biochemical parameters in Lewis rats, Behav. Neural Biol., 60 (1993) 52-61.
27. Boice, R., Behavioral comparability of wild and domesticated rats, Behav. Genet., 11 (1981) 545-553.
28. Broadhurst, P.L., The Maudsley reactive and nonreactive strains of rats: a survey, Behav. Genet., 5 (1975) 299-319.
29. Bucci, D.J., Chiba, A.A. and Gallagher, M., Spatial learning in male and female Long-Evans rats, Behav. Neurosci., 109 (1995) 180-183.
30. Bushnell, P.J., Modelling working and reference memory in rats: effects of scopolamine on delayed matching-to-position, Behav. Pharmacol., 1 (1990) 419-427.
31. Bushnell, P.J., Levin, E.D. and Overstreet, D.H., Spatial working memory in rats bred for autonomic sensitivity to cholinergic stimulation: acquisition, accuracy, speed, and effects of cholinergic drugs, Neurobiol. Learn., 63 (1995) 116-132.
32. Buxton, A., Callan, O.A., Blatt, E.J., Wong, E.H.F. and Fontana, D.J., Cholinergic agents and delay-dependent performance in the rat, Pharmacol. Biochem. Behav., 49 (1994) 1067-1073.
33. Campbell, A. and Baldessarini, R.J., Effects of maturation and aging on behavioral responses to haloperidol in the rat, Psychopharmacology, 73 (1981) 219-222.
34. Campbell, A., Baldessarini, R.J., Stoll, A., Teicher, M.H. and Maynard, P., Effect of age on behavioral responses and tissue levels of apomorphine in the rat, Neuropharmacology, 23 (1984) 725-730.
35. Carli, M. and Samanin, R., Serotonin 2 receptor agonists and serotonergic anorectic drugs affect rats' performance differently in a five-choice serial reaction time task, Psychopharmacology, 106 (1992) 228-234.
36. Ciurgea, Griendl, G. and Preat, S., Experimental behavioral pharmacology of gerontopsychopharmacological agents. In F. Hoffmeister and G. Stille (Eds.), Handbook of Experimental Pharmacology 55 (II), Springer, Berlin, Germany, 1981, pp. 461-492.
37. Claasen, V., Neglected Factors in Pharmacology and Neuroscience Research, Elsevier, Amsterdam, The Netherlands, 1994.
38. Cole, B.J., Jones, G.H. and Turner, J.D., 5-HT-1A receptor agonists improve performance of normal and scopolamine-impaired rats in an operant delayed matching to position task, Psychopharmacology, 116 (1994) 135-142.
39. Cole, B.J. and Robbins, T.W., Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi on performance of a 5-choice serial reaction time task in rats: implications for theories of selective attention and arousal, Behav. Brain Res., (1989) 165-179.
40. Cooper, R.M. and Zubeck, J.P., Effects of enriched and restricted early environments on the learning ability of bright and dull rats, Can. J. Psychol., 12 (1958) 159-164.
41. Corey, S.M., Sex differences in maze learning by white rats, J. Comp. Psychol., 10 (1930) 333-338.
42. Creel, D.J., Dustman, R.E. and Beck, E.C., Differences in visually evoked responses in albino versus hooded rats, Exp. Neurol., (1970) 298-309.
43. Creel, D.J. and Giolli, R.A., Retingeniculate projections in abino and ocularly hypopigmented rats, J. Comp. Neurol., 166 (1976) 445-456.
44. Davis, H., Porter, J.W., Burton, J. and Levine, S., Sex and strain differences in leverpress shock escape behavior, Physiol. Behav., 4 (1976) 351-356.
45. Dawkins, K., Gender differences in psychiatry: epidemiology and drug response, CNS Drugs, 3 (1995) 393-407.
46. Dawson, G.W., Bentley, G., Draper, F., Rycroft, W., Iversen, S.D. and Pagella, P.G., The behavioral effects of heptyl physostigmine, a new cholinesterase inhibitor, in tests of long-term and working memory in rodents, Pharmacol. Biochem. Behav., 39 (1991) 865-871.
47. Dawson, G.R., Bayley P., Channell, S. and Iversen, S.D., A comparison of the effects of the novel muscarinic receptor agonists L-689,660 and AF102B in tests of reference and working memory, Psychopharmacology, 113 (1994) 361-368.
48. Deacon, R.M.J., Pharmacological studies of a rat spatial delayed nonmatch-to-sample task as an animal model of dementia, Drug Den. Res., 24 (1991) 67-79.
49. Diana, G., Domenici, M.R., Loizzo, A., Scotti de Carolis, A. and Sagratella, S., Age and strain differences in rat place learning and hippocampal dentate gyrus frequency-potentiation, Neurosci. Lett., 171 (1994) 113-116.
