Presynaptic calcium current modulation by a metabotropic glutamate receptor

Science

Volumn 274, Issue 5287, 1996, Pages 594-597

  Takahashi, Tomoyuki ^a   Forsythe, Lan D ^b   Tsujimoto, Tetsuhiro ^a   Barnes Davies, Margaret ^b   Onodera, Kayoko ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 AMINO 1,3 CYCLOPENTANEDICARBOXYLIC ACID; 2 AMINO 4 PHOSPHONOBUTYRIC ACID; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM ION; GLUTAMATE RECEPTOR AGONIST; GLYCINE DERIVATIVE; METABOTROPIC RECEPTOR; NIFEDIPINE; NIMODIPINE; OMEGA AGATOXIN IVA; RECEPTOR SUBTYPE; TETRODOTOXIN;

ANIMAL TISSUE; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN SLICE; BRAIN STEM; CALCIUM CONDUCTANCE; CALCIUM CURRENT; CONTROLLED STUDY; EXCITATORY POSTSYNAPTIC POTENTIAL; MEMBRANE POTENTIAL; NEUROTRANSMITTER RELEASE; NONHUMAN; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; RAT;

AMINOBUTYRIC ACIDS; ANIMALS; BRAIN STEM; CADMIUM; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; EXCITATORY AMINO ACID AGONISTS; NEUROTRANSMITTER AGENTS; PATCH-CLAMP TECHNIQUES; POTASSIUM; POTASSIUM CHANNELS; PRESYNAPTIC TERMINALS; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; SYNAPSES; SYNAPTIC TRANSMISSION;

ANIMALIA; CALYX; IVA; MAMMALIA;

EID: 0029845117     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.274.5287.594     Document Type: Article

References (41)

