Retrovirus-mediated in vivo gene transfer in the replicating liver using recombinant hepatocyte growth factor without liver injury or partial hepatectomy

Human Gene Therapy

Volumn 9, Issue 9, 1998, Pages 1293-1301

  Kosai, Ken Ichiro ^a,c   Finegold, Milton J ^a   Thi Huynh, Bich Thuy ^a   Tewson, Margaret ^a   Ching Nan, O U ^a   Bowles, Neil ^a   Woo, Savio L C ^a   Schwall, Ralph H ^b   Darlington, Gretchen J ^a,d  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b GENENTECH INC   (United States)

^c KURUME UNIVERSITY   (Japan)

^d TEXAS CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RECOMBINANT SCATTER FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; EXPRESSION VECTOR; GENE EXPRESSION; GENE TARGETING; GENE TRANSFER; GENETIC TRANSDUCTION; LIVER INJURY; MALE; NONHUMAN; PARTIAL HEPATECTOMY; RAT; RETROVIRUS;

ANIMALIA; UNIDENTIFIED RETROVIRUS;

EID: 0032503632     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/hum.1998.9.9-1293     Document Type: Article

References (13)

1. ARBER, N., ZAJICEK, G., and ARIEL, I. (1988). The streaming liver. II. Hepatocyte life history. Liver 8, 80-87.
2. BOSCH, A., MCCRAY, P.B. JR., CHANG, S.M., ULICH, T.R., SIMONET, W.S., JOLLY, D.J., and DAVIDSON, B.L. (1996). Proliferation induced by keratinocyte growth factor enhances in vivo retroviral-mediated gene transfer to mouse hepatocytes. J. Clin. Invest. 98, 2683-2687.
3. BRANCHEREAU, S., CALISE, D., and FERRY, N. (1994). Factors influencing retroviral-mediated gene transfer into hepatocytes in vivo. Hum. Gene Ther. 5, 803-808.
4. BRUSILOW, S.W., and HORWICH, A.L. (1995). Urea cycle enzymes. In The Metabolic and Molecular Bases of Inherited Disease. C.R. Scriver, A.L. Beaudet, W.S. Sly, and D. Valle, eds. (McGraw-Hill, Inc., New York) vol. 7, pp. 1187-1232.
5. FANG, B., WANG, H., GORDON, G., BELLINGER, D.A., READ, M.S., BRINKHOUS, K.M., WOO, S.L., and EISENSMITH, R.C. (1996). Lack of persistence of E1-recombinant adenoviral vectors containing a temperature-sensitive E2A mutation in immunocompetent mice and hemophilia B dogs. Gene Ther. 3, 217-222.
6. FUJIWARA, K., NAGOSHI, S., OHNO, A., HIRATA, K., OHTA, Y., MOCHIDA, S., TOMIYA, T., HIGASHIO, K., and KUROKAWA, K. (1993). Stimulation of liver growth by exogenous human hepatocyte growth factor in normal and partially hepatectomized rats. Hepatology 18, 1443-1449.
7. GUNZBURG, W.H., and SALMONS, B. (1996). Development of retroviral vectors as safe, targeted gene delivery systems. J. Mol. Med. 74, 171-182.
8. HAJIHOSSEINI, M., IAVACHEV, L., and PRICE, J. (1993). Evidence that retroviruses integrate into post-replication host DNA. EMBO J. 12, 4969-4974.
9. HIGGINS, G., and ANDERSON, R. (1931). Experimental pathology of the liver I. Restoration of the liver of the white rat following partial surgical removal. Arch. Pathol. 12, 186-202.
10. ISHII, T., SATO, M., SUDO, K., SUZUKI, M., NAKAI, H., HISHIDA, T., NIWA, T., UMEZU, K., and YUASA, S. (1995). Hepatocyte growth factor stimulates liver regeneration and elevates blood protein level in normal and partially hepatectomized rats. J. Biochem. (Tokyo) 117, 1105-1112.
11. WEBBER, E.M., GODOWSKI, P.J., and FAUSTO, N. (1994). In vivo response of hepatocytes to growth factors requires an initial priming stimulus. Hepatology 19, 489-497.
12. YANG, Y., NUNES, F.A., BERENCSI, K., FURTH, E.E., GONCZOL, E., and WILSON, J.M. (1994). Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. Proc. Natl. Acad. Sci. USA 91, 4407-4411.
13. YEE, J.K., FRIEDMANN, T., and BURNS, J.C. (1994). Generation of high-titer pseudo typed retroviral vectors with very broad host range. Methods Cell Biol. 43, 99-112.