Cdc42 stimulates neurite outgrowth and formation of growth cone filopodia and lamellipodia

Journal of Neurobiology

Volumn 43, Issue 4, 2000, Pages 352-364

  Brown, Michael D ^a   Cornejo, Brandon J ^a   Kuhn, Thomas B ^a,b   Bamburg, James R ^a  

^a Immunology and Pathology   (United States)

^b UNIVERSITY OF ALASKA FAIRBANKS   (United States)

Author keywords

Actin; Adenoviral mediated gene transfer; Laminin; Neural development; Rho GTPases

Indexed keywords

LAMIN;

ANIMAL CELL; ARTICLE; CELL STRUCTURE; CHICKEN; GROWTH RATE; IMMUNOFLUORESCENCE; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ACTINS; ANIMALS; CDC42 GTP-BINDING PROTEIN; CELLS, CULTURED; CHICK EMBRYO; DOWN-REGULATION; GENES, DOMINANT; GROWTH CONES; LAMININ; MUTATION; NEURITES; NEURONS; PSEUDOPODIA; SPINAL CORD; TISSUE DISTRIBUTION;

EID: 0034660180     PISSN: 00223034     EISSN: None     Source Type: Journal    
DOI: 10.1002/1097-4695(20000615)43:4<352::AID-NEU4>3.0.CO;2-T     Document Type: Article

References (41)