50. Didriksen, M., Effects of antipsychotics on cognitive behaviour in rats using the delayed non-match to position paradigm, Eur. J. Pharmacol., 281 (1995) 241-250.
51. Didriksen, M. and Christensen, A.V., Differences in performance in three strains of rats in a 5-choice serial reaction time task, Pharmacol. Toxicol., 72 (1993) 66-68.
52. Dunbar, G.L., Rylett, R.J., Schmidt, B.M., Sinclair, R.C. and Williams, L.R., Hippocampal choline acetyltransferase activity correlates with spatial learning in aged rats, Brain Res., 604 (1993) 266-272.
53. Dunnett, S.B., Comparative effects of cholinergic drugs lesions of nucleus basalis or fimbria-fornix on delayed matching in rats, Psychopharmacology, 87 (1985) 357-363.
54. Dunnett, S.B., Badman, F., Rogers, D.C., Evenden, J.L., and Iversen, S.D., Cholinergic grafts in the neocortex or hippocampus of aged rats: reduction of delay-dependent deficits in the delayed non-matching to position task, Exp. Neurol., 102 (1988) 57-64.
55. Dunnett, S.B., Evenden, J.L. and Iversen, S.D., Delay-dependent short-term memory deficits in aged rats, Psychopharmacology, 96 (1988) 174-180.
56. Dyer, R.S. and Swartzwelder, H.S., Sex and strain differences in the visual evoked potentials of albino and Hooded rats, Pharmacol. Biochem. Behav., 9 (1978) 301-306.
57. Eldridge, J.C., Fleenor-Heyser, D.G., Extrom, P.C., Wetzel, L.T., Breckenbridge, C.B., Gillis, J.H., Luempert L.G. and Stevens, J.T., Short-term effects of chlorotriazines on estrus in female Sprague-Dawley and Fischer 344 rats, J. Toxicol. Environ. Health, 43 (1994) 155-167.
58. Escorihuela, R.M., Tobena, A. and Fernandez-Teruel, A., Environmental enrichment and postnatal handling prevent spatial learning deficits in aged hypoemotional (Roman high-avoidance) and hyperemotional (Roman low-avoidance) rats, Learn. Mem., 2 (1995) 40-48.
59. Evenden, J.L. and Marston, H.M., Jones, G.H., Giardini, V., Lenard, L., Everitt, B.J. and Robbins, T.W., Effects of excitoxic lesions of the substantia innominata, ventral and dorsal globus pallidus on visual discrimination acquisition, performance and reversal in the rat, Behav. Brain Res., 32 (1989) 129-149.
60. Ferris, D.C., Kume-Kick, J., Russo-Menna, I. and Rice, M.E., Gender differences in cerebral ascorbate levels and ascorbate loss in ischemia, NeuroReport, 6 (1995) 1485-1489.
61. Fischer, W., Gage, F.H. and Bjorklund, A., Degenerative changes in forebrain cholinergic nuclei correlate with cognitive impairments in aged rats, Eur. J. Neurosci., 1 (1989) 34-45.
62. Fishkin, R.J., Ince, E.S., Carlezon, W.A. and Dunn, R.W., D-Cycloserine attenuates scopolamine-induced learning and memory deficits in rats, Behav. Neural Biol., 59 (1993) 150-157.
63. Freeman, J.J., Macri, J.R., Choi, R.L. and Jenden, D.J., Studies on the behavioral and biochemical effects of hemicholinium in vivo, J. Pharmacol. Exp. Ther., 210 (1979) 91-97.
64. Fregley, M.J., Paulding, W. and Rowland, N.E., Comparison of the dipsogenic responsiveness of Long Evans and Sprague-Dawley rats, Physiol. Behav., 47 (1990) 1187-1192.
65. Gage, F.H., Chen, K.S., Buzsaki, G. and Armstrong, D., Experimental approaches to age-related cognitive impairments, Neurobiol. Aging, 9 (1989) 645-655 (1989).
66. Gage, F.H., Dunnett, S.B. and Bjorklund, A., Spatial learning and motor deficits in aged rats, Neurobiol. Aging, 5 (1984) 43-48.
67. Gage, F.H., Dunnett, S.B. and Bjorkland, A., Age-related impairments in spatial memory are independent of those in motor skills, Neurobiol. Aging, 10 (1989) 347-352.
68. Gallagher, M., Burwell, R. and Burchinall, M., Severity of spatial learning impairment in aging: development of a learning index for performance in the Morris water maze, Behav. Neurosci., 107 (1993) 618-626.
