Interferon-γ induces downregulation of tangier disease gene (ATP- binding-cassette transporter 1) in macrophage-derived foam cells

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 20, Issue 6, 2000, Pages 1565-1571

  Panousis, Constantinos G ^a   Zuckerman, Steven H ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Apolipoprotein A I; ATP binding cassette transporter 1; Cholesterol efflux; Interferon

Indexed keywords

ADENOSINE TRIPHOSPHATE; APOLIPOPROTEIN A1; GAMMA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTING CELL; ARTICLE; CHOLESTEROL TRANSPORT; FIBROBLAST; FOAM CELL; GENE CASSETTE; INTERNALIZATION; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; SECOND MESSENGER; TANGIER DISEASE;

EID: 0034080596     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.20.6.1565     Document Type: Article

References (47)

1. Von Eckardstein A. Cholesterol efflux from macrophages and other cells. Curr Opin Lipidol. 1996;7:308-319.
2. Brown MS, Goldstein JL. A receptor mediated pathway for cholesterol homeostasis. Science. 1986;232:34-47.
3. Brown MS, Goldstein JL. Lipoprotein metabolism in the macrophages: implications for cholesterol deposition in atherosclerosis. Annu Rev Biochem. 1983;52:223-261.
4. Tall AR. An overview of reverse cholesterol transport. Eur Heart J. 1998;19(suppl A):A31-A35.
5. Rothblat GH, Mahlberg FH, Jonhson WJ, Phillips MC. Apolipoproteins, membrane cholesterol domains, and the regulation of cholesterol efflux. J Lipid Res. 1992;33:1091-1097.
6. Ji Y, Jian B, Wang N, Sun Y, Moya ML, Phillips MC, Rothblat GH, Swaney JB, Tall AR. Scavenger receptor BI promotes high density lipoprotein-mediated cellular cholesterol efflux. J Biol Chem. 1997;272: 20982-20985.
7. de la Llera-Moya M, Rothblat GH, Connelly MA, Kellner-Weibel G, Sakr SW, Phillips MC, Williams DL. Scavenger receptor BI (SR-BI) mediates free cholesterol flux independently of HDL tethering to the cell surface. J Lipid Res. 1999;40:575-580.
8. Oram JF, Yokoyama S. Apolipoprotein-mediated removal of cellular cholesterol and phospholipids. J Lipid Res. 1996;37:2473-2491.
9. Mendez AJ. Cholesterol efflux mediated by apolipoproteins is an active process distinct from efflux mediated by passive diffusion. J Lipid Res. 1997;38:1807-1821.
10. Fredrickson DS, Altrocchi PH, Avioli LV, Goodman DS, Goodman HC. Tangier disease-combined clinical staff conference at the National Institutes of Health. Ann Intern Med. 1961;55:1016-1021.
11. Assman G, von Eckardstein A, Brewer HB Jr. Familial HDL deficiency: Tangier disease. In: Scriver CR, Beaudet AL, Sly WS, Valle D, eds. The Metabolic and Molecular Basis of Inherited Disease. 7th ed. New York, NY: McGraw-Hill: 1995:2053-2072.
12. Francis GA, Knopp RH, Oram JF. Defective removal of cellular cholesterol and phospholipid by apolipoprotein A-I in Tangier disease. J Clin Invest. 1995;96:78-87.
13. Bodzioch M, Orso E, Klucken J, Langman T, Bottcher A, Diederich W, Drobnik W, Barlage S, Buchler C, Porsch-Ozcurumez M, et al. The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat Genet. 1999;22:347-351.
14. Rust S, Rosier M, Funke H, Real J, Amoura Z, Piette JC, Deleuze JF, Brewer HB, Duvenger N, Denefle P, et al. Tangier disease is caused by mutations in the gene encoding ATP-binding cassette transporter 1. Nat Genet. 1999;22:352-355.
15. Brooks-Wilson A, Marcil M, Clee SM, Zhang LH, Roomp K, van Dam M, Yu L, Brewer C, Collins JA, Molhuizen HOF, et al. Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency. Nat Genet. 1999;22:336-345.
16. Hokland BM, Slotte JP, Johnson TF. Cyclic AMP stimulates efflux of intracellular sterol from cholesterol-loaded cells. J Biol Chem. 1993;268: 25343-25349.
17. Langmann T, Klucken J, Reil M, Liebisch G, Luciani MF, Chimini G, Kaminski WE, Smitz G. Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): evidence for sterol-dependent regulation in macrophages. Biochem Biophys Res Commun. 1999;275:29-33.
18. Lawn RM, Wade DP, Garvin MR, Wang X, Schwartz K, Porter JG, Seilhamer JJ, Vaughan AM, Oram JF. The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway. J Clin Invest. 1999;104:R25-R31.
19. Panousis CG, Zuckerman SH. Regulation of cholesterol distribution in macrophage-derived foam cells by interferon-γ. J Lipid Res. 2000;41: 75-83.
20. Hansson GK, Holm J, Jonasson L. Detection of activated T lymphocytes in the human atherosclerotic plaque. Am J Pathol. 1989;135: 169-175.
21. Geng YJ, Holm J, Nygren S, Bruzelius M, Stemme S, Hansson GK. Expression of macrophage scavenger receptor in atherosclerosis: relationship between scavenger receptor isoforms and the T cell cytokine, interferon-γ. Arterioscler Thromb Vasc Biol. 1995;15:1995-2002.
