TNF-α-induced tolerance to ischemic injury involves differential control of NF-κB transactivation: The role of NF-κB association with p300 adaptor

Journal of Cerebral Blood Flow and Metabolism

Volumn 22, Issue 2, 2002, Pages 142-152

  Ginis, Irene ^a   Jaiswal, Rama ^a   Klimanis, Dace ^a   Liu, Jie ^a   Greenspon, Jose ^a   Hallenbeck, John M ^a  

^a NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Astrocytes; NF B; p300 adapter protein; Protein kinase A; Stress adaptation; Tolerance; Tumor necrosis factor

Indexed keywords

ADAPTOR PROTEIN; CERAMIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; MANGANESE SUPEROXIDE DISMUTASE; PROTEIN P300; SPHINGOLIPID; SYNAPTOTAGMIN; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN INJURY; BRAIN ISCHEMIA; CELL PROTECTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE REPRESSION; GENETIC TRANSCRIPTION; INFLAMMATION; NERVE CELL CULTURE; NEWBORN; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; STRESS;

EID: 0036167642     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004647-200202000-00002     Document Type: Article

References (67)

1. Monocyte: Astrocyte interactions regulate MCP-1 expression in both cell types
2. Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells
3. Brain injury and inflammation. A putative role of TNF alpha
4. IkappaB-NF-kappaB structures: At the interface of inflammation control
5. Activate NF-kappa B or die?
6. Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: Evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation
7. Inflammatory mediators and stroke: New opportunities for novel therapeutics
8. Activation of nuclear transcription factor NF-kappaB by interleukin-1 is accompanied by casein kinase II-mediated phosphorylation of the p65 subunit
9. NF kappa B-independent transcriptional induction of the human manganous superoxide dismutase gene
10. Loss of NF-kappaB activity during cerebral ischemia and TNF cytotoxicity
11. Ischemic tolerance in brain
12. The protective effects of ceramide in immature rat brain hypoxia-ischemia involve upregulation of bcl-2 and inhibition of apoptosis
13. Protein kinase Cdelta-dependent induction of manganese superoxide dismutase gene expression by microtubule-active anticancer drugs
14. Inhibition of tumor necrosis factor-alpha reduces focal cerebral ischemic injury in the spontaneously hypertensive rat
15. Inflammation and stroke: Putative role for cytokines, adhesion molecules and iNOS in brain response to ischemia
16. Evidence for the in vitro and in vivo interaction of Ras with protein kinase C zeta
17. Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia
18. Ceramide-induced translocation of protein kinase C zeta in primary cultures of astrocytes
19. CREB-binding protein/p300 are transcriptional coactivators of p65
20. Protection from apoptosis in human neutrophils is determined by the surface of adhesion
21. TNFα pretreatment prevents subsequent activation of cultured brain cells with TNFα and hypoxia via Ceramide
22. Tumor necrosis factor reactive oxygen species cooperative cytotoxicity is mediated via inhibition of NF-κB
23. Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning
24. Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid beta-peptide toxicity
25. A novel pathway for tumor necrosis factor-alpha and ceramide signaling involving sequential activation of tyrosine kinase, p21(ras), and phosphatidylinositol 3-kinase
26. Adhesion to human neurons and astrocytes of monocytes: The role of interaction of CR3 and ICAM-1 and modulation by cytokines
27. Multiple mRNA species generated by alternate polyadenylation from the rat manganese superoxide dismutase gene
28. Tumor necrosis factor alpha and interleukin-1beta regulate the murine manganese superoxide dismutase gene through a complex intronic enhancer involving C/EBP-beta NF-kappaB
29. Mitochondrial manganese superoxide dismutase prevents neural apoptosis and reduces ischemic brain injury: Suppression of peroxynitrite production, lipid peroxidation, and mitochondrial dysfunction
30. Transcriptional activation of the human manganese superoxide dismutase gene mediated by tetradecanoylphorbol acetate
31. TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury
32. ICAM-1-induced expression of proinflammatory cytokines in astrocytes: Involvement of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways
33. Transcriptional regulation of intercellular adhesion molecule-1 in astrocytes involves NF-kappaB and C/EBP isoforms
34. Renaturation and tumor necrosis factor-alpha stimulation of a 97-kDa ceramide-activated protein kinase
35. Hypoxic preconditioning protects cultured neurons against hypoxic stress via TNF-α and ceramide
36. Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase
37. Apoptotic and antiapoptotic mechanisms in stroke
38. Roles of nuclear factor kappaB in neuronal survival and plasticity
39. Sphingolipids-the enigmatic lipid class: Biochemistry, physiology, and pathophysiology
40. PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid
41. Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling
42. TNF-alpha pre-treatment induces protective effects against focal cerebral ischemia in mice
43. The stress response and the hypothalamic-pituitary-adrenal axis: From molecule to melancholia
44. Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide
45. The Rel/NF-kappa B family: Friend and foe
46. Regulation of NF-kappaB by cyclin-dependent kinases associated with the p300 coactivator
47. Structural and functional analysis of the NF-kappa B p65 C terminus. An acidic and modular transactivation domain with the potential to adopt an alpha-helical conformation
48. NF-kappaB is activated and promotes cell death in focal cerebral ischemia
49. Nuclear integration of glucocorticoid receptor and nuclear factor-kappaB signaling by CREB-binding protein and steroid receptor coactivator-1
50. Intercellular adhesion molecule-1 expression on glia following brain injury: Participation of interleukin-1 beta
51. Dual role of tumor necrosis factor alpha in brain injury
52. Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit
53. Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury
54. Central nervous system DNA fragmentation induced by the inhibition of nuclear factor kappa B
55. Lipopolysaccharide pre-treatment induces resistance against subsequent focal cerebral ischemic damage in spontaneously hypertensive rats
56. Activation of NF-kappaB induced by H(2)O(2) and TNF-alpha and its effects on ICAM-1 expression in endothelial cells
57. p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways are required for nuclear factor-kappaB p65 transactivation mediated by tumor necrosis factor
58. The nuclear factor-kappaB engages CBP/p300 and histone acetyltransferase activity for transcriptional activation of the interleukin-6 gene promoter
59. Activation of nuclear factor-kappaB-dependent transcription by tumor necrosis factor-alpha is mediated through phosphorylation of RelA/p65 on serine 529
60. Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-kappaB/JNK kinase and cell survival
61. Role of ceramide-activated protein phosphatase in ceramide-mediated signal transduction
62. Increased cortical nuclear factor-kappa B (NF-kappa B) DNA binding activity after traumatic brain injury in rats
63. Protein-tyrosine kinase activation is required for lipopolysaccharide induction of interleukin 1beta and NFkappaB activation, but not NFkappaB nuclear translocation
64. Kinase suppressor of Ras is ceramide-activated protein kinase
65. The transcriptional activity of NF-kappaB is regulated by the IkappaB-associated PKAc subunit through a cyclic AMP-independent mechanism
66. Phosphorylation of NF-kappa B p65 by PKA stimulates transcriptional activity by promoting a novel bivalent interaction with the coactivator CBP/p300
67. Lipopolysaccharide-induced ischemic tolerance is associated with increased levels of ceramide in brain and in plasma