69. George, F.R. and Goldberg, S.R., Genetic approaches to the analysis of addiction processes, TIPS, 10 (1989) 78-83.
70. Giogi, O., De Monti, G., Perceddu, M.L., Mele, S., Calderini, G., Toffana, G. and Biggio, G., Developmental and age-related changes in D1 dopamine receptors and dopamine content in the rat striatum, Dev. Brain Res., 35 (1987) 283-290.
71. Glendinning, J.I. and Smith, J.C., Consistency of meal patterns in laboratory rats, Physiol. Behav., 56 (1994) 7-16.
72. Glowa, J.R. and Hansen, C.T., Differences in response to an acoustic startle stimulus among fourty-six rat strains, Behav. Genet., 24 (1994) 79-84.
73. Grauer, E. and Kapon, Y., Wistar-Kyoto rats in the Morris water maze: impaired working memory and hyperreactivity to stress, Behav. Brain Res., 59 (1993) 147-151.
74. Greenhouse, D.D., Festing, M.F.W., Hasan, S. and Cohen, A.L., Inbred strains of rats. In H.J. Hedrich (Ed.), Genetic Monitoring of Inbred Strains of Rats, Gustav Fischer, Stuttgart, Germany, 1990.
75. Guillamon, A., Valencia, A., Cales, J.M. and Segovia, S., Effects of early postnatal steroids on the conditional discrimination reversal learning in the rat, Physiol. Behav., 38 (1986) 845-849.
76. Hagan, J.J., Jansen, J.H.M. and Broekkamp, C.L.E., Hemicholinium-3 impairs spatial learning and the deficit is reversed by cholinomimetics, Psychopharmacology, 98 (1989) 347-356.
77. Hamm, R.J. and Knisely, J.S., Ontogeny of an endogenous nonopoid and hormonally mediated analgesic system, Dev. Psychobiol., 20 (1987) 539-548.
78. Heinsbroek, R.P.W., van Haaren, F., Zantvoord, F. and van de Poll, N.E., Sex differences in response rates during random ratio acquisition: effects of gonadectomy, Physiol. Behav., 39 (1987) 269-272.
79. Hendley, E.D., Wessel, D.J., Atwater, D.G., Gellis, J., Whitehorn, D. and Low, W.C., Age, sex and strain differences in activity in SHR and WKY rats, Physiol. Behav., 34 (1985) 379-383.
80. Higashida, A. and Ogawa, N., Differences in the acquisition process and the effect of scopolamine on radial maze performance in three strains of rats, Pharmacol. Biochem. Behav., 27 (1987) 483-489.
81. Hirate, K., Kuriba, H. and Tadokoro, S., Breeder differences within Wistar strain rats in acquisition of discrete shuttle avoidance response and in sensitivity to chlorpromazine, Jpn. J. Pharmacol., 47 (1988) 209-216.
82. Hoffman, H.J., Survival distributions for selected laboratory rat strains and stocks. In D.C. Gibson et al. (Eds.), Development of the Rodent as a Model System of Aging, US Department of Health, Education and Welfare, Washington, DC, 1979.
83. Howard, J.L. and Pollard, G.T., Effects of imipramine, buproprion, chlorpromazine, and cloazapine on differential-reinforcement-of-low-rate (DRL) > 72-s and > 36-s schedules in rat, Drug Dev. Res., 4 (1984) 607-616.
84. Hulihan-Giblin, B.A., Park, Y.D., Goldman, D. and Aulakh, C.S., Analysis of the 5-HT1c receptor and serotonin uptake site in Fawn Hooded rat brain, Eur. J. Pharmacol., 239 (1993) 99-102.
85. Humpel, C., Neudorfer, C, Philipp, W., Steiner, H.J., Haring, C., Schmid, K.W., Schwitzer, J. and Saria, A., Effects of bright artificial light on monoamines and neuropeptides in eight different brain regions compared in a pigmented and nonpigmented rat strain, J. Neurosci. Res., 32 (1992) 605-612.
86. Hunter, A.J. and Roberts, F.F., The effect of pirenzepine on spatial learning in the Morris water maze, Pharmacol. Biochem. Behav., 30 (1988) 519-523.
87. Imhof, J.T., Coelho, Z.M., Schmitt, M.L., Morato, G.S. and Carobrez, A.P., Influence of gender and age on performance of rats in the elevated plus maze apparatus, Behav. Brain Res., 56 177-180.
88. Jackson, A., Koek, W. and Colpaert, F.C., Can the DRL 72s schedule selectively reveal antidepressant drug activity, Psychopharmacology, 117 (1995) 154-161.
