Transduction of hepatocytes after neonatal delivery of a moloney murine leukemia virus based retroviral vector results in long-term expression of β-glucuronidase in mucopolysaccharidosis VII dogs

Molecular Therapy

Volumn 5, Issue 2, 2002, Pages 141-153

  Xu, Lingfei ^a   Haskins, Mark E ^b   Melniczek, John R ^b   Gao, Cuihua ^a   Weil, Margaret A ^b   O'Malley, Thomas M ^b   O'Donnell, Patricia A ^b   Mazrier, Hamutal ^b   Ellinwood, N Matthew ^b   Zweigle, Jean ^b   Wolfe, John H ^b,c   Ponder, Katherine Parker ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

Bromodeoxyuridine; Dog; Gene therapy; Labeling index; Lysosomal storage disease; Mucopolysaccharidosis; Retroviral vector; glucuronidase

Indexed keywords

BETA GLUCURONIDASE; COMPLEMENTARY DNA; RETROVIRUS VECTOR; SCATTER FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIVISION; CELL GROWTH; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DOG; DRUG BLOOD LEVEL; GENETIC DISORDER; GENETIC TRANSDUCTION; HOMOZYGOSITY; IN VIVO STUDY; LETHALITY; LIVER CELL; MOLONEY LEUKEMIA ONCOVIRUS; MUCOPOLYSACCHARIDOSIS TYPE 7; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SPLEEN CELL; VIRAL GENE DELIVERY SYSTEM;

ANIMALIA; CANIS FAMILIARIS; MOLONEY MURINE LEUKEMIA VIRUS; MURINAE; MURINE LEUKEMIA VIRUS; ONCOVIRINAE; UNIDENTIFIED RETROVIRUS;

EID: 0036168867     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1006/mthe.2002.0527     Document Type: Article

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