Role of a new Rho family member in cell migration and axon guidance in C. elegans

Cell

Volumn 90, Issue 5, 1997, Pages 883-894

  Zipkin, Man D ^a,b   Kindt, Rachel M ^a   Kenyon, Cynthia J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b BioCentury Publications   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GUANOSINE TRIPHOSPHATASE;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CELL MIGRATION; GENE MUTATION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY;

ANIMALIA; CAENORHABDITIS ELEGANS;

EID: 0030866898     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)80353-0     Document Type: Article

References (38)

1. Adamson, P., Marshall, C.J., Hall, A., and Tilbrook, P.A. (1992). Posttranslational modification of p21rho proteins. J. Biol. Chem. 267, 20033-20038.
2. Beitel, G.J., Clark, S.G., and Horvitz, H.R. (1990). The Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction. Nature 345, 503-509.
3. Bourne, H.R., Sanders, D.A.,and McCormick, F. (1991). The GTPase superfamily: conserved structure and molecular mechanism. Nature 349, 117-127.
4. Chant, J. (1996). Generation of cell polarity in yeast. Curr. Opin. Cell Biol. 8, 557-565.
5. Chen, W., and Lim, L. (1994). The Caenorhabditis elegans small GTP-binding protein RhoA is enriched in the nerve ring and sensory neurons during larval development. J. Biol. Chem. 269, 32394-32404.
6. Chen, W., Lim, H.H., and Lim, L. (1993a). A new member of the ras superfamily, the rac1 homologue from Caenorhabditis elegans. J. Biol. Chem. 265, 320-324.
7. Chen, W., Lim, H.H., and Lim, L. (1993b). The CDC42 homologue from Caenorhabditis elegans. J. Biol. Chem. 266, 13280-13285.
8. Chen, W.N., Yap, S.F., and Lim, L. (1996). Isolation of the gene coding for Caenorhabditis elegans Rac2 homologue, a Ras-related small GTP-binding protein. Gene 180, 217-219.
9. Clark, D.V., Suleman, D.S., Beckenbach, K.A., Gilchrist, E.J., and Baillie, D.L. (1995). Molecular cloning and characterization of the dpy-20 gene of C. elegans. Mol. Gen. Genet. 247, 367-378.
10. Desai, C., Garriga, G., McIntire, S.L., and Horvitz, H.R. (1988). A genetic pathway forthe development of the Caenorhabditis elegans HSN motor neurons. Nature 336, 638-646.
11. DeVore, D.L., Horvitz, H.R., and Stern, M.J. (1995). An FGF receptor signaling pathway is required for the normal migrations of the sex myoblasts in C. elegans hermaphrodites. Cell 83, 611-620.
12. Diekmann, D., Nobes, C.D., Burbelo, P.D., Abo, A., and Hall, A. (1995). Rac GTPase interacts with GAPs and target proteins through multiple effector sites. EMBO J. 14, 5297-5305.
13. Feig, L.A., and Cooper, G.M. (1988). Relationship among guanine nucleotide exchange, GTP hydrolysis and transforming potential of mutated ras proteins. Mol. Cell Biol. 8, 2472-2478.
14. Forrester, W.C., and Garriga, G. (1997). Genes necessary for C. elegans cell and growth cone migrations. Development 724, 1831-1843.
15. Garriga, G., Desai, G., and Horvitz, H.R. (1993). Cell interactions control the direction of outgrowth, branching and fasciculation of the HSN axons of Caenorhabditis elegans. Development 117, 1071-1087.
16. Harris, J., Honigberg, L., Robinson, N., and Kenyon, C. (1996). Neuronal cell migration in C. elegans: regulation of Hox gene expression and cell position. Development 122, 3117-3131.
17. Hedgecock, E.M., Culotti, J.G., Hall, D.H., and Stern, B.D. (1987). Genetics of cell and axon migrations in Caenorhabditis elegans. Development 100, 365-382.
