Instability of long inverted repeats within mouse transgenes

EMBO Journal

Volumn 15, Issue 5, 1996, Pages 1163-1171

  Collick, Andrew ^a   Drew, Jane ^a   Penberth, Jessica ^b   Bois, Philippe ^a   Luckett, Jeni ^a   Scaerou, Frederic ^a   Jeffreys, Alec ^a   Reik, Wolf ^b  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

^b BABRAHAM INSTITUTE   (United Kingdom)

Author keywords

Instability; Inverted repeat; Mouse; Transgene

Indexed keywords

DNA MINISATELLITE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; GENE DELETION; GENE FREQUENCY; GENE INSERTION; GENE MUTATION; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC ANALYSIS; GENETIC STABILITY; INBRED STRAIN; LONG INVERTED REPEAT; MITOSIS RATE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; TRANSGENE;

ANIMALIA; MAMMALIA;

EID: 0029871490     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00455.x     Document Type: Article

References (31)

1. Allen, M.J., Jeffreys, A.J., Surani, M A., Barton, S.C., Norris, M L. and Collick, A (1994) Tandemly repeated transgenes of the human minisatellite MS32 (D1S8) with novel gamma satellite integration. Nucleic Acids Res., 22, 2976-2981.
2. Bennett, R.J., Dunderdale, H.J. and West, S.C. (1993) Resolution of Holliday junctions by RuvC resolvase-cleavage and DNA distortion. Cell, 74, 1021-1031.
3. Biessmann, H. and Mason, J.M. (1992) Genetics and molecular biology of telomeres. Adv. Genet., 30, 185-249.
4. Bronner, C.E. et al. (1994) Mutation in the DNA mismatch repair gene homolog HLMH1 is associated with hereditary nonpolyosis colon cancer. Nature, 368, 258-261.
5. Cheng, S. and Schildkraut, C.L. (1980) A family of moderately repetitive sequences in the mouse genome. Nucleic Acids Res., 8, 4075-4090.
6. Collick, A., Norris, M.L., Allen, M.J., Bois, P., Barton, S.C., Surani, M.A. and Jeffreys, A.J (1994) Variable germline and embryonic instability of the human minisatellite MS32 (D1S8) in transgenic mice. EMBO J., 13, 5745-5753.
7. de Graaff, E., Rouillard, P., Willems, P.J., Smits, A.P.T., Rousseau, F. and Oostra, B.A. (1995) Hotspot for deletions in the CGG repeat region of FMR1 in fragile X patients Human Mol. Genet., 4, 45-49.
8. Fishel, R. et al. (1993) The human mutator gene homolog MSH2 and its association with hereditary non-polypopsis colon cancer. Cell, 75, 1027-1038.
9. Freid, M., Feo, S. and Heard, E. (1991) The role of inverted duplication in the generation of gene amplification in mammalian cells. Biochemistry B Acta, 1090, 143-155.
10. Gordenin, D.A., Lobachev, K.S., Degtyareva, N P., Malkova, A.L., Perkins, E. and Resnick, M.A. (1993) Inverted repeats as a source of eukaryotic DNA instability. Mol. Cell. Biol., 13, 5315-5322.
11. Henderson, S T. and Petes, T.D. (1993) Instability of plasmid-borne inverted repeats in Saccharomyces cerevisiae. Genetics, 113, 57-62.
12. Holliday, R (1964) A mechanism for gene conversion in fungi Genet. Res., 5, 282-304.
13. Horz, W. and Altenburger, W. (1981) Nucleotide sequence of mouse satellite DNA. Nucleic Acids Res., 9, 2989-2998
14. Jeffreys, A.J., Tamaki, K., Macleod, A., Monckton, D.G., Neil, D L and Armour, J.A.L. (1994) Complex gene conversion events in germline mutation at human minisatellites. Nature Genet., 6, 136-145
15. Leach, D.R.F. (1994) Long DNA palindromes, cruciform structures. genetic instability and secondary structure repair. BioEssays, 16, 893-900.
16. Leach, D.R F., Lloyd, R.G. and Coulson, A.F.C. (1992) The SbcCD protein of E.coli is related to 2 putative nucleases in the UvrA superfamily of nucleotide binding proteins. Generica, 87, 95-100.
17. Leach, F.S. et al. (1993) Mutations of a mutS homolog in heriditary non-polyposis colerectal cancer. Cell, 75, 1215-1225.
18. Lloyd, R.G. and Buckman, C. (1985) Identification of SbcC mutations in commonly used RecBC SbcC strains of E.coli K12 J. Bacteriology, 164, 836-844.
19. McLaren, A. (1991) Development of the mammalian gonad: the fate of the supporting cell lineage. BioEssays, 13, 151-156.
20. Morris, T. and Thacker, J. (1993) Formation of large deletions by illegitimate recombination in the HPRT gene of primiary human fibroblasts. Proc. Natl Acad. Sci. USA, 90, 1392-1396.
21. Nalbantoglu, J., Hartley, D , Phear, G., Tear, G and Meuth, M. (1986) Spontaneous deletion formation at the APRT locus of hamster cells - the presence of short sequence homologies and dyad symmetries at deletion termini. EMBO J., 5, 1199-1204.
22. Palmiter, R.D and Brinster, R.L. (1986) Germhne tranformation of mice. Annu. Rev. Genet., 20, 465-499.
23. Papadopolous, N. et al. (1994) Mutation in a MutL homolog in a heriditary colon cancer. Science, 263, 1625-1629.
24. Pearson, C.E., Ruiz, M.T., Price, G.B. and Zannis-Hadjopolous, M. (1994) Cruciform DNA-binding protein in HeLa cell extraction. Biochemistry, 33, 14185-14196.
25. Reik, W., Howlett, S.K. and Surani, M.A. (1990) Imprinting by DNA methylation from transgene to endogenous gene sequences. Development, 8, 99-106.
26. Ruskin, B. and Fink, G.R. (1993) Mutations in POL1 increase the mitotic instability of tandem inverted repeats in Saccharomyces cerevisiae. Genetics, 133, 43-56.
27. Sandgren, E.P., Palmiter, R.D., Heckel, J.L., Brinster, R.L. and Degen, J.L. (1992) DNA rearrangements cause hepatocarcinogenesis in albumin plasminogen-activator transgenic mice. Proc. Natl Acad. Sci. USA, 89, 11523-11527.
28. Sharples, G.J., Chan, S.N., Mahdi, A.A., Whitby, M.C. and Lloyd, R.G. (1994) Processing of intermediates in recombination and DNA repair - identification of a new endonuclease that specifically cleaves Holliday junctions. EMBO J., 13, 6133-6142.
29. Sharpe, M J., Neuberger, M., Pannell, R., Surani, M.A. and Milstein, C. (1990) Lack of somatic mutation in a chi-light chain transgene Eur. J. Immunol., 20, 1379-1385.
30. Stark, G.R., Debatisse, M., Giulotto, E. and Wahl, G.M. (1989) Recent progress in the understanding of mechanisms of mammalian DNA amplification. Cell, 57, 901-908.
31. Watson, J. and Crick, F.H.C. (1953) A structure for deoxyribose nucleic acids. Nature, 171, 737-738.