ABCA1: Regulation, function and relationship to atherosclerosis

Current Opinion in Investigational Drugs

Volumn 3, Issue 3, 2002, Pages 415-419

  Francone, Omar L ^a   Aiello, Robert J ^a  

^a PFIZER INC   (United States)

Author keywords

Atherosclerosis; ATP binding cassette transporter A1; Cholesterol efflux; High density lipoprotein; Macrophage; Tangier disease

Indexed keywords

ABC TRANSPORTER; ABC TRANSPORTER A1; APOPROTEIN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PHOSPHOLIPID; UNCLASSIFIED DRUG;

ATHEROSCLEROSIS; BIOSYNTHESIS; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL SYNTHESIS; CHOLESTEROL TRANSPORT; DISEASE COURSE; DRUG EFFECT; GENE MUTATION; HOMEOSTASIS; HUMAN; NONHUMAN; PATHOGENESIS; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; TANGIER DISEASE;

ANIMALS; ARTERIOSCLEROSIS; ATP-BINDING CASSETTE TRANSPORTERS; CHOLESTEROL, HDL; HUMANS;

EID: 0036232095     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (42)

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2. ABC transporters: Bacterial exporters-revisited five years on
3. The ABCA subclass of mammalian transporters
4. The human ATP-binding cassette (ABC) transporter superfamily
5. The human ATP-binding cassette (ABC) transporter superfamily
6. The ATP binding casette transporter ABC1 is required for the engulfment of corpses generated by apoptotic cell death
7. Molecular cloning of the human ATP binding cassette transporter 1 (hABC1): Evidence for sterol-dependent regulation in macrophages
8. The correlation of ATP-binding cassette 1 mRNA levels with cholesterol efflux from various cell lines
9. ABC1, an ATP binding cassette transporter required for phagocytosis of apoptotic cells, generates a regulated anion flux after expression in Xenopus laevis oocytes
10. Interferon-gamma induces downregulation of Tangier disease gene (ATP-binding-cassette transporter 1) in macrophage-derived foam cells
11. Regulation of absorption and ABC1-mediate efflux of cholesterol by RXR heterodimers
12. Sterol-dependent transactivation of the ABC1 promoter by the liver X receptor/retinoid X receptor
13. Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha
14. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
15. PPAR-α and PPAR-γ activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
16. ABCA1 is the cAMP-inducible apolipoprotein receptor that mediates cholesterol secretion from macrophages
17. Identification of cAMP analogue inducible genes in RAW264 macrophages
18. Interleukin-1β secretion is impaired by inhibitors of the ATP binding cassette transporter, ABC1
19. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency
20. The gene encoding ATP binding cassette transporter 1 is mutated in Tangier disease
21. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1
22. High density lipoprotein deficiency and foam cell accumulation in mice with targeted disruption of ATP-binding cassette transporter-1
23. Functional loss of ABCA1 in mice causes severe placenta malformation, aberrant lipid distribution, and kidney glomerulonephritis as well as high-density lipoprotein cholesterol deficiency
24. Cloning of two novel ABC transporters mapping on human chromosome 9
25. Apolipoprotein specificity for lipid efflux by the human ABCA1 transporter
26. Early incorporation of cell-derived cholesterol into pre-beta-migrating high-density lipoprotein
27. Distribution and functions of lecithin: Cholesterol acyltransferase and cholesteryl ester transfer protein in plasma lipoproteins
28. Monocyte/macrophage expression of ABCA1 has minimal contribution to plasma HDL levels
29. Regulation and activity of the human ABCA1 gene in transgenic mice
30. ABCA1 overexpression leads to hyperalphalipoproteinemia and increased biliary cholesterol excretion in transgenic mice
31. Human ABCA1 BAC transgenic mice show increased high density lipoprotein cholesterol and ApoAI-dependent efflux stimulated by an internal promoter containing liver X-receptor response elements in intron 1
32. Familial HDL deficiency: Tangier disease
33. Coronary heart disease prevalence and other clinical features in familial high-density lipoprotein deficiency (Tangier disease)
34. Coronary artery disease in 116 kindreds with familial type II hyperlipoproteinemia
35. Spontaneous high density lipoprotein deficiency syndrome associated with a Z-linked mutation in chickens
36. Tangier disease and ABCA1
37. Hepatobiliary cholesterol transport is not impaired in ABCA1-null mice lacking HDL
38. Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
39. Absence of p-selectin, but not intercellular adhesion molecule-1, attenuates neointimal growth after arterial injury in lipoprotein E-deficient mice
40. Evidence for an altered lipid metabolic state in circulating blood monocytes under conditions of hyperlipidemia in swine and its implications in arterial lipid metabolism
41. Chemokine receptor CCR2 expression and monocyte chemoattractant protein-1-mediated chemotaxis in human monocytes. A regulatory role for plasma LDL
42. ATP-binding cassette transporter A1 (ABCA1) in macrophages: A dual function in inflammation and lipid metabolism?