Defective lipopolysaccharide-dependent ERK 1/2 activation in endotoxin tolerant murine macrophages is reversed by direct protein kinase C stimulation

Shock

Volumn 14, Issue 2, 2000, Pages 169-175

  West, Michael A ^a   Clair, Laurel ^b   Bellingham, Janet ^b   Wahlstrom, Kyle ^b   Rodriguez, Jorge L ^b  

^a HENNEPIN COUNTY MEDICAL CENTER   (United States)

^b NONE

Author keywords

Cytokines; Endotoxin shock; Rodent; Sepsis; Signal transduction

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; BISINDOLYLMALEIMIDE; ENZYME INHIBITOR; FLAVONOID; INDOLACTAM V; INDOLE DERIVATIVE; LACTAM; LIPOPOLYSACCHARIDE; MALEIMIDE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BIOSYNTHESIS; DRUG EFFECT; DRUG TOLERANCE; ENZYME ACTIVATION; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; MALE; METABOLISM; MOUSE; PERITONEUM MACROPHAGE; PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; ANIMALS; DRUG TOLERANCE; ENZYME ACTIVATION; ENZYME INHIBITORS; FLAVONOIDS; GENE EXPRESSION REGULATION; INDOLES; LACTAMS; LIPOPOLYSACCHARIDES; MACROPHAGES, PERITONEAL; MALE; MALEIMIDES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, INBRED BALB C; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN PROCESSING, POST-TRANSLATIONAL; TETRADECANOYLPHORBOL ACETATE; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034242965     PISSN: 10732322     EISSN: None     Source Type: Journal    
DOI: 10.1097/00024382-200014020-00016     Document Type: Article

References (40)

