Tripropylene glycol diacrylate but not ethyl acrylate induces skin tumors in a twenty-week short-term tumorigenesis study in Tg.AC (v-Ha-ras) mice

Toxicologic Pathology

Volumn 26, Issue 4, 1998, Pages 476-483

  Nylander French, Leena A ^a,b   French, John E ^b  

^a University of North Carolina at Chapel Hill   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Carcinogenicity; Dermal; Exposure; Monofunctional acrylates; Multifunctional acrylates; Oncogene; Toxicity; Transgenic mouse

Indexed keywords

ACRYLIC ACID; ACRYLIC ACID ETHYL ESTER; TRIPROPYLENE GLYCOL DIACRYLATE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOASSAY; CARCINOGEN TESTING; CARCINOGENESIS; CONTROLLED STUDY; FEMALE; MOUSE; NONHUMAN; ONCOGENE H RAS; PAPILLOMA; PRIORITY JOURNAL; SKIN TUMOR; TRANSGENIC MOUSE; ULTRAVIOLET RADIATION;

ANIMALIA; MUS MUSCULUS;

EID: 0031824684     PISSN: 01926233     EISSN: None     Source Type: Journal    
DOI: 10.1177/019262339802600403     Document Type: Article

References (36)

1. Allen NS, Johnson MA, Oldring PKT, and Salim MS (1991). Reactive diluents for UV and EB curable formulations. In: Prepolymers and Reactive Diluents for UV and EB Curable Formulations, PKT Oldring (ed). SITA Technology, London, pp. 237-306.
2. American Conference of Governmental Industrial Hygienists (1986). Documentation of the Threshold Limit Values, 5th ed. American Conference of Governmental Industrial Hygienists, Cincinnati, pp. 240-241.
3. Andrews LS and Clary JJ (1986). Review of the toxicity of multifunctional acrylates. J. Toxicol. Environ. Health 19: 149-164.
4. Anonymous (1993). Material Safety Data Sheet; Ethyl Acrylate. Aldrich Chemical Co., Milwaukee, WI.
5. Anonymous (1993). Material Safety Data Sheet; Poly (Propylene Glycol) Diacrylate. Aldrich Chemical Co., Milwaukee, WI.
6. Boyland E and Chasseaud LF (1968). Enzymes catalysing conjugations of glutathione with αβ-unsaturated carbonyl compounds. Biochem. J. 109: 651-661.
7. Corkill JA, Lloyd EJ, Hoyle P, Crout DHG, Ling RSM, James ML, and Piper RJ (1976). Toxicology of methyl methacrylate: The rate of disappearance of methyl methacrylate in human blood in vitro. Clin. Chim. Acta 68: 141-146.
8. deBethizy JD, Udinsky JR, Scribner HE, and Frederick CB (1987). The disposition and metabolism of acrylic acid and ethyl acrylate in male Sprague-Dawley rats. Fundam. Appl. Toxicol. 8: 549-561.
9. Delbressine LPC, Seutter-Berlage F, and Seutter E (1981). Identification of urinary mercapturic acids formed from acrylate, methacrylate and crotonate in the rat. Xenobiotica 11: 241-247.
10. del Rosso Arrighetti VM and Moretti G (1992). Vantaggi e limiti della tecnologia UV. Il punto di vista di un produttore di vernici sul problema della riduzione delle emissione SOV. Verniciatura Legno 11: 12-17.
11. DePass LR, Fowler EH, Meckley DR, and Weil CS (1984). Dermal oncogenecity bioassay of acrylic acid, ethyl acrylate, and butyl acrylate. J. Toxicol. Environ. Health 14: 115-120.
12. DePass LR, Maronpot RR, and Weil CS (1985). Dermal oncogenicity bioassays of monofunctional and multifunctional acrylates and acrylate-based oligomers. J. Toxicol. Environ. Health 16: 55-60.
13. Dufour P (1991). The European market for UV and EB. In: Markets and Curing Equipment, Chemistry & Technology of UV & EB Formulations for Coatings, Inks & Paints, Vol. 1, PKT Oldring (ed). SITA Technology, London, pp. 13-48.
14. Frederick CB, Potter DW, Chang-Mateu MI, and Andersen ME (1992). A physiologically based pharmacokinetic and pharmacodynamic model to describe the oral dosing of rats with ethyl acrylate and its implications for risk assessment. Toxicol. Appl. Pharmacol. 114: 246-260.
15. Ghanayem BI, Burka LT, and Matthews HB (1987). Ethyl acrylate distribution, macromolecular binding, excretion, and metabolism in male Fischer 344 rats. Fundam. Appl. Toxicol. 9: 389-397.