22. Ross R. Atherosclerosis: an inflammatory disease. N Engl J Med. 1999; 340:115-126.
23. Gupta S, Pablo AM, Jiang XC, Wang N, Tall AR, Schindler C. IFN-γ potentiates atherosclerosis in apoE knockout mice. J Clin Invest. 1997; 91:1219-1224.
24. Trowsdale J, Hanson I, Mockridge I, Beck S, Townsend A, Kelly A. Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters. Nature. 1990;348:741-744.
25. Epperson DE, Arnold D, Spies T, Cresswell P, Pober JS, Jonhson DR. Cytokines increase transporter in antigen processing-1 expression more rapidly than HLA class I expression in endothelial cells. J Immunol. 1992;149:3297-3301.
26. Bligh EG, Dyer WJ. A rapid method of total lipid extraction and purification. Can J Biochem Phys. 1959;37:911-917.
27. Soares MB, De Fatima-Bonaldo M, Jelene P, Su L, Lawton L, Efstratiadis A. Construction and characterization of a normalized cDNA library. Proc Natl Acad Sci U S A. 1994;91:9228-9232.
28. Hansson GK. Cell-mediated immunity in atherosclerosis. Curr Opin Lipidol. 1997;8:301-311.
29. Daugherty A, Pure E, Delfel-Butteiger D, Shen S, Leferovich J, Roselaar SE, Rader DJ. The effects of lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E-/-mice. J Clin Invest. 1997;100: 1575-1580.
30. Geng Y, Hansson GK. Interferon-γ inhibits scavenger receptor expression and foam cell formation in human monocyte-derived macrophages. J Clin Invest. 1992;89:1322-1330.
31. LaMarre J, Wolf BB, Kittler EL, Quesenberry PJ, Gonias SL. Regulation of macrophage α-2-macroglobulin receptor/low density lipoprotein receptor-related protein by lipopolysaccharide and interferon-γ. J Clin Invest. 1993;91:1219-1224.
32. Querfeld U, Ong JM, Prehn J, Carty J, Saffari B, Jordan SC, Kern PA. Effects of cytokines on the production of lipoprotein lipase in cultured human macrophages. J Lipid Res. 1990;31:1379-1386.
33. Li H, Cybulsky MI, Gimbrone MA, Libby P. An atherogenic diet rapidly induces VCAM-I, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler Thromb Vasc Biol. 1993;13:197-204.
34. Jonasson L, Holm J, Skalli O, Gabiani G, Hansson GK. Expression of class II transplantation antigen on vascular smooth muscle cells in human atherosclerosis. J Clin Invest. 1985;76:125-131.
35. Li H, Freeman MW, Libby P. Regulation of smooth muscle cell scavenger receptor expression in vivo by atherogenic diets and in vitro by cytokines. J Clin Invest. 1995;95:122-133.
36. Whitman SC, Argmann CA, Sawyez CG, Miller DB, Hegele RA, Huff MW. Uptake of type IV hypertriglyceridemic VLDL by cultured macrophages is enhanced by interferon-γ. J Lipid Res. 1999;40: 1017-1028.
37. Luciani MF, Denizot F, Savary S, Mattei MG, Chimini G. Cloning of two novel ABC transporters mapping on human chromosome 9. Genomics. 1994;21:150-159.
38. Luciani MF, Chimini G. The ATP binding cassette transporter ABC1, is required for the engulfment of corpses generated by apoptotic cell death. EMBO J. 1996;15:226-235.
39. Hara H, Yokoyama S. Interaction of free apolipoproteins with macrophages. J Biol Chem. 1990;266:3080-3086.
40. Li Q, Komada A, Yokoyama S. Cholesterol is poorly available for free apolipoprotein-mediated cellular lipid efflux from smooth muscle cells. Biochemistry. 1993;32:4597-4603.
41. Freeman WF. Effluxed lipids: Tangier Island's latest export. Proc Natl Acad Sci U S A. 1999;96:10950-10952.
42. Young SG, Fielding CJ. The ABCs of cholesterol efflux. Nat Genet. 1999;22:316-318.
43. Oude Elferink RPJ, Tytgat GNJ, Groen AK. Hepatic canalicular membrane 1: the role of mdr2 P-glycoprotein in hepatobiliary lipid transport. FASEB J. 1997;11:19-28.
44. Sakr SW, Williams DL, Stoudt GW, Phillips MC, Rothblat GH. Induction of cellular cholesterol efflux to lipid-free apolipoprotein AI by cAMP. Biochim Biophys Acta. 1999;1438:85-98.
45. Takahashi Y, Smith JD. Cholesterol efflux to apolipoprotein AI involves endocytosis and resecretion in a calcium-dependent pathway. Proc Natl Acad Sci U S A. 1999;96:11358-11363.
46. Wang F, Sengupta TK, Zhong Z, Ivashkiv LB. Regulation of the balance of cytokine production and the signal transducer and transcription (STAT) transcription factor activity by cytokines and inflammatory synovial fluids. J Exp Med. 1995;182:1825-1831.
47. Grewal T, Boudreau M, Roy M, Chamberland A, Lefebvre C, Lavigne J, Davingon J, Minnich A. Expression of γ-IFN responsive genes in scavenger receptor over-expressing monocytes is associated with xanthomatosis. Atherosclerosis. 1998;138:335-345.