89. Jewell, A., Wedlund, P. and Dwoskin, L., Strain differences in rat brain and liver sigma binding: lack of cytochrome P450-2D1 involvement, Eur. J. Pharmacol., 243 (1993) 249-254.
90. Kirkby, D.L., Jones, D.N.C. and Higgins, G.A., Hemicholinium-3 and cognition, J. Psychopharmacol., 52 (1994) pA13.
91. Lindner, M.D. and Gribkoff, V.K., Relationship between performance in the Morris water task, visual acuity, and thermoregulatory function in aged F-344 rats, Behav. Brain Res., 45 (1991) 45-55.
92. Lindner, M.D. and Schallert, T., Aging and atropine effects on spatial navigation in the Morris water task, Behav. Neurosci., 102 (1988) 621-634.
93. Lindsey, J.R., Historical foundations in the laboratory rat. In H.J. Baker et al. (Eds.), The Laboratory Rat, Academic Press, New York, NY, 1979, pp. 1-36.
94. Livezey, G.T., Miller, J.M. and Vogel, W.H., Plasma norepinephrine, epinephrine and corticosterone stress responses to restraint in individual male and female rats, and their correlations, Neurosci. Lett., 62 (1985) 51-56.
95. Lockard, R.B., The albino rat: a defensible choice or a bad habit? Am. Psychol., 23 (1968) 734-742.
96. Lorenzini, C.A., Bucherelli, C., Falchini, S., Giachetti, A. and Tassoni, G., The rat's left-right preference during free exploration of a multiple Y-maze, Physiol. Behav., 48 (1990) 175-177.
97. Lorenzini, C.A., Bucherelli. C., Giachetti, A. and Tassoni, G., The behavior of the homozygous and heterozygous subtypes of rats which are genetically-selected for diabetes insipidus: a comparison with Long Evans and Wistar stocks, Experientia, 47 (1991) 1019-1026.
98. Loy, R. and Sheldon, R.A., Sexually dimorphic development of cholinergic enzymes in the rat septohippocampal system, Dev. Brain Res., 34 (1987) 156-160.
99. Luitjlaar, E.L.J.M., van der Staay, F.J. and Kerbusch, J.M.L., Spatial memory in rats: a cross validation study, Q. J. Exp. Psychol., 418 (1989) 287-306.
100. Mandel, R.J., Gage, F.H. and Thal, L.J., Enhanced detection of nucleus basalis magnocellularis lesion-induced spatial learning deficit in rats by modification of training regimen, Behav. Brain Res., 31 (1989) 221-229.
101. Markowitz, H. and Becker, C.J., Superiority of 'maze dull' animals on visual tasks in an automated maze, Psychonom. Sci., 17 (1965) 257-258.
102. Markowska, A.L., Long, J.M., Johnson, C.T. and Olton, D.S., Variable-interval probe test as a tool for repeated measurements of spatial memory in the water maze, Behav. Neurosci., 107 (1993) 627-632.
103. Masaro, E.J., Mortality and growth characteristics of rat strains commonly used in aging research, Exp. Aging Res., 6 (1980) 219-232.
104. Mayo, W., Kharouby, M., Le Moal, M. and Simon, H., Memory disturbances following ibotenic acid injections in the nucleus basalis magnocellularis of the rat, Brain Res., 455 (1988) 213-222.
105. Mazurkiewicz, M., Sirvio, J. and Riekkinen, P., Effects of single and repeated administration of vigabratin on the performance of rats in a 5-choice serial reaction time task, Epilepsy Res., 13 (1992) 231-237.
106. McLamb, R.L., Williams, L.R., Nanry, K.P., Wilson, W.A. and Tilson, H.A., MK-801 impedes the acquisition of a spatial memory task in rats, Pharmacol. Biochem. Behav., 37 (1990) 41-45.
107. McNamara, R.K. and Skelton, R.W., Assessment of a cholinergic contribution to chlordiazeoxide-induced deficits of place learning in the Morris water maze, Pharmacol. Biochem. Behav., 41 (1992) 529-538.
108. Meaney, M.J., Aitken, D.H., Bhatnagar, S. and Sapolsky, R.M., Postnatal handling attenuates certain neuroendocrine, anatomical, and cognitive dysfunctions associated with aging in female rats, Neurobiol. Aging, 12 (1991) 31-38.
109. Means, L.W., Alexander, S.R. and O'Neal, M.F., Those cheating rats: male and female rats use odor trails in a water-escape 'working memory' task, Behav. Neural Biol., 58 (1992) 144-151.
110. Minabe, Y., Emori, K. and Ashby, C.R., Significant differences in the activity of midbrain dopamine neurons between male Fischer 344 (F344) and Lewis rats: an in vivo electrophysiological study, Life Sci., 56 (1995) 261-267.