16. Ghanayem BI, Maronpot RR, and Matthews HB (1991). Role of chemically induced cell proliferation in ethyl acrylate-induced forestomach carcinogenesis. In: Chemically Induced Cell Proliferation: Implications for Risk Assessment. Wiley-Liss, New York, pp. 337-346.
17. Hansen LA, Spalding JW, French JE, and Tennant RW (1995). A transgenic mouse model (Tg.AC) for skin carcinogenesis: Inducible transgene expression as a second critical event. In: Growth Factors and Tumor Promotion: Implications for Risk Assessment. Wiley-Liss, New York, pp. 223-235.
18. Hansen L and Tennant RW (1994). Focal transgene expression associated with papilloma development in v-Ha-ras transgenic Tg.AC mice. Mol. Carcinogen. 9: 143-145.
19. Hansen LA and Tennant RW (1994). Follicular origin of epidermal papillomas in v-Ha-ras transgenic Tg.AC mouse skin. Proc. Natl. Acad. Sci. USA 91: 7822-7826.
20. Hansen LA, Trempus CS, Mahler JF, and Tennant RW (1996). Association of tumor development with increased cellular proliferation and transgene overexpression, but not c-Ha-ras mutations, in v-Ha-ras transgenic Tg.AC mice. Carcinogenesis 17: 1825-1833.
21. Holman R and Oldring P (1991). The formulation of radiation curing systems for paints and coating. In: UV & EB Curing Formulation for Printing Inks, Coatings & Paints, 3rd ed. SITA Technology, London, pp. 123-156.
22. Hussain A (1991). Radiation curing: Global trends to year 2000. Adhesion 35: 37.
23. International Agency for Research on Cancer (1986). Some chemicals used in plastics and elastomers. IARC Monogr. Eval. Carcinog. Risk Chem. Hum. 39: 81-98.
24. Lawson RG and Jurs PC (1990). Cluster analysis of acrylates to guide sampling for toxicity testing. J. Chem. Inf. Comput. Sci. 30: 137-144.
25. Leder A, Kuo A, Cardiff RD, Sinn E, and Leder P (1990). v-Ha-ras transgene abrogates the initiation step in mouse skin tumori-genesis: Effects of phorbol esters and retinoic acid. Proc. Natl. Acad. Sci. USA 87: 9178-9182.
26. Miller RR, Ayres JA, Jersey GC, and McKenna MJ (1981). Inhalation toxicity of acrylic acid. Fundam. Appl. Toxicol. 1: 271-277.
27. 1 mice. Drug Chem. Toxicol. 8: 1-42.
28. 1 Mice (Gavage Studies). Technical Report Series No. 259, U.S. Department of Health and Human Services, Public Health Service, National Institutes of Health, Research Triangle Park, North Carolina.
29. Nylander-French LA, Fischer T, Hultengren M, Lewné M, and Rosén G (1994). Assessment of worker exposure in the processing of ultraviolet radiation cured acrylate lacquer coated wood products. Appl. Occup. Environ. Hyg. 9: 962-976.
30. Pozzani UC, Weil CS, and Carpenter CC (1949). Subacute vapor toxicity and range-finding data for ethyl acrylate. J. Ind. Hyg. Toxicol. 31: 311-316.
31. Sax NI and Lewis RJ (1989). Dangerous Properties of Industrial Chemicals. Van Nostrand Reinhold, New York.
32. Silver EH and Murphy SD (1981). Potentiation of acrylate ester toxicity by prior treatment with the carboxylesterase inhibitor triorthotolyl phosphate (TOTP). Toxicol. Appl. Pharmacol. 57: 208-219.
33. Spalding JW, Momma J, Elwell MR, and Tennant RW (1993). Chemically induced skin carcinogenesis in a transgenic mouse line (TG·AC) carrying a v-HA-ras gene. Carcinogenesis 14: 1335-1341.
34. Tennant RW, French JE, and Spalding JW (1995). Identification of chemical carcinogens and assessing potential risk in short term bioassays using transgenic mouse models. Environ. Health Perspect. 103: 942-950.
35. Tennant RW, Spalding J, and French JE (1996). Evaluation of transgenic mouse bioassays for identifying carcinogens and noncarcinogens. Mutat. Res. 365: 119-127.
36. Wenzel-Hartung RP, Brune H, and Klimisch HJ (1989). Dermal oncogenicity study of 2-ethylhexyl acrylate by epicutaneous application in male C3H/HeJ mice. J. Cancer Res. Clin. Oncol. 115: 543-549.