1. Johnston CA, Greisman SE: Mechanisms of endotoxin tolerance. In Proctor RA, Hinshaw LB (eds): Pathophysiology of Endotoxin. Amsterdam: Elsevier Science, 1985, 2:359-401.
2. Shinji H, Akagawa K, Yoshida T: LPS induces selective translocation of protein kinase C-β in LPS-responsive mouse macrophages, but not in LPS-nonresponsive mouse macrophages. J Immunol 153:5760-5771, 1994.
3. Takasuka N, Tokunaga T, Akagawa KS: Preexposure of macrophages to low doses of lipopolysaccharide inhibits the expression of tumor necrosis factor-α mRNA but not of IL-1β mRNA. J Immunol 146:3824-3830, 1991.
4. Hirohashi N, Morrison DC: Low-dose lipopolysaccharide (LPS) pretreatment of mouse macrophages modulates LPS-dependent interleukin-6 production in vitro. Infect Immun 64:1011-1015, 1996.
5. 2, nitric oxide and superoxide by macrophages. J Trauma 37:82-90, 1994.
6. Li MH, Seatter SC, Manthei R, Bubrick MP, West MA: Macrophage endotoxin tolerance: effect of TNF or endotoxin pretreatment. J Surg Res 57:85-92, 1994.
7. Coffee KA, Halushka PV, Ashton SH, Tempel GE, Wise WC, Cook JA: Endotoxin tolerance is associated with altered GTP-binding protein function. Am J Physiol 73:1008-1013, 1992.
8. Mathison J, Wolfson E, Steinemann S, Ulevitch R: Lipopolysaccharide (LPS) recognition in macrophages: participation of LPS-binding protein and CD14 in LPS-induced adaptation in rabbit peritoneal exudate macrophages. J Clin Invest 92:2053-2059, 1993.
9. Cavaillon JM, Pitton C, Fitting C: Endotoxin tolerance is not a LPS-specific phenomenon: partial mimicry with IL-1, IL-10 and TGFβ. J Endotoxin Res 1:21-29, 1994.
10. West MA, Bennett T, Seatter SC, Clair L, Bellingham J: LPS pretreatment reprograms macrophage LPS-stimulated TNF and IL-1 release without protein tyrosine kinase activation. J Leukoc Biol 61:88-95, 1997.
11. Kastenbauer S, Zeigler-Heitbrock HWL: NF-kB1 (p50) is upregulated in lipopolysacchride tolerance and can block tumor neecrosis factor gene expression. Infect Immun 67:1553-1559, 1999.
12. Chen TY, Lei MG, Suzuki T, Morrison DC: Lipopolysaccharide receptors and signal transduction in mononuclear phagocytes. Curr Top Microbiol Immunol 181:169-188, 1992.
13. Sweet MJ, Hume DA: Endotoxin signal transduction in macrophages. J Leukoc Biol 60:8-26, 1996.
14. West MA, LeMieur T, Clair L, Bellingham J, Rodriguez JL: Protein kinase C regulates macrophage tumor necrosis factor secretion: direct protein kinase C activation restores tumor necrosis factor production in endotoxin tolerance. Surgery 122:204-212, 1997.
15. Aggarwal BB: Human lymphotoxin. Methods Enzymol 116:441-448, 1985.
16. Toullec D, Pianetti P, Coste H, Bellevergue P, Grand-Perret T, Ajankane M, Baudet V, Boisson P, Boursier E, Duhamel L, Charon D, Kirilovsky J: The bisondolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C. J Biol Chem 266:15771-15781, 1991.
17. Heikkilia J, Akerman KE: (-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor function in SH-SY5Y human neuroblastoma cells. Biochem Biophys Res Commun 162:1207-1213, 1989.
18. Fujihara M, Connolly N, Ito N, Suzuki T: Properties of protein kinase C isoforms (βII, ε, and ζ) in a macrophage cell line (J774) and their roles in LPS-induced nitric oxide production. J Biol Chem 152:1898-1906, 1994.
19. Weinstein SL, Sanghera JS, Lemke K, DeFranco AL, Pelech SL: Bacterial lipopolysaccharide induces tyrosine phosphorylation and activation of mitogen-activated protein kinases in macrophages. J Biol Chem 267: 14955-14962, 1992.
20. Chomcyznski P, Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanat-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
21. Seatter SC, Bergren T, Li MH, Bubrick MP, West MA: Macrophage endotoxin tolerance: tumor necrosis factor and interleukin-1 regulation by lipopolysaccharide pretreatment. Arch Surg 129:1263-1270, 1994.
22. Seatter SC, Clair L, Bennett T, Bubrick MP, West MA: Independent signal transduction pathways for IL-1and TNF in LPS-tolerant macrophages. J Surg Res 58:651-658, 1995.
23. Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR: PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270:27489-27494, 1995.
24. Hambleton J, McMahon M, DeFranco AL: Activation of Raf-1 and mitogen-activated protein kinase in murine macrophages partially mimics lipopolysaccharide-induced signaling events. J Exp Med 182:147-154, 1995.
25. Perea P-Y, Vogel SN, Detore GR, Haziot A, Goyert SM: CD14-dependent and CD14-independent signaling pathways in murine macrophages from normal and CD 14 knockout mice stimulated with lipopolysaccharide or taxol. J Immunol 158:4422-4429, 1997.
26. Chow JC, Young DW, Golenbock DT, Christi WJ, Gusovsky F: Toll-like receptor-4 mediates lipopolysaccharide-induced signal trasnduction. J Biol Chem 274:10689-10692, 1999.
27. Hoshino K, Takeuchi O, Kawai T, Sanjo H, Ogawa T, Takeda Y, Takeda K, Akira S: Toll-like receptor 4 (TLR4)-deficient mice are hyporesonsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product. J Immunol 162:3749-3752, 1999.
28. Lynn WA, Liu Y, Golenbock DT: Neither CD14 nor serum is absolutely necessary for activation of mononuclear phagocytes by bacterial lipopolysaccharide. Infect Immmun 61:4452-4461, 1993.
29. Reimann T, Büscher D, Hipskind RA, Krautwald S, Lohmann-Mathes M-L, Baccarini M: Lipopolysaccharide induces activation of the Raf-1/ MAP kinase pathway: a putative role for Raf-1 in the induction of the IL-1β and the TNF-α genes. J Immunol 153:5740-5749, 1994.
30. Han J, Brown T, Beutler B: Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. J Exp Med 171:465-475, 1990.
31. West MA, Baker J, Bellingham J, Clair L: Discordant reprogramming of LPS-stimulated cytokine gene transcription and secretion by macrophages after LPS pretreatment. J Surg Res 63:209-214, 1996.
32. Lieberman AP, Pitha PM, Shin ML: Poly (A) removal is the kinase regulated step in tumor necrosis factor mRNA decay. J Biol Chem 267:2123-2126, 1992.
33. Shapira L, Takashiba S, Champagne C, Amar S, Van Dyke TE: Involvement of protein kinase C and protein tyrosine kinase in lipopolysacchride-induced TNFα and IL-1β production by human monocytes. J Immunol 153:1818-1824, 1994.
34. Liu MK, Herrera-Velit P, Browney RW, Reiner NE: CD14-dependent activation of protein kinase C and mitogen-activated kinases (p42 and p44) in human monocytes treated with bacterial lipopolysaccharide. J Immunol 153:2642-2652, 1994.
35. Chung IY, Kwon J, Benveniste EN: Role of protein kinase C activity in tumor necrosis factor-α gene expression. J Immunol 149:389-3902, 1992.
36. Bakouche O, Moreau JL, Lachman LB: Secretion of IL-1: Role of protein kinase C. 148:84-91, 1992.
37. Herrera-Velit P, Knutson KL, Reiner NE: Phosphatidylinositol 3-kinase-dependent activation of protein kinase C-&zgr; in bacterial lipopolysaccharide-treated human monocytes. J Immunol 272:16445-16452, 1997.
38. Kraatz J, Clair L, Rodriguez JL, West MA: Macrophage endotoxin signal transduction in sepsis: Endotoxin pretreatment upregulates nuclear factor κ-B and inhibits mitogen activated protein kinase. Surg Forum 48:53-55, 1997.
39. Kraatz J, Bellingham J, Wahlstrom KL, Rodriguez JL, West MA: In vitro macrophage endotoxin (LPS) tolerance: defective MAP kinase signal transduction after in vitro LPS pretreatment is not present in macrophages from C3H/HeJ endotoxin tolerant mice. Shock 11:60-65, 1999.
40. Manthey CL, Wang S-W, Kinney SD, Yao Z: SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes. J Leukoc Biol 64:409-417, 1998.