111. Muir, J.L., Dunnett, S.B., Robbins, T.W. and Everitt, B.J., Attentional functions of the forebrain cholinergic systems: effects of intraventricular hemicholinium, physostigmine, basal forebrain lesions and intracortical grafts on a multiple choice serial reaction time task, Exp. Brain Res., 89 (1992) 611-622.
112. Murray, T.K., Cross, A.J. and Green, A.R., Reversal by tetrahydroaminoacridine of scopolamine-induced memory and performance deficits in rats, Psychopharmacology, 105 (1991) 134-136.
113. Myslivek, J. and Hassmannova, J., Early inhibitory learning in the rat. I. Learning and memory development. Dev. Psychobiol., 23 (1990) 119-128.
114. Nanry, K.P., Mundy, W.R. and Tilson, H.A., Colchicine-induced alterations of reference memory in rats, role of spatial versus non-spatial task components, Behav. Brain Res., 35 (1989) 45-53.
115. Neave, N. Sahgal, A. and Aggleton, J.P., Lack of effect of dorsomedial thalamic lesions on automated tests of spatial memory in the rat, Behav. Brain Res., 55 (1993) 39-49.
116. Nilsson, O.G. and Gage, F.H., Anticholinergic sensitivity in the aging rat septohippocampal system as assessed in a spatial memory task, Neurobiol. Aging, 14 (1993) 487-497.
117. Nilsson, O.G., Leanza, G., Rosenblad, C., Lappi, D.A., Wiley, R.G. and Bjorklund, A., Spatial learning impairments in rats with selective immunolesion of the forebrain cholinergic system, NeuroReport, 3 (1992) 1005-1008.
118. Oliff, H.S., Weber, E., Eilon, G. and Marek, P., The role of strain/vendor differences on the outcome of focal ischemia induced by intraluminal middle cerebral artery occlusion in the rat, Brain Res., 675 (1995) 20-26.
119. Onaivi, E.S., Maguire, P.A., Tsai N.F., Davies, M.F. and Loew, G.H., Comparison of behavioral and central BDZ binding profile in three rat lines, Pharmacol. Biochem. Behav., 43 (1992) 825-831.
120. Overstreet, D.H., The Flinders sensitive line rats: a genetic animal model of depression, Neurosci. Biobehav. Rev., 17 (1993) 51-68.
121. Page, K.J., Everitt, B.J., Robbins, T.W., Marston, H.M. and Wilkinson, L.S., Dissociable effects on spatial maze and passive avoidance acquisition and retention following AMPA- and ibotenic acid-induced excitotoxic lesions of the basal forebrain in rats, differential dependence on cholinergic neuronal loss, Neuroscience, 43 (1991) 457-472.
122. Pare, W.P., Open field, Learned helplessness, conditioned defensive burying, and forced-swim tests in WKY rats, Physiol. Behav., 55 (1994) 433-439.
123. Pare, W.P., Hyponeophagia in Wistar Kyoto (WKY) rats, Physiol. Behav., 55 (1994) 975-978.
124. Paul, I.A., Duncan, G.E., Kuhn, C., Mueller, R.A., Hong, J.S. and Breese, G.R., Neural adaptation in imipramine treated rats processed in forced swim test: assessment of time course, handling, rat strain and amine uptake, J. Pharmacol. Exp. Ther., 252 (1990) 997-1005.
125. Paylor, R. and Rudy, J.W., Cholinergic receptor blockade can impair rat's performance on both the place learning and cued versions of the Morris water task: the role of age and pool brightness, Behav. Brain Res., 36 (1990) 79-90.
126. Pearson, J.L. and Ferguson, R., Gender differences in patterns of spatial ability, environmental cognition, and math and English achievement in late adolescence, Adolescence, 24 (1989) 421-431.
127. Pellymounter, M.A., Smith, M.Y. and Gallagher, M., Spatial learning impairments in aged rats trained with a salient configuration of stimuli, Psychobiology, 13 (1987) 284-354.
128. Pitsikas, N., Brambilla, A. and Borsini, F., Effect of DAU 6215, a novel 5-HT3 receptor antagonist, on scopolamine-induced amnesia in the rat in a spatial learning task, Pharmacol. Biochem. Behav., 47 (1994) 95-99.
129. Pollard, G.T. and Howard, J.L., Similar effects of antidepressant and non-antidepressant drugs on behavior under an interresponse-time > 72-s schedule, Psychopharmacology, 89 (1986) 253-258.
130. Porsolt, R.D., Bertin, A. and Jalfre, M., 'Behavioural despair' in rats and mice: strain differences and the effects of imipramine, Em. J. Pharmacol., 51 (1978) 291-294.
