Effect of aging on tryptophan hydroxylase in rat brain: Implications on serotonin level

Drug Metabolism and Disposition

Volumn 28, Issue 9, 2000, Pages 1038-1042

  Hussain, Azher M ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

SEROTONIN; TRYPTOPHAN HYDROXYLASE;

AGED; AGING; ANIMAL EXPERIMENT; ARTICLE; BRAIN; CATALYSIS; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ENZYME ACTIVITY; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SEROTONINERGIC SYSTEM;

AGING; ANIMALS; BRAIN; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; KINETICS; MALE; MEDULLA OBLONGATA; MESENCEPHALON; PONS; RATS; RATS, INBRED F344; TRYPTOPHAN HYDROXYLASE;

EID: 0033835070     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Age-related changes in bindings of second messengers in the rat brain
2. Depression in elderly
3. Why tryptophan hydroxylase is difficult to purify: A reactive oxygen-derived species-mediated phenomenon that may be implicated in human pathology
4. Sequence of two mRNAs encoding active rat tryptophan hydroxylase
5. Protein damage and degradation by oxygen radicals
6. Oxidative inactivation of tyrosine hydroxylase in substantia nigra of aged rat
7. Differential control of tryptophan hydroxylase expression in raphe and in pineal gland: Evidence for a role of translation efficiency
8. Serotonin
9. Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain
10. Demonstration of the phosphorylation-dependent interaction of tryptophan hydroxylase with the 14-3-3 protein
11. Full length cDNA for rabbit tryptophan hydroxlase: Functional domains and evolution of aromatic amino acid hydroxylases
12. Effects of maturation and aging on calmodulin and calmodulin-regulated enzymes in various regions of mouse brain
13. Tryptophan hydroxylase inhibition: The mechanism by which p-chlorophenylalanine depletes brain serotonin
14. Phosphorylation and activation of tryptophan hydroxylase by endogenous protein kinase A
15. Molecular cloning and characterization of cDNA encoding tryptophan hydroxylase from rat central serotonergic neuron
16. Phosphorylation and activation of brain tryptophan hydroxyalse: Identification of serine-58 as a substrate site for protein kinase A
17. Interrelationship of age, depression, and central serotonergic function: Evidence from fenfluramine challenge studies
18. Protein measurement with the folin phenol reagent
19. Aging-induced changes in actylcholine and serotonin content of discreate brain nuclie
20. Purification and properties of tryptophan 5- monooxygenase from rat brain-stem
21. Activation of adenylate cyclase by dopamine, GPT, NaF and forskolin in striatal membranes of neonatal, adult and senescent rats
22. Neurotransmitter changes in Alzheimer's disease: Implications to diagnostics and therapy
23. Changes in biogenic amines in rat hippocampus during development and aging
24. Age changes in some physiologic processes
25. Age-associated alteration of serotonergic synaptic neurochemistry in rat rostral hypothalamus
26. Age-related changes of cyclic AMP phosphodiesterase acitivity in rat brain regions and a new phosphodiesterase inhibitor-nootropic agent adafenoxate
27. Measurement of tryptophan hydroxylase activity in rat pineal glands and pinealocytes using an HPLC assay with electrochemical detection
28. Effect of aging on the kinetics of blood-brain barrier uptake of tryptophan in rats
29. Calmodulin content in different brain areas of aging rats
30. High level expression and deletion mutagenesis of human tryptophan hydroxylase