Effect of different sampling designs on outcome of endocrine disruptor studies

Reproductive Toxicology

Volumn 14, Issue 4, 2000, Pages 359-367

  Elswick, Barbara A ^a   Welsch, Frank ^a   Janszen, Derek B ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

Author keywords

Bisphenol A; di n butyl phthalate; Endocrine disruptor; False negative; False positive; Intralitter variability; Sampling design; Statistical modeling; Ventral prostate

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ANTIESTROGEN; DRINKING WATER; ESTROGEN; PHENOL DERIVATIVE; PHTHALIC ACID DIBUTYL ESTER;

ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COMPUTER SIMULATION; CONTROLLED STUDY; DOSE RESPONSE; DRINKING; DRUG EFFECT; ENDOCRINE SYSTEM; FEEDING; FEMALE; MALE; METHODOLOGY; MODEL; NONHUMAN; ORGAN WEIGHT; PATHOLOGY; PREGNANCY; PROGENY; PROSTATE; RAT; RAT STRAIN; REPRODUCIBILITY; REPRODUCTIVE TOXICITY; SAMPLE; SAMPLING; STATISTICAL MODEL; TOXICITY TESTING; WATER SUPPLY;

ANIMALS; COMPUTER SIMULATION; DIBUTYL PHTHALATE; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGEN ANTAGONISTS; ESTROGENS, NON-STEROIDAL; FEMALE; MALE; MODELS, THEORETICAL; ORGAN SIZE; PHENOLS; PREGNANCY; PROSTATE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SAMPLE SIZE; TOXICITY TESTS; WATER SUPPLY;

ANIMALIA;

EID: 0033854361     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0890-6238(00)00092-7     Document Type: Article

References (28)

1. National Research Council Committee on Hormonally Active Agents in the Environment. Hormonally active agents in the environment. Washington, DC: National Academy Press, 1999.
2. Toran-Allerand C.D. Gonadal hormones and brain development implications for the genesis of sexual differentiation . Ann NY Acad Sci. 435:1984;101-111.
3. Gorski R.A. Sexual differentiation of the brain a model for drug-induced alterations of the reproductive system . Environ Health Perspect. 70:1986;163-175.
4. Danzo B.J. The effects of environmental hormones on reproduction. Cell Mol Life Sci. 54:(11):1998;1249-1264.
5. Fenner-Crisp P.A. Endocrine disruptor risk characterization an EPA perspective . Regul Toxicol Pharmacol. 26:1997;70-73.
6. Calabrese E.J., Baldwin L.A., Kostecki P.T., Potter T.L. A toxicologically based weight-of-evidence methodology for the relative ranking of chemicals of endocrine disruption potential. Regul Toxicol Pharmacol. 26:(1 Pt 1):1997;36-40.
7. Ashby J., Elliott B.M. Reproducibility of endocrine disruption data. Regul Toxicol Pharmacol. 26:1997;94-95.
8. Ashby J., Tinwell H., Lefevre P.A., et al. Normal sexual development of rats exposed to butyl benzyl phthalate from conception to weaning. Regul Toxicol Pharmacol. 26:(1):1997;102-118.
9. Nagel S.C., vom Saal F.S., Thayer K.A., Dhar M.G., Boechler M., Welshons W.V. Relative binding affinity-serum modified access (RBA-SMA) assay predicts the relative in vivo bioactivity of the xenoestrogens bisphenol A and octylphenol. Environ Health Perspect. 105:(1):1997;70-76.
10. vom Saal F.S., Cooke P.S., Buchanan D.L., et al. A physiologically based approach to the study of bisphenol A and other estrogenic chemicals on the size of reproductive organs, daily sperm production, and behavior. Toxicol Indust Health. 14:(1/2):1998;239-260.
11. vom Saal F.S., Timms B.G., Montano M.M., et al. Prostate enlargement in mice due to fetal exposure to low doses of estradiol or diethylstilbestrol and opposite effects at high doses. Proc Nat Acad Sci USA. 94:1997;2056-2061.
12. Elswick B.A., Janszen D.B., Gould J.C., Stedman D.B., Welsch F. Effects of perinatal exposure to low doses of bisphenol A in male offspring of Sprague-Dawley rats. Toxicol Sci. 54:(1):2000;256.
13. Mylchreest E, Wallace DG, Cattley RC, Foster PMD. Dose-dependent alterations in androgen-regulated male reproductive development in rats exposed to di-n-butyl phthalate during late gestatation. Toxicol Sci, 2000;55:143-51.
14. Kwon S, Stedman DB, Elswick BA, Cattley RC, Welsch F. Pubertal development and reproductive functions of Crl:CD BR Sprague-Dawley rats exposed to bisphenol A during prenatal and postnatal development. Toxicol Sci, In press.
15. Bosland M.C. Lesions in the male accessory sex glands and in penis. Mohr U., Dungworth D.L., Capen C.C. Pathobiology of the aging rat. Vol. 1:1992;443-467 ILSI Press, Washington, DC.
16. Welshons W.V., Nagel S.C., Thayer K.A., Judy B.M., Vom Saal F.S. Low-dose bioactivity of xenoestrogens in animals fetal exposure to low doses of methoxychlor and other xenoestrogens increases adult prostate size in mice . Toxicol Ind Health. 15:(1-2):1999;12-25.
17. Haseman J.K., Hogan M.D. Selection of the experimental unit in teratology studies. Teratology. 12:(2):1975;165-171.
18. Haseman J.K., Kupper L.L. Analysis of dichotomous response data from certain toxicological experiments. Biometrics. 35:(1):1979;281-293.
19. Williams D.A. The analysis of binary responses from toxicological experiments involving reproduction and teratogenicity. Biometrics. 31:1975;949-952.
20. Rai K., van Ryzin J. A dose-response model for teratological experiments involving quantal responses. Biometrics. 41:(1):1985;1-9.
21. Williams D.A. Dose-response models for teratological experiments. Biometrics. 43:1987;1013-1016.
22. Williams D.A. Estimation bias using the β-binomial distribution in teratology. Biometrics. 44:1988;305-309.
23. Sharpe R.M., Fisher J.S., Millar M.M., Jobling S., Sumpter J.P. Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production. Environ Health Perspect. 103:(12):1995;1136-1143.
24. Sharpe R.M., Turner K.J., Sumpter J.P. Endocrine disruptors and testis development. [letter]. Environ Health Perspect. 106:(5):1998;A220-A221.
25. Ashby J., Tinwell H., Haseman J. Lack of effects for low dose levels of bisphenol A and diethylstilbestrol on the prostate gland of CF1 mice exposed in utero. Regul Toxicol Pharmacol. 30:1999;156-166.
26. Cagen SZ, Waechter JM Jr, Dimond SS, et al. Normal reproductive organ development in CF-1 mice following prenatal exposure to bisphenol A. Toxicol Sci 50:36-44.
27. Palmer A.K., Ulbrich B.C. The cult of culling. Fundam Appl Toxicol. 38:(1):1997;7-22.
28. US. Environmental Protection Agency Office of Prevention, Pesticides and Toxic Substances. Health effects test guidelines, reproduction and fertility effects. Washington, DC; August 1998.