131. Potier, B., Lamour, Y. and Dutar, P., Cholinergic and non-cholinergic synaptic mechanisms in the aged rat hippocampus, Ann. N.Y. Acad. Sci., 695P (1993) 236-240.
132. Price, E.O., Behavioral aspects of animal domestication, Q. Rev. Biol., 39 (1984) 1-30.
133. Ramirez, I., Strain differences in dietery hyperphagia: interactions with age and experience, Physiol Behav., 49 (1991) 89-92.
134. Rapp, P.R., Rosenberg, R.A. and Gallagher, M., An evaluation of spatial information processing in aged rats, Behav. Neurosci., 101 (1987) 3-12.
135. Rauch, T.M., Welch, D.I. and Gallego, L., Hypothermia impairs performance in the Morris water maze, Physiol. Behav., 45 (1989) 315-320.
136. Reading, P.J. and Dunnett, S.B., Response disinhibition on a delayed matching to position task induced by amphetamine, nicotine and age, Psychopharmacology, 104 (1991) 137-139.
137. Riekkinen, P., Jr., Sirvio, J., Ekonsalo, T. and Riekkinen, P., Effects of noradrenergic DSP4 lesion on the effectiveness of pilocarpine in reversing scopolamine-induced amnesia, Brain Res. Bull., 28 (1992) 919-922.
138. Rogers, L.J., Bolden, S.W., Patrech, A.S. and Ehrlich, D., Visual dysfunction in the sponateneously hypertensive rat, Physiol. Behav., 54 (1993) 903-907.
139. Roof, R.L., Neonatal exogenous testosterone modifies sex difference in radial arm and Morris water maze performance in prepubescent and adult rats, Behav. Brain Res., 53 (1993) 1-10.
140. Roof, R.L. and Havens, M.D., Testosterone improves maze performance and induces development of a male hippocampus in females, Brain Res., 572 (1992) 310-313.
141. Roof, R.L., Zhang, Q., Glasier, MM. and Stein, D.G., Gender-specific impairment on Morris water maze task after entorhinal cortex lesion, Behav. Brain Res., 57 (1993) 47-51.
142. Russell, V., de Villers, A., Sagvolden, T., Lamm, M. and Taljaard, J., Altered dopaminegic function in the prefrontal cortex, nucleus accumbens and caudate-putamen of an animal model of attention-deficit hyperactivity disorder - the spontaneously hypertensive rat, Brain Res., 676 (1995) 343-351.
143. Ryan, C.N. and Lindberg, N., The effects of imipramine in different rats strains on the differential reinforcement of low rates test, J. Psychopharmacol., 5 Suppl. 1 (1994) 85.
144. Saavedra, M.A., Abarca, N., Arancibia, P. and Salinas, V., Sex differences in aversive and appetitive conditioning in two strains of rats, Physiol. Behav., 47 (1990) 107-112.
145. Sagvolden, T., Pettersen, M.B. and Larsen, M.C., Sponateously hypertensive rats (SHR) as a putative animal model of childhood hyperkinesis: SHR behavior compared to four other rat strains, Physiol. Behav., 54 (1993) 1047-1055.
146. Sahgal, A., Vasopressin retards the acquisition of positively rewarded lever pressing in homozygous Brattleboro rats, Reg. Pept., 5 (1983) 317-326.
147. Sahgal, A., A critique of the vasopressin-memory hypothesis, Psychopharmacology, 83 (1984) 215-228.
148. Sahgal, A., Keith, A.B. and Lloyd, S., Effects of nicotine, oxotremorine and 9-amino 1,2,3,4-tetrahydroacridine (tacrine) on matching and non-matching to position in rats: no evidence for mnemonic enhancement, J. Psychopharmacol., 4 (1990) 210-218.
149. Sahgal, A., Keith, A.B., Lloyd, S., Kerwin, J.M., Perry, E.K. and Edwardson, J.A., Memory following cholinergic (NMBM) and noradrenergic (DNAB) lesions made singly or in combination: potentiation of disruption by scopolamine, Pharmacol. Biochem. Behav., 37 (1990) 597-605.
150. Savageau, M.M. and Beatty, W.W., Gonadectomy and sex differences to amphetamine and apomorphine of rats, Pharmacol. Biochem. Behav., 14 (1981) 17-21.
151. Seiden, L.S., Dahms, J.L. and Shaughnessy, R.A., Behavioral screen for antidepressants: the effects of drugs and electroconvulsive shock on performance under a differential-reinforcement-of-low-rate schedule, Psychopharmacology, 86 (1985) 55-60.