1. S. Nakanishi, Neuron 13,1031 (1994); D. D. Schoepp and P. J. Conn, Trends Pharmacol. Sci. 14, 13 (1993).
2. S. Nakanishi, Neuron 13,1031 (1994); D. D. Schoepp and P. J. Conn, Trends Pharmacol. Sci. 14, 13 (1993).
3. I. D. Forsythe and J. D. Clements, J. Physiol. (London) 429, 1 (1990); A. Baskys and R. C. Malenka, ibid. 444, 687 (1991).
4. I. D. Forsythe and J. D. Clements, J. Physiol. (London) 429, 1 (1990); A. Baskys and R. C. Malenka, ibid. 444, 687 (1991).
5. Y. Hayashi et al., Nature 366, 687 (1993).
6. F. Sladeczek, A. Momiyama, T. Takahashi, Proc. R Soc. London Ser B 253, 297 (1993).
7. K. Kobayashi, T. Manabe, T, Takahashi, Science 273, 648 (1996); M. Yokoi et al., ibid., p. 645.
8. K. Kobayashi, T. Manabe, T, Takahashi, Science 273, 648 (1996); M. Yokoi et al., ibid., p. 645.
9. T. Takahashi, A. Momiyama, S. G. Cull-Candy, J. Physiol. (London) 446, 549P (1992).
10. K. J. Swartz and B. P. Bean, J. Neurosci. 12, 4358 (1992); Y. Sahara and G. L. Westbrook, ibid. 13. 3041 (1993).
11. K. J. Swartz and B. P. Bean, J. Neurosci. 12, 4358 (1992); Y. Sahara and G. L. Westbrook, ibid. 13. 3041 (1993).
12. D. M. Lovinger, E. Tyler, S. Fidler, A. Merritt, J. Neurophysiol. 69, 1236 (1993).
13. M. Yoshino and H. Kamiya, Brain Res. 695, 179 (1995).
14. M. Barnes-Davies and I. D. Forsythe, J. Physiol. (London) 488, 387 (1995).
15. J.-C. Poncer, H. Shinozaki, R. Miles, ibid. 485, 121 (1995); I. Llano and A. Marty, ibid. 486, 163 (1995).
16. J.-C. Poncer, H. Shinozaki, R. Miles, ibid. 485, 121 (1995); I. Llano and A. Marty, ibid. 486, 163 (1995).
17. B. Katz and R. Miledi, ibid 192, 407 (1967); N. Kawai and A. Niwa, ibid. 305, 73 (1980).
18. B. Katz and R. Miledi, ibid 192, 407 (1967); N. Kawai and A. Niwa, ibid. 305, 73 (1980).
19. A. R. Martin and G. Pilar, ibid. 168, 443 (1963); E. F. Stanley and G. Goping, J. Neurosci. 11, 985 (1991); H, Yawo and A. Momiyama, J. Physiol. (London) 460, 153 (1993).
20. A. R. Martin and G. Pilar, ibid. 168, 443 (1963); E. F. Stanley and G. Goping, J. Neurosci. 11, 985 (1991); H, Yawo and A. Momiyama, J. Physiol. (London) 460, 153 (1993).
21. A. R. Martin and G. Pilar, ibid. 168, 443 (1963); E. F. Stanley and G. Goping, J. Neurosci. 11, 985 (1991); H, Yawo and A. Momiyama, J. Physiol. (London) 460, 153 (1993).
22. I. D. Forsythe, J. Physiol. (London) 479, 381 (1994).
23. J. G. G. Borst, F. Helmchen, B. Sakmann. ibid. 489, 825 (1995).
24. 2, 2 mM adenosine triphospnate (ATP), 0.5 mM guanosine triphosphate (GTP), 12 mM phosphocreatinine, and 10 mM TEA (pH adjusted to 7.4 with CsOH); 10 mM cesium glutamate was added in replacement with equimolar CsCl in some experiments. For recording presynaptic potassium currents, TEA was omitted from aCSF solution and the pipette was filled with the postsynaptic solution including ATP, GTP, and phosphocreatinine at the above concentrations. Recordings were made at room temperature (22° to 25°C). The liquid junction potential between the pipette and aCSF (+2 mV) was not corrected. The electrode resistances were 5 to 10 megohms for the postsynaptic pipette and 7 to 12 megohms for the presynaptic pipette. Series resistances (10 to 30 megohms) were compensated by 50 to 90%. Records were low-pass filtered at 2 to 10 kHz and digitized at 5 to 27 kHz by means of a CED 1401 interface (Cambridge Electronic Design). Leak currents were subtracted for presynaptic currents by a P/N protocol.
25. 2, 2 mM adenosine triphospnate (ATP), 0.5 mM guanosine triphosphate (GTP), 12 mM phosphocreatinine, and 10 mM TEA (pH adjusted to 7.4 with CsOH); 10 mM cesium glutamate was added in replacement with equimolar CsCl in some experiments. For recording presynaptic potassium currents, TEA was omitted from aCSF solution and the pipette was filled with the postsynaptic solution including ATP, GTP, and phosphocreatinine at the above concentrations. Recordings were made at room temperature (22° to 25°C). The liquid junction potential between the pipette and aCSF (+2 mV) was not corrected. The electrode resistances were 5 to 10 megohms for the postsynaptic pipette and 7 to 12 megohms for the presynaptic pipette. Series resistances (10 to 30 megohms) were compensated by 50 to 90%. Records were low-pass filtered at 2 to 10 kHz and digitized at 5 to 27 kHz by means of a CED 1401 interface (Cambridge Electronic Design). Leak currents were subtracted for presynaptic currents by a P/N protocol.
26. T. Takahashi and A. Momiyama, Nature 366, 156 (1993); D. B. Wheeler. A. Randall. R. W, Tsien, Science 264, 107 (1994); S. Sivaramakrishnan and G. Laurent, J, Neurosci. 15, 6576 (1995).
27. T. Takahashi and A. Momiyama, Nature 366, 156 (1993); D. B. Wheeler. A. Randall. R. W, Tsien, Science 264, 107 (1994); S. Sivaramakrishnan and G. Laurent, J, Neurosci. 15, 6576 (1995).
28. T. Takahashi and A. Momiyama, Nature 366, 156 (1993); D. B. Wheeler. A. Randall. R. W, Tsien, Science 264, 107 (1994); S. Sivaramakrishnan and G. Laurent, J, Neurosci. 15, 6576 (1995).
29. T. Takahashi, T. Tsujimoto, K. Onodera, I. D. Forsythe, M. Barnes-Davies, data not shown.
30. G. J Augustine and M. P. Charlton, J. Physiol. (London) 381. 619 (1986).
31. R. Anwyl, Brain Res. Rev. 16, 265 (1991).
32. L.-G. Wu and P. Saggau, Neuron 12, 1139 (1994); J. Physiol. (London) 485, 649 (1995); J. S. Dittman and W. G. Regehr, J. Neurosci. 16. 1623(1996).
33. L.-G. Wu and P. Saggau, Neuron 12, 1139 (1994); J. Physiol. (London) 485, 649 (1995); J. S. Dittman and W. G. Regehr, J. Neurosci. 16. 1623(1996).
34. L.-G. Wu and P. Saggau, Neuron 12, 1139 (1994); J. Physiol. (London) 485, 649 (1995); J. S. Dittman and W. G. Regehr, J. Neurosci. 16. 1623(1996).
35. S. A. Siegelbaum, J. S. Carmado, E. R. Kandel, Nature 299, 413 (1982).
36. W.-m. Fu and M.-m. Poo, Neuron 6, 837 (1991); Y. Hori, K. Endo, T. Takahashi, J. Physiol. (London) 492, 867 (1996).
37. W.-m. Fu and M.-m. Poo, Neuron 6, 837 (1991); Y. Hori, K. Endo, T. Takahashi, J. Physiol. (London) 492, 867 (1996).
38. H. Ohishi et al., Neuron 13, 55 (1994); J. Comp. Neurol. 360, 555 (1995); R. Shigemoto et al., Nature 381,523 (1996).
39. H. Ohishi et al., Neuron 13, 55 (1994); J. Comp. Neurol. 360, 555 (1995); R. Shigemoto et al., Nature 381,523 (1996).
40. H. Ohishi et al., Neuron 13, 55 (1994); J. Comp. Neurol. 360, 555 (1995); R. Shigemoto et al., Nature 381,523 (1996).
41. We thank M. Farrant, T. Manabe, and K. Kobayashi for comments on early drafts and Y. Ofune for DCG-IV Supported by a grant-in-aid for scientific research from the Ministry of Education of Japan, the Wellcome Trust, and a travel grant from Yamada Science Foundation. I.D.F. is a Wellcome Senior Research Fellow in Basic Biomedical Sciences.