ATP-binding cassette transporter A1 (ABCA1) in macrophages: A dual function in inflammation and lipid metabolism?

Pathobiology

Volumn 67, Issue 5-6, 1999, Pages 236-240

  Schmitz, Gerd ^a   Kaminski, W E ^b   Porsch Ozcurumez M ^b   Klucken, J ^b   Orso E ^b   Bodzioch, M ^b   Buchler C ^b   Drobnik, W ^b  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

^b NONE

Author keywords

ABC transporter; ABCA1; HDL; Lipid; Macrophage

Indexed keywords

ABC TRANSPORTER; CHOLESTEROL ESTER; HIGH DENSITY LIPOPROTEIN; INTERLEUKIN 1; INTERLEUKIN 1BETA; LOW DENSITY LIPOPROTEIN;

APOPTOSIS; ATHEROSCLEROSIS; CELL DIFFERENTIATION; CONFERENCE PAPER; CONTROLLED STUDY; DISORDERS OF LIPID AND LIPOPROTEIN METABOLISM; GENE LOCATION; GENE MUTATION; GENETIC ANALYSIS; HUMAN; HUMAN CELL; HYPERSPLENISM; INFLAMMATION; MACROPHAGE; MAJOR CLINICAL STUDY; MONOCYTE; PRIORITY JOURNAL; RETICULOENDOTHELIAL SYSTEM; TANGIER DISEASE;

EID: 0342905416     PISSN: 10152008     EISSN: None     Source Type: Journal    
DOI: 10.1159/000028100     Document Type: Conference Paper

References (5)

1. Bodzioch M, Orso E, Klucken J, Langmann T, Böttcher A, Diederich W, Drobnik W. Barlage S, Büchler C, Porsch-Özcürümez M, Kaminski WE, Hahmann HW, Ötte K, Rothe G, Aslanidis C, Lackner KJ, Schmitz G: The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease. Nat Genet 1999;22: 347-351.
2. Klucken J, Büchler C, Orsó E, Kaminski WE, Porsch-Özcürümez M, Liebisch G, Kapinsky M, Diederich W, Drobnik W, Dean M, Allikmets R, Chimini G, Schmitz G: ABCG1 (ABC8), the human homolog of the drosophila white gene, isa regulator of macrophage cholesterol and phospholipid transport. Proc Natl Acad Sci USA, in press.
3. Langmann T, Klucken R, Reil M, Liebisch G, Luciani MF, Chimini G, Kaminski WE, Schmitz G: Molecular cloning of the human ATP-binding cassette transporter 1 (hABC1): Evidence for sterol-dependent regulation in macrophages. Biochem Biophys Res Commun 1999;257/1:29-33.
4. Hamon Y, Luciani MF, Becq F, Verrier B, Rubartelli A, Chimini G: Interleukin-1beta secretion is impaired by inhibitors of the Atp binding cassette transporter, ABC1. Blood 1997;90:2911-2915.
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