152. Shanks, N. and Aisman, H., Strain-specific effects of antidepressants on escape deficits induced by inescapable shock, Psychopharmacology, 99 (1989) 122-128.
153. Shimokawa, I., Higami, Y., Hubbard, G.B., McMahan, C.A., Masaro, E.J. and Yu, B.P., Doet and the suitability of the male Fischer 344 rat as a model for aging research, J. Gerontol., 48 (1993) B27-B32.
154. Shephard, J.K., Rodgers, R.J., Blanchard, R.J., Magee, L.K. and Blanchard, D.C., Ondansetron, gender and antipredator defensive behaviour, J. Psychopharmacol., 7 (1993) 72-81.
155. Sirvio, J., Riekkenin, P., Jr., Valjakka, A., Jolkkonen, J. and Riekkinen, P.J., The effects of noradrenergic neurotoxin, DSP-4, on the performance of young and aged rats in spatial navigation task, Brain Res., 563 (1991) 297-302.
156. Sisson, D.F., Siegel, J. and Westenberg, I.S., Are the differential effects of chloral hydrate on Hooded rats vs. albino rats due to pigmentation or strain differences? Pharmacol. Biochem. Behav., 39 (1991) 665-670.
157. Slob, A.K. and van der Werff ten Bosch, J.J., Sex differences in body growth in the rat, Physiol Behav., 14 (1975) 353-361.
158. Smale, G., Bendele, A. and Horton, W.E., Comparison of age-associated degeneration of articular cartilage in Wistar and Fischer 344 rats, Lab. Anim. Sci., 45 (1995) 191-194.
159. Spangler, E.L., Waggie, K.S., Hengemihle, J., Roberts, D., Hess, B. and Ingram, D.K., Behavioral assessment of aging in male Fischer 344 and Brown Norway rat strains and their F1 hybrid, Neurobiol. Aging, 15 (1994) 319-328.
160. Steckler, T., Andrews, J.S., Marten, P. and Turner, J.D., Effects of NBM lesions with two neurotoxins on spatial memory and autoshaping, Pharmacol. Biochem. Behav., 44 (1993) 877-889.
161. Steckler, T., Keith, A.B., Wiley, R.G. and Sahgal, A., Cholinergic lesions by 192 IgG-saporin and short-term recognition memory: role of the septohippocampal projection, Neuroscience, 66 (1995) 101-114.
162. Steenbergen, H.L., Heinsbroek, R.P.W., van Hest, A. and van de Poll, N.E., Sex dependent effects of inescapable shock administration on shuttlebox-escape performance and elevated plus-maze behavior, Physiol. Behav., 48 (1990) 571-576.
163. Stewart, C.A. and Morris, R.G.M., The watermaze. In A. Sahgal (Ed.), Behavioural Neuroscience: A Practical Approach, Volume I, IRL Press, Oxford, UK, 1993, pp. 106-122.
164. Stewart, J., Mitchell, J. and Kalant, N., The effects of life-long food restriction on spatial memory in young and aged Fischer 344 rats measured in the eight-arm radial and Morris water mazes, Neurobiol. Aging, 10 (1989) 669-675.
165. Sugimoto, T., Fukuda, Y. and Wakakuwa K., Quantitative analysis of a cross-sectioned area of the optic nerve, Exp. Brain Res., 54 (1984) 266-274.
166. Tamaya, K. and Shisa, H., Development of pigmented scales on rat skin: relation to age, sex, strain, and hormonal effect, Lab. Anim. Sci., 44 (1994) 240-244.
167. Tinius, T., Beckwith, B.E. and Oltmanns, D., Arginine vasopressin facilitates reversal learning in albino, but not hooded rats, Peptides, 10 (1989) 237-239.
168. Valtin, H. and Schroeder, H.A., Familial hypothermic diabetes insipidus in rats (Brattleboro strain), Am. J. Physiol., 206 (1964) 425-430.
169. van den Buuse, M., Circadian rhythms of blood pressure, heart rate, and locomotor activity in spontaneously hypertensive rats as measured with radio-telemetry, Physiol. Behav., 55 (1994) 783-787.
170. van der Staay, F.J. and Blokland, A., Behavioral differences between outbred Wistar, inbred Fischer 344, Brown Norway, and hybrid Fischer 344 * Brown Norway rats, Physiol. Behav. in press.
171. van der Staay, F.J., Blokland, A. and Raaijmakers, W., Different timecourse for age-related changes of behaviour in a complex spatial con-field discrimination task in Lewis rats, Psychobiology, 18 (1990) 305-311.
172. van der Staay, F.J. and de Jonge, M., Effects of age on water escape behavior and on repeated acquisition in rats, Behav. Neural Biol., 60, 33-41 (1993).
