Effects of perinatal exposure to flutamide on sex hormones and androgen-dependent organs in F1 male rats

Journal of Toxicological Sciences

Volumn 27, Issue 1, 2002, Pages 19-33

  Miyata, Kaori ^a   Yabushita, Setsuko ^a   Sukata, Tokuo ^a   Sano, Masashi ^b   Yoshino, Hiroko ^b   Nakanishi, Takumi ^b   Okuno, Yasuyoshi ^a   Matsuo, Masatoshi ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

^b Daiyukai Research Institute for Medical Science   (Japan)

Author keywords

Antiandrogen; Flutamide; Male rats; Perinatal

Indexed keywords

ANDROGEN; FLUTAMIDE; FOLLITROPIN; LUTEINIZING HORMONE; SEX HORMONE; TESTOSTERONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AZOOSPERMIA; BODY WEIGHT; CONTROLLED STUDY; CRYPTORCHISM; ECTOPIC TESTIS; EXPOSURE; FEMALE; GESTATIONAL AGE; HISTOPATHOLOGY; HYPOSPADIAS; INFLAMMATION; LEVATOR ANI MUSCLE; MALE; NONHUMAN; ORGAN WEIGHT; PENIS DISEASE; PERINATAL CARE; PREGNANCY; PROSTATE; RAT; SEMEN ANALYSIS; SEMINAL VESICLE; SEMINIFEROUS TUBULE; SQUAMOUS CELL METAPLASIA; TESTIS DESCENT; UROGENITAL TRACT MALFORMATION;

ANIMALIA;

EID: 0036213832     PISSN: 03881350     EISSN: 18803989     Source Type: Journal    
DOI: 10.2131/jts.27.19     Document Type: Article

References (47)

1. Lack of effects for low dose levels of bisphenol A and diethylstilbestrol on the prostate gland of CF 1 mice exposed in utero
2. Permanent effects of neonatal estrogen exposure in rats on reproductive hormone levels, Sertoli cell number, and the efficiency of spermatogenesis in adulthood
3. Properties of sufficiency and statistical tests
4. Immunohistochemical localization of androgen receptors in the rat testis: Evidence for stage-dependent expression and regulation by androgens
5. Normal reproductive organ development in Wistar rats exposed to bisphenol A in the drinking water
6. Normal reproductive organ development in CF-1 mice following prenatal exposure to bisphenol A
7. Hormonal mechanisms in male reproductive tract toxicity
8. New tables for multiple comparisons with a control
9. Effect of different sampling designs on outcome of endocrine disruptor studies
10. Developmental effects of an environmental antiandrogen: The fungicide vinclozolin alters sex differentiation of the male rat
11. Environmental antiandrogens: Low dose of the fungicide vinclozolin alter sexual differentiation of the male rat
12. Administration of potentially antiandrogenic pesticides (procymidone, linuron, iprodione, chlozolinate, p,p'-DDE, and ketoconazole) and toxic substances (dibutyl- and diethylhexyl phthalate, PCB 169, and ethane dimethane sulphonate) during sexual differentiation produces diverse profiles of reproductive malformations in the male rat
13. Perinatal exposure to the phthalates DEHP, BBP, and DINP, but not DEP, DMP, or DOTP, alters sexual differentiation of the male rat
14. Reproductive malformation of the male offspring following maternal exposure to estrogenic chemicals
15. Exposure to bisphenol A advances puberty
16. Comparison of the effects of the 5α-reductase inhibitor finasteride and the antiandrogen flutamide on prostate and genital differentiation: Dose-response studies
17. Epididymal sperm motion as a parameter of male reproductive toxicity: Sperm motion, fertility, and histopathology in ethinylestradiol-treated
18. The effects of pre- and postnatal exposure to the nonsteroidal antiandrogen flutamide on testis descent and morphology in the Albino Swiss rat
19. Environmental hormone disruptors: Evidence that vinclozolin developmental toxicity is mediated by antiandrogenic metabolites
20. Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist
21. Vinclozolin and p,p'-DDE alter androgen-dependent gene expression: In vivo confirmation of an androgen receptor-mediated mechanisms
22. Perinatal fenvalerate exposure: Behavioral and endocrinology changes in male rats
23. Male reproductive tract malformations in rats following gestational and lactational exposure to di(n-butyl) phthalate: An antiandrogenic mechanism?
24. Disruption of androgen-regulated male reproductive development by di(n-butyl) phthalate during late gestation in rats is different from flutamide
25. Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol
26. An ongoing validation of a Tier I screening battery for detecting endocrine-active compounds (EACs)
27. Effects of an endocrine disruptor on male reproductive organs
28. The fungicide procymidone alters sexual differentiation in the male rat by acting as an androgen-receptor antagonist in vivo and in vitro
29. The plasticizer diethylhexyl phthalate induces malformations by decreasing fetal test-osterone synthesis during sexual differentiation in the male rat
30. 17 Beta-estradiol induced prostatitis in the rat is an autoimmune disease
31. Soy of dietary source plays a preventive role against the pathogenesis of prostatitis in rats
32. A multiple comparison rank sum test: Treatment versus control
33. Secretory immune system of the male reproductive tract: Effects of dihydrotestosterone and estradiol on IgA and secretory component levels
34. Perinatal exposure to estrogenic compounds and the subsequent effects on the prostate of the adult rat: Evaluation of inflammation in the ventral and lateral lobes
35. Repeated dose (28days) oral toxicity study of flutamide in rats, based on the draft protocol for the 'Enhanced OECD Test Guideline 407' for screening for endocrine-disrupting chemicals
36. Two-generation reproduction study with paratert-octylphenol in rats
37. Disturbed testicular descent in the rat after prenatal exposure to the antiandrogen flutamide
38. A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior
39. Sexual differentiation
40. Characterization of the period of sensitivity of fetal male sexual development to vinclozoline
41. Comparative evaluation of a 5-day Hershberger Assay utilizing mature male rats and a 20-day assay utilizing immature intact male rats for detection of flutamide's antiandrogenic activity
42. Impaired male sexual development in perinatal Sprague-Dawley and Long-Evans hooded rats exposed in utero and lactationally to p,p'-DDE
43. In utero exposure to antiandrogens alters the responsiveness of the prostate to p,p'-DDE in adult rats and may induce prostatic inflammation