Sustained endotoxemia leads to marked down-regulation of early steps in the insulin-signaling cascade

Critical Care Medicine

Volumn 29, Issue 4, 2001, Pages 839-846

  McCowen, Karen C ^a,b   Ling, Pei Ra ^b   Ciccarone, Annamaria ^a   Mao, Yilei ^a   Chow, Jesse C ^a   Bistrian, Bruce R ^b   Smith, Robert J ^a,b,c  

^a JOSLIN DIABETES CENTER   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c RHODE ISLAND HOSPITAL   (United States)

Author keywords

Catabolic stress; Endotoxin; Endotoxin tolerance; Insulin receptor; Insulin receptor substrate proteins; Insulin resistance; Insulin signaling; Malnutrition; Phosphatidylinositide 3 kinase; Tyrosine phosphorylation

Indexed keywords

ENDOTOXIN; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P85;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENDOTOXEMIA; INSULIN RESISTANCE; LIVER; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

EID: 0035049275     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/00003246-200104000-00032     Document Type: Article

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