Srm160 splicing coactivator promotes transcript 3′-end Cleavage

Molecular and Cellular Biology

Volumn 22, Issue 1, 2002, Pages 148-160

  McCracken, S ^a   Lambermon, M ^a   Blencowe, B J ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; MESSENGER RNA; MESSENGER RNA PRECURSOR; NUCLEAR PROTEIN; PROTEIN SRM160; SERINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; HUMAN; HUMAN CELL; POLYADENYLATION; PRIORITY JOURNAL; RNA CLEAVAGE; RNA PROCESSING; RNA SPLICING;

ACTIVE TRANSPORT, CELL NUCLEUS; ANTIGENS, NUCLEAR; CELL FRACTIONATION; CELL LINE; GENES, REPORTER; HUMANS; MRNA CLEAVAGE AND POLYADENYLATION FACTORS; NUCLEAR MATRIX-ASSOCIATED PROTEINS; NUCLEAR PROTEINS; RECOMBINANT PROTEINS; RNA 3' END PROCESSING; RNA PRECURSORS; RNA SPLICING; RNA, MESSENGER; RNA-BINDING PROTEINS;

EID: 0036132667     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.22.1.148-160.2002     Document Type: Article

References (49)

1. Transcriptional termination in the Balbiani ring 1 gene is closely coupled to 3′-end formation and excision of the 3′-terminal intron
2. Coupling termination of transcription to messenger RNA maturation in yeast
3. The SRm160/300 splicing coactivator subunits
4. SR-related proteins and the processing of messenger RNA precursors
5. A coactivator of pre-mRNA splicing
6. Association of nuclear matrix antigens with exon-containing splicing complexes
7. Regulation by HIV Rev depends upon recognition of splice sites
8. Mechanism and regulation of mRNA polyadenylation
9. Inefficient processing impairs release of RNA from the site of transcription
10. Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors
11. The SRm160/300 splicing coactivator is required for exon-enhancer function
12. Participation of the nuclear cap binding complex in pre-mRNA 3′ processing
13. The superfamily of arginine/serine-rich splicing factors
14. Sorting out the complexity of SR protein functions
15. U1 snRNP inhibits pre-mRNA polyadenylation through a direct interaction between U1 70K and poly(A) polymerase
16. Involvement of the carboxyl terminus of vertebrate poly(A) polymerase in U1A autoregulation and in the coupling of splicing and polyadenylation
17. RNA polymerase II and the integration of nuclear events
18. Role of polyadenylation in nucleocytoplasmic transport of mRNA
19. Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA
20. A nuclear cap binding protein complex involved in pre-mRNA splicing
21. Pre-mRNA splicing imprints mRNA in the nucleus with a novel RNA-binding protein that persists in the cytoplasm
22. The structure and function of proteins involved in mammalian pre-mRNA splicing
23. Some cis- and trans-acting mutants for splicing target pre-mRNA to the cytoplasm
24. The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions
25. A nuclear cap-binding complex facilitates association of U1 snRNP with the cap-proximal 5′ splice site
26. Regulation of alternative polyadenylation by U1 snRNPs and SRp20
27. Splicing is required for rapid and efficient mRNA export in metazoans
28. Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro
29. Role of RNA polymerase II carboxy-terminal domain in coordinating transcription with RNA processing
30. The acute myeloid leukemia-associated protein, DEK, forms a splicing-dependent interaction with exon-product complexes
31. Site-specific polyadenylation in a cell-free reaction
32. Upstream introns influence the efficiency of final intron removal and RNA 3′-end formation
33. Mutation of the AAUAAA polyadenylation signal depresses in vitro splicing of proximal but not distal introns
34. In vitro polyadenylation is stimulated by the presence of an upstream intron
35. Identification of a putative RNA helicase (HRH1), a human homolog of yeast Prp22
36. Connecting transcription to messenger RNA processing
37. REF proteins mediate the export of spliced and unspliced mRNAs from the nucleus
38. Overexpression of the arginine-rich carboxy-terminal region of U1 snRNP 70K inhibits both splicing and nucleocytoplasmic transport of mRNA
39. Human pre-mRNA cleavage factor Im is related to spliceosomal SR proteins and can be reconstituted in vitro from recombinant subunits
40. A dual role for BBP/ScSF1 in nuclear pre-mRNA retention and splicing
41. The carboxyl terminus of vertebrate poly(A) polymerase interacts with U2AF 65 to couple 3′-end processing and splicing
42. The biochemistry of polyadenylation
43. The B1C8 protein is in the dense assemblies of the nuclear matrix and relocates to the spindle and pericentriolar filaments at mitosis
44. Overexpression of the SR proteins ASF/SF2 and SC35 influences alternative splicing in vivo in diverse ways
45. Association with terminal exons in pre-mRNAs