Evaluation of the Tg.AC transgenic mouse assay for testing the human carcinogenic potential of pharmaceuticals - Practical pointers, mechanistic clues, and new questions

International Journal of Toxicology

Volumn 21, Issue 1, 2002, Pages 65-79

  Sistare, Frank D ^a   Thompson, Karol L ^a   Honchel, Ronald ^a   DeGeorge, Joseph ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

Alternative Bioassay; Carcinogens; Skin Carcinogenesis; Tg.AC Transgenic Mouse; Tumor Promotion; v Ha ras Gene

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; ACRYLIC ACID ETHYL ESTER; BENZENE; BENZOYL PEROXIDE; CARCINOGEN; CLOFIBRATE; CYCLOPHOSPHAMIDE; CYCLOSPORIN A; DIETHYLSTILBESTROL; DIMETHYLBENZ[A]ANTHRACENE; ETHINYLESTRADIOL; GLYCIDOL; MELPHALAN; OXYMETHOLONE; PHENACETIN; PIRINIXIC ACID; RESERPINE;

BIOASSAY; CANCER RESEARCH; CARCINOGENICITY; CHEMICAL CARCINOGENESIS; CONFERENCE PAPER; GENOTOXICITY; HUMAN; MOUSE STRAIN; NONHUMAN; ONCOGENE H RAS; SKIN CARCINOGENESIS; STOMACH CARCINOGENESIS; TOXICITY TESTING; TRANSGENIC MOUSE;

ANIMAL TESTING ALTERNATIVES; ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; DISEASE MODELS, ANIMAL; GENES, RAS; GENOTYPE; HUMANS; MICE; MICE, TRANSGENIC; PAPILLOMA; PHARMACEUTICAL PREPARATIONS; SKIN NEOPLASMS;

MUS MUSCULUS;

EID: 0036209865     PISSN: 10915818     EISSN: None     Source Type: Journal    
DOI: 10.1080/10915810252826028     Document Type: Article

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