18. Johnson, D.I., and Pringle, J.R. (1990). Molecular characterization of CDC42, a Saccharomyces cerevisiae gene involved in the development of cell polarity. J. Cell Biol. 111, 143-152.
19. Krause, M., and Hirsh, D. (1987). A trans-spliced leader sequence on actin mRNA in C. elegans. Cell 49, 753-761.
20. Krengel, U., Schlichting, L, Scherer, A., Schumann, R., Frech, M., John, J., Kabsch, W., Pai, E.F., and Wittinghofer, A. (1990). Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell 62, 539-548.
21. Larochelle, D.A., Vlthalani, K.K., and De Lozanne, A. (1996). A novel member of the rho family of small GTP-binding proteins is specifically required for cytokinesis. J. Cell Biol. 133, 1321-1329.
22. Luo, L, Liao, J., Jan, L.Y., and Jan, Y.N. (1994). Distinct morphogenetic functions of similar small GTPases: Drospohila Drad is involved in axonal outgrowth and myoblast fusion. Genes Dev. 8, 1787-1802.
23. Luo, L, Hensch, T.K., Ackerman, L., Barbel, S., Jan, L.Y., and Jan, Y.N. (1996). Differential effects of the Rac GTPase on Purkinje cell axons and dendritic trunks and spines. Nature 379, 837-840.
24. Mclntire, S.L., Garriga, G., White, J., Jacobson, D., and Horvitz, H.R. (1992). Genes necessary for directed axonal elongation or fasciculation in C. elegans. Neuron 8, 307-322.
25. Mello, G.G., Kramer, J.M., Stinchcomb, D., and Ambras, V. (1991). Efficient gene transfer in C. elegans: extrachromosomal maintenance and integration of transforming sequences. EMBO J. 10, 3959-3970.
26. Murphy, A.M., and Montell, D.J. (1996). Cell type-specific roles for Cdc42, Rac, and RhoL in Drosophila oogenesis. J. Cell Biol. 133, 617-630.
27. Nobes, C., and Hall, A. (1994). Regulation and function of the Rho subfamily of small GTPases. Curr. Opin. Genet. Dev. 4, 77-81.
28. Nobes, C.D., and Hall, A. (1995). Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81, 53-62.
29. Ridley, A.J. (1995). Rho-related proteins: actin cytoskeleton and cell cycle. Curr. Opin. Genet. Dev. 5, 24-30.
30. Ridley, A.J., and Hall, A. (1992). The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70, 389-399.
31. Ridley, A.J., Paterson, H.F., Johnston, C.L., Diekmann, D., and Hall, A. (1992). The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70, 401-410.
32. Run, J.-Q., Steven, R., Hung, M.-S., van Weeghel, R., Culotti, J.G., and Way, J.C. (1996). Suppressors of the unc-73 gene of Caenorhabditis elegans. Genetics 143, 225-236.
33. Ruvkun, G., Ambros, V., Coulson, A., Waterston, R., Sulston, J., and Horvitz, H.R. (1989). Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14. Genetics 121, 501-516.
34. Seeburg, P.H., Colby, W.W., Capon, D.J., Goeddel, D.V., and Levinson, A.D. (1984). Biological properties of human c-Ha-ras1 genes mutated at codon 12. Nature 312, 71-75.
35. Sulston, J., and Horvitz, H.R. (1977). Postembryonic cell lineages of the nematode, Caenorhabditis elegans. Dev. Biol. 56, 110-156.
36. Sulston, J., and Hodgkin, J. (1988). Methods. In The Nematode Caenorhabditis elegans, W.B. Wood, ed. (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press), pp. 587-605.
37. Wang, B.B., Muller-Immergluck, M.M., Austin, J., Robinson, N.T., Chisholm, A., and Kenyon, C. (1993). A homeotic gene cluster patterns the anteroposterior body axis of C. elegans. Cell 74, 29-42.
38. Williams, B.D., Schrank, B., Huynh, C., Shownkeen, R., and Waterston, R.H. (1992). A genetic mapping system in Caenorhabditis elegans based on polymorphic sequence-tagged sites. Genetics 131, 609-624.