1. Bamburg JR, Minamide LS, Morgan TE, Hayden SM, Giuliano KA, Koffer A. 1991. Purification and characterization of low-molecular weight actin-depolymerizing proteins from brain and cultured cells. Methods Enzymol 196:125-140.
2. Bentley D, O'Connor TP. 1994. Cytoskeletal events in growth cone steering. Curr Opin Neurobiol 4:43-48.
3. Caroni P. 1998. Driving the growth cone. Science 281: 1465-1466
4. Colucci-D'Amato GL, Santelli G, D'Alessio A, Chiappetta G, Mineo A, Manzo G, Vecchio G, de Franciscis V. 1995. Dbl expression driven by the neuron specific enolase promoter induces tumor formation in transgenic mice with a p53(+/-) genetic background. Biochem Biophys Res Commun 216:762-770.
5. Goodman CS. 1996. Mechanisms and molecules that control growth cone guidance. Annu Rev Neurosci 19:341-377.
6. Hall A. 1998. Rho GTPases and the actin cytoskeleton. Science 279:509-514.
7. Höpker VH, Shewan D, Tessier-Lavigne M, Poo M-m, Holt C. 1999. Growth cone attraction to netrin-1 is converted to repulsion by laminin-1. Nature 401:69-73.
8. Horii Y, Beeler JF, Sakaguchi K, Tachibana M, Miki T. 1994. A novel oncogene, ost, encodes a guanine nucleotide exchange factor that potentially links rho and rac signaling pathways. EMBO J 13:4776-4786.
9. Jalink K, van Corvan EJ, Hengeveld T, Morii N, Narumiya S, Moolenaar WH. 1994. Inhibition of lysophosphatidate-and thrombin-induced neurite retraction and neuronal cell founding by ADF ribosylation of the small GTP-binding protein rho. J Cell Biol 126:801-810.
10. Jin Z, Strittmatter SM. 1997. Rac1 mediates collapsin-1-induced growth cone collapse. J Neurosci 17:6256-6263.
11. Kaufmann N, Wills ZP, Van Vactor D. 1998. Drosophila Rac1 controls motor axon guidance. Development 125: 453-461.
12. Kozma R, Ahmed S, Best A, Lim L. 1995. The ras-related protein cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 tibroblasts. Mol Cell Biol 15:1942-1952.
13. Kozma R, Sarner S, Ahmed S, Lim L. 1997. Rho family GTPases and neuronal growth cone remodelling: relationship between increased complexity induced by cdc42Hs, rac1, and acetylcholine and collapse induced by rhoA and lysophosphatidic acid. Mol Cell Biol 17:1201-1211.
14. Kuhn TB, Schmidt MF, Kater SB. 1995. Laminin and fibronectin guideposts signal sustained but opposite effects to passing growth cones. Neuron 14:275-285.
15. Kuhn TB, Brown MD, Bamburg JR. 1998. Rac1-dependent actin filament organization in growth cones is necessary for β1 integrin-mediated advance but not for growth on poly-D-lysine. J Neurobiol 37:524-540.
16. Kuhn TB, Brown MD, Wilcox CL, Raper JA, Bamburg JR. 1999. Myelin and collapsin-1 induce motor neuron growth cone collapse through different pathways: inhibition of collapse by opposing mutants of rac1. J Neurosci 19:1965-1975.
17. Kuhn TB, Meberg PJ, Brown MD, Bernstein BW, Minamitle LS, Jensen JR, Okada K, Soda EA, Bamburg JR. 2000. Regulating actin dynamics in neuronal growth cones by ADF/cofilin and rho family GTPases. J Neurobiol, (In press).
18. Laemmli UK. 1970. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227:680-684.
19. Lang P, Gesbert F, Delespine-Carmagnat M, Stancou R, Pouchelet M, Bertoglio J. 1996. Protein kinase A phosphorylation of RhoA mediates the morphological and functional effects of cAMP in cytotoxic lymphocytes. EMBO J 15:510-519.
20. Lewis AK, Bridgman PC. 1992. Nerve growth cone lamellipodia contain two populations of actin filaments that differ in organization and polarity. J Cell Biol 119:1219-1243.
21. Lin C-H, Forscher P. 1993. Cytoskeletal remodeling during growth cone-target interactions. J Cell Biol 121:1369-1383.
22. Lorenzi MV, Castagnino P, Chen Q, Hori Y, Miki T. 1999. Distinct expression patterns and transforming properties of multiple isoforms of ost, an exchange factor for RhoA and cdc42. Oncogene 18:4742-4755.
23. Luo L, Lioa YJ, Jan LY, Jan YN. 1994. Distinct morphogenetic functions of similar small GTPAses: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion. Genes Dev 8:1787-1802.
24. Luo L, Hensch TK, Ackerman L, Barbel S, Jan LY, Jan YN. 1996a. Differential effects of the rac1 GTPase on Purkinje cell axons and dendritic trunks and spines. Nature 379:837-840.
25. Luo L, Jan L, Jan YN. 1996b. Small GTPases in axon outgrowth. Perspect Dev Neurobiol 4:199-204.
26. Meberg PJ, Bamburg JR. 2000. Increases in neurite outgrowth mediated by overexpression of actin depolymerizing factor. J Neurosci 20:2459-2469.
27. Minamide LS, Bamburg JR. 1990. A filter paper dye-binding assay for quantitative determination of protein without interference from reducing agents or detergents. Anal Biochem 190:66-70.
28. Mueller BK. 1999. Growth cone guidance: first steps towards a deeper understanding. Annu Rev Neurosci 22: 351-388.
29. Nobes CD, Hall A. 1995. Rho, rac, and cdc42 GTPases regulate the assembly of multi-molecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81:53-62.
30. O'Connor TP, Bentley D. 1993. Accumulation of actin in subsets of pioneer growth cone filopodia in response to neural and epithelial guidance cues in situ. J Cell Biol 123:935-948.
31. Olenik C, Barth H, Just I, Aktories K, Meyer DK. 1997. Gene expression of the small GTP-binding proteins RhoA, RhoB, Rac1, and Cdc42 in adult rat brain. Brain Res Mol Brain Res 52:263-269.
32. Rivas RJ, Burmeister DW, Goldberg DJ. 1992. Rapid effects of laminin on the growth cone. Neuron 8:107-115.
33. Song H-j, Poo M-m. 1999. Signal transduction underlying growth cone guidance by diffusible factors. Curr Opin Neurobiol 9:355-363.
34. Song H-j, Ming G, He Z, Lehmann M, McKerracher L, Tessier-Lavigne M, Poo M-m. 1998. Conversion of neuronal growth cone responses from repulsion to attraction by cyclic nucleotides. Science 281:1515-1518.
35. Sumi T, Matsumoto K, Takai Y, Nakamura T. 1999. Cofilin phosphorylation and actin cytoskeletal dynamics regulated by rho-and Cdc42-activated LIM-kinase 2. J Cell Biol 147:1519-1532.
36. Suter DM, Forscher P. 1998. An emerging link between cytoskeletal dynamics and cell adhesion molecules in growth cone guidance. Curr Opin Neurobiol 8:106-116.
37. Tanaka E, Sabry J. 1995. Making the connection: cytoskeletal rearrangements during growth cone guidance. Cell 83:171-176.
38. Threadgill R, Bobb K, Ghosh A. 1997. Regulation of dendritic growth and remodeling by rho, rac, and cdc42. Neuron 19:625-634.
39. 2+ signaling and Rho. J Neurochem 66:537-548.
40. Towbin H, Staehelin T, Gordon J. 1979. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 76:4350-4354.
41. Wessel D, Flügge UI. 1984. A method for the quantitative recovery of protein in dilute solution in the presence of detergents and lipids. Anal Biochem 138:141-143.