Agonist-independent activation of G(z) by the 5-hydroxytryptamine(1A) receptor co-expressed in Spodoptera frugiperda cells. Distinguishing inverse agonists from neutral antagonists

Journal of Biological Chemistry

Volumn 272, Issue 52, 1997, Pages 32979-32987

  Barr, Alastair J ^a   Manning, David R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIBUTYLAMINO 8 HYDROXYTETRALIN; GUANINE NUCLEOTIDE BINDING PROTEIN; LIGAND; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; RADIOLIGAND; SEROTONIN; SEROTONIN 1A RECEPTOR; SPIPERONE;

ARTICLE; BACULOVIRUS; BINDING AFFINITY; COMPETITIVE INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOPRECIPITATION; LEPIDOPTERA; NONHUMAN; PRIORITY JOURNAL; QUANTITATIVE ASSAY; RECEPTOR BINDING; SCATCHARD PLOT; SEROTONINERGIC SYSTEM; VIRUS RECOMBINANT;

AMINOPYRIDINES; ANIMALS; ENZYME INHIBITORS; GTP-BINDING PROTEIN ALPHA SUBUNITS; GTP-BINDING PROTEINS; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; KINETICS; LIGANDS; PIPERAZINES; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN ANTAGONISTS; SPIPERONE; SPODOPTERA; TETRAHYDRONAPHTHALENES;

LEPIDOPTERA; MAMMALIA; SPODOPTERA FRUGIPERDA; UNIDENTIFIED BACULOVIRUS;

EID: 0031468622     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.52.32979     Document Type: Article

References (59)

1. Hoyer, D., Clarke, D. E., Fozard, J. R., Hartig, P. R., Martin, G. R., Mylecharane, E. J., Saxena, P. R., and Humphrey, P. P. A. (1994) Pharmacol. Rev. 46, 157-203
2. Cowen, D. S., Sowers, R. S., and Manning, D. R. (1996) J. Biol. Chem. 271, 22297-22300
3. Cowen, D. S., Molinoff, P. B., and Manning, D. R. (1997) Mol. Pharmacol. 52, 221-226
4. Garnovskaya, M. N., Gettys, T. W., van Biesen, T., Prpic, V., Chuprun, J. K., and Raymond, J. R. (1997) J. Biol. Chem. 272, 7770-7776
5. Strathmann, M. P., and Simon, M. I. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 5582-5586
6. Fargin, A., Raymond, J. R., Regan, J. W., Cotecchia, S., Lefkowitz, R. J., and Caron, M. G. (1989) J. Biol. Chem. 264, 14848-14852
7. Liu, Y. F., and Albert, P. R. (1991) J. Biol. Chem. 266, 23689-23697
8. Kobilka, B. K., Frielle, T., Collins, S., Yang-Feng, T., Kobilka, T. S., Francke, U., Lefkowitz, R. J., and Caron, M. G. (1987) Nature 329, 75-79
9. Fargin, A., Raymond, J. R., Lohse, M. J., Kobilka, B. K., Caron, M. G., and Lefkowitz, R. J. (1988) Nature 335, 358-360
10. Fletcher, A., Cliffe, I. A., and Dourish, C. T. (1993) Trends Pharmacol. Sci. 14, 441-448
11. Gozlan, H., Mestikawy, S. E., Pichat, L., Glowinski, J., and Hamon, M. (1983) Nature 305, 140-142
12. Zhuang, Z.-P., Kung, M.-P., and Kung, H. F. (1993) J. Med. Chem. 36, 3161-3165
13. Zhuang, Z.-P., Kung, M.-P., and Kung, H. F. (1994) J. Med. Chem. 37, 1406-1407
14. Kung, H. F., Kung, M.-P., Clarke, W., Maayani, S., and Zhuang, Z.-P. (1994) Life Sci. 55, 1459-1462
15. Kung, M.-P., Frederick, D., Mu, M., Zhuang, Z.-P., and Kung, H. F. (1995) J. Pharmacol. Exp. Ther. 272, 429-437
16. Kung, H. F., Stevenson, D. A., Zhuang, Z.-P., Kung, M.-P., Frederick, D., and Hurt, S. D. (1996) Synapse 23, 344-346
17. Leysen, J. E., Gommeren, W., and Laduron, P. M. (1978) Biochem. Pharmacol. 27, 307-316
18. Leysen, J. E., Niemegeers, C. J. E., Tollenaere, J. P., and Laduron, P. M. (1978) Nature 272, 168-171
19. Hall, M. D., El Mestikawy, S., Emerit, M. B., Pichat, L., Hamon, M., and Gozlan, H. (1985) J. Neurochem. 44, 1685-1696
20. Peroutka, S. J. (1986) J. Neurochem. 47, 529-540
21. Hensler, J. G., Cervera, L. S., Miller, H. A., and Corbitt, J. (1996) J. Pharmacol. Exp. Ther. 278, 1138-1145
22. Albert, P. R., Zhou, Q.-Y., Van Tol, H. H. M., Bunzow, J. R., and Civelli, O. (1990) J. Biol. Chem. 265, 5825-5832
23. Guan, X.-M., Peroutka, S. J., and Kobilka, B. K. (1992) Mol. Pharmacol. 41, 695-698
24. Sundaram, H., Newman-Tancredi, A., and Strange, P. G. (1993) Biochem. Pharmacol. 45, 1003-1009
25. Raymond, J. R., Fargin, A., Lohse, M. J., Regan, J. W., Senogles, S. E., Lefkowitz, R. J., and Caron, M. G. (1989) Mol. Pharmacol. 36, 15-21
26. Costa, T., and Herz, A. (1989) Proc. Natl. Acad. Sci. U. S. A. 86, 7321-7325
27. Tian, W. N., Duzic, E., Lanier, S. M., and Deth, R. C. (1994) Mol. Pharmacol. 45, 524-531
28. Hilf, G., and Jakobs, K. H. (1992) Eur. J. Pharmacol. 225, 245-252
29. Tiberi, M., and Caron, M. G. (1994) J. Biol. Chem. 269, 27925-27931
30. Samama, P., Cotecchia, S., Costa, T., and Lefkowitz, R. J. (1993) J. Biol. Chem. 268, 4625-4636
31. Thomas, D. R., Faruq, S. A., Balcarek, J. M., and Brown, A. M. (1995) J. Recept. Sign. Transd. Res. 15, 199-211
32. Barker, E. L., Westphal, R. S., Schmidt, D., and Sanders-Bush, E. (1994) J. Biol. Chem. 269, 11687-11690
33. Milano, C. A., Allen, L. F., Rockman, H. A., Dolber, P. C., McMinn, T. R., Chien, K. R., Johnson, T. D., Bond, R. A., and Lefkowitz, R. J. (1994) Science 264, 582-586
34. Kjelsberg, M. A., Cotecchia, S., Ostrowski, J., Caron, M. G., and Lefkowitz, R. J. (1992) J. Biol. Chem. 267, 1430-1433
35. Robinson, P. R., Cohen, G. B., Zhukovsky, E. A., and Oprian, D. D. (1992) Neuron 9, 719-725
36. Robbins, L. S., Nadeau, J. H., Johnson, K. R., Kelly, M. A., Roselli-Rehfuss, L., Baack, E., Mountjoy, K. G., and Cone, R. D. (1993) Cell 72, 827-834
37. Lefkowitz, R. J., Cotecchia, S., Samama, P., and Costa, T. (1993) Trends Pharmacol. Sci. 14, 303-307
38. Kenakin, T. (1996) Pharmacol. Rev. 48, 413-463
39. Braestrup, C., Schmiechen, R., Neef, G., Nielsen, M., and Petersen, E. N. (1982) Science 216, 1241-1243
40. Chidiac, P., Hebert, T. E., Valiquette, M., Dennis, M., and Bouvier, M. (1994) Mol. Pharmacol. 45, 490-499
41. Labrecque, J., Fargin, A., Bouvier, M., Chidiac, P., and Dennis, M. (1995) Mol. Pharmacol. 48, 150-159
42. Samama, P., Pei, G., Costa, T., Cotecchia, S., and Lefkowitz, R. J. (1994) Mol. Pharmacol. 45, 390-394
43. Bond, R. A., Leff, P., Johnson, T. D., Milano, C. A., Rockman, H. A., McMinn, T. R., Apparsundaram, S., Hyek, M. F., Kenakin, T. P., Allen, L. F., and Lefkowitz, R. J. (1995) Nature 374, 272-276
44. Parker, E. M., Kameyama, K., Higashijima, T., and Ross, E. M. (1991) J. Biol. Chem. 266, 519-527
45. Mulheron, J. G., Casanas, S. J., Arthur, J. M., Garnovskaya, M. N., Gettys, T. W., and Raymond, J. R. (1994) J. Biol. Chem. 269, 12954-12962
46. Parker, E. M., Grisel, D. A., Iben, L. G., Nowak, H. P., Mahle, C. D., Yocca, F. D., and Gaughan, G. T. (1994) Eur. J. Pharmacol. 268, 43-53
47. Butkerait, P., Zheng, Y., Hallak, H., Graham, T. E., Miller, H. A., Burris, K. D., Molinoff, P. B., and Manning, D. R. (1995) J. Biol. Chem. 270, 18691-18699
48. Hartman, J. L., and Northup, J. K. (1996) J. Biol. Chem. 271, 22591-22597
49. Barr, A. J., Brass, L. F., and Manning, D. R. (1997) J. Biol. Chem. 272, 2223-2229
50. Iniguez-Lluhi, J. A., Simon, M. I., Robishaw, J. D., and Gilman, A. G. (1992) J, Biol. Chem. 267, 23409-23417
51. Lounsbury, K. M., Casey, P. J., Brass, L. F., and Manning, D. R. (1991) J. Biol. Chem. 266, 22051-22056
52. Kreiss, D. S., Wieland, S., and Lucki, I. (1993) Neuroscience 52, 295-301
53. Wreggett, K. A., and De Léan, A. (1984) Mol. Pharmacol. 26, 214-227
54. Scatchard, G. (1949) Ann. N. Y. Acad. Sci. 51, 660-672
55. Wong, Y. H., Conklin, B. R., and Bourne, H. R. (1992) Science 255, 339-342
56. Lai, H. W. L., Minami, M., Satoh, M., and Wong, Y. H. (1995) FEBS Lett. 360, 97-99
57. Kenakin, T., Pharmacologie Analysis of Drug Receptor Interaction, 2nd Ed., pp. 334-335, Raven Press, New York, 1993
58. Sundaram, H., Turner, J. D., and Strange, P. G. (1995) J. Neurochem. 65, 1909-1916
59. Newman-Tancredi, A., Conte, C., Chaput, C., Spedding, M., and Millan, M. J. (1997) Br. J. Pharmacol. 120, 737-739