Inhibition of the constitutive activity of human 5-HT1A receptors by the inverse agonist, spiperone but not the neutral antagonist, way 100,635

British Journal of Pharmacology

Volumn 120, Issue 5, 1997, Pages 737-739

  Newman Tancredi, Adrian ^a   Conte, Caroline ^a   Chaput, Christine ^a   Spedding, Michael ^a   Millan, Mark J ^a  

^a INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

Constitutive activity; G proteins; HT1a receptors; Inverse agonism; WAY; 35S GTP S binding

Indexed keywords

5 CARBAMOYLTRYPTAMINE; 5-CARBOXAMIDOTRYPTAMINE; DRUG DERIVATIVE; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; PIPERAZINE DERIVATIVE; PYRIDINE DERIVATIVE; RECOMBINANT PROTEIN; SEROTONIN; SEROTONIN 1 RECEPTOR; SEROTONIN AGONIST; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; SPIPERONE; SULFUR;

ANIMAL; ARTICLE; CHO CELL; DRUG EFFECT; HAMSTER; HUMAN; METABOLISM; RADIOASSAY;

ANIMALS; CHO CELLS; CRICETINAE; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HUMANS; PIPERAZINES; PYRIDINES; RADIOLIGAND ASSAY; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RECOMBINANT PROTEINS; SEROTONIN; SEROTONIN AGONISTS; SEROTONIN ANTAGONISTS; SPIPERONE; SULFUR RADIOISOTOPES;

EID: 0031092162     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701025     Document Type: Article

References (8)

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