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Volumn 6, Issue 12, 2001, Pages 628-636

Transgenic knockouts as part of high-throughput, evidence-based target selection and validation strategies

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; BIOLOGY; BIOTECHNOLOGY; DRUG INDUSTRY; EVIDENCE BASED MEDICINE; GENE EXPRESSION; GENE SEQUENCE; GENERAL ASPECTS OF DISEASE; GENOME; HUMAN; KNOCKOUT GENE; KNOCKOUT MOUSE; MOLECULAR GENETICS; NONHUMAN; PHENOTYPE; SHORT SURVEY; TRANSGENE; TRANSGENIC ANIMAL; VALIDATION PROCESS;

EID: 0035368874     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(01)01794-9     Document Type: Review
Times cited : (28)

References (24)
  • 2
    • 0001049464 scopus 로고    scopus 로고
    • Obtaining value from the human genome: a challenge for the pharmaceutical industry
    • (1998) Drug Discov. Today , vol.3 , pp. 179-188
    • Spence, P.1
  • 6
    • 0034677966 scopus 로고    scopus 로고
    • Drug discovery: a historical perspective
    • (2000) Science , vol.287 , pp. 1960-1964
    • Drews, J.1
  • 7
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • (2001) Nature , vol.409 , pp. 860-921
  • 11
    • 0034616912 scopus 로고    scopus 로고
    • Biomedical discovery with DNA arrays
    • (2000) Cell , vol.102 , pp. 9-15
    • Young, R.A.1
  • 12
    • 10644231968 scopus 로고    scopus 로고
    • Experimentalism in Proteomics
    • Blackstock W., Mann M. (Eds.), Proteomics: A Trends Guide, Elsevier Science
    • (2000) , pp. 7-11
    • Thomas, J.D.1    VanBogelen, R.A.2
  • 13
    • 0033485278 scopus 로고    scopus 로고
    • Antisense oligonucleotides: a systematic high-throughput approach to target validation and gene function determination
    • (1999) Drug Discov. Today , vol.4 , pp. 562-567
    • Taylor, M.F.1
  • 15
    • 0031021132 scopus 로고    scopus 로고
    • Mouse models of human disease. Part I: techniques and resources for genetic analysis in mice
    • (1997) Genes Dev. , vol.11 , pp. 1-10
    • Bedell, M.A.1
  • 16
    • 0031028759 scopus 로고    scopus 로고
    • Mouse models of human disease. Part II: recent progress and future directions
    • (1997) Genes Dev. , vol.11 , pp. 11-43
    • Bedell, M.A.1
  • 17
    • 0032936730 scopus 로고    scopus 로고
    • Transgenic mouse mutation assay systems can play an important role in regulatory mutagenicity testing in vivo for the detection of site-of-contact mutagens
    • (1999) Mutagenesis , vol.14 , pp. 141-151
    • Dean, S.W.1
  • 18
    • 0034654038 scopus 로고    scopus 로고
    • Current status and use of short/medium term models for carcinogenicity testing of pharmaceuticals - scientific perspective
    • (2000) Toxicol. Lett. , vol.112 , pp. 557-566
    • Storer, R.D.1
  • 24
    • 0032499252 scopus 로고    scopus 로고
    • Disruption and sequence identification of 2000 genes in mouse embryonic stem cells
    • (1998) Nature , vol.392 , pp. 608-611
    • Zambrowicz, B.P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.