173. van der Staay, F.W., Kerbusch, S. and Raaijmakers, W.G.M., Genetic correlations in validating emotionality, Behav. Genet., 20 (1990) 51-62.
174. van Haaren, F. and van Hest, A., The effects of scopolamine and methylscopolamine on visual and auditory discriminations in male and female Wistar rats, Pharmacol. Biochem. Behav., 32 (1989) 707-710.
175. van Haaren, F., van Hest, A. and van Hattum, T., Scopolamine and methylscopolamine differentially affect fixed-consecutive-number performance of male and female Wistar rats, Pharmacol. Biochem. Behav., 33 (1989) 361-365.
176. van Haaren, F., van Hest, A. and Heinsbroek, R.P.W., Behavioral differences between male and female rats: effects of gonadal hormones on learning and memory, Neurosci. Biobehav. Rev., 14 (1990) 23-33.
177. van Haaren, F., Wouters, M. and van de Poll, N.E., Absence of behavioral differences between male and female rats in different radial-maze procedures, Physiol. Behav., 39 (1987) 409-412.
178. van Haaren, F., van Hest, A. and van de Poll, N.E., Acquisition and reversal of a discriminated autoshaped response in male and female rats: effects of long or short response and fixed or variable interval intertrial interval durations, Learn. Motiv., 18 (1987) 220-223.
179. van Haaren, F., van Hest, A. and van de Poll, N.E., Perseverative responding in male and female Wistar rats: effects of gonadal hormones, Horm. Behav., 23 (1989) 57-67.
180. van Hest, A. and van Haaren, F., The effects of gonadectomy and chronic testosterone suppletion on the autoshaped response of male and female Wistar rats, Bull. Psychon. Soc., 27 (1989) 45-48.
181. van Hest, A., van Haaren, F. and van de Poll, N.E., The behavior of male and female Wistar rats pressing a lever for food is not affected by sex differences in food motivation, Behav. Brain Res., 27 (1988) 215-221.
182. van Hest, A., Stroet, J., van Haaren, F. and Feenstra, M., Scopolamine differentially disrupts the behaviour of male and female Wistar rats in a delayed nonmatching to position procedure, Pharmacol. Biochem. Behav., 35 (1990) 903-909.
183. Verbanac, J.S., Altamn, H.J., Dhingra, P., Harrington, G.M. and Commissaris, R.L., Conflict behavior in Maudsley reactive and non-reactive rats: effects of noradrenergic neuronal destruction, Pharmacol. Biochem. Behav., 45 (1993) 429-438.
184. Walsh, L.L., Differences in food, water, and food-deprivation water intake in 16 strains of rats, J. Comp. Physiol. Psychol., 94 (1980) 775-781.
185. Weindruch, R. and Masuro, E.J., Concerns about rodent models for aging research, J. Gerontol., 46 (1994) B87-B88.
186. Westenberg, I.S. and Bolam, J.M., Onset and duration of response to pentobarbital of pigmented versus albino rats: a within-strain comparison, Behav. Neural Biol., 33 (1981) 391-396.
187. Whishaw, I.Q. and Tomie, J.-A., Cholinergic receptor blockade produces impairments in a sensorimotor subsystem for place navigation in the rat: evidence from sensory, motor, and acquisition tests in a swimming pool, Behav. Neurosci., 101 (1987) 603-616.
188. Wieland, S., Boren, J.L., Consroe, P.F. and Martin, A., Stock differences in the susceptibility of rats to learned helplessness training, Life Sci., 39 (1986) 937-944.
189. Wilkinson, R.T., Interaction of noise with knowledge of results and sleep deprivation, J. Exp. Psychol., 66 (1963) 332-337.
190. Yau, J.L.W., Morris, R.G.M. and Seckl, J.R., Hippocampal corticosteroid receptor mRNA expression and spatial learning in the aged Wistar rat, Brain Res., 657 (1994) 59-64.
191. Yau, J.L.W., Olsson, T., Morris, R.G.M., Meaney, M.J. and Seckl, J.R., Glucocorticoids, hippocampal corticosteroid receptor gene expression and antidepressant treatment: relationship with spatial learning in young and aged rats, Neuroscience, 66 (1995) 571-581.
192. Young, G.D. and Wilson, J.F., Comparing matching ability, spatial memory, and ideational fluency in boys and girls, Percept. Mot. Skills, 79 (1994) 1019-1024.
193. Zyzak, D.R., Otto, T., Eichenbaum and Gallagher, M., Cognitive decline associated with normal aging in rats: a neuropsychological approach, Learn. Mem., 2 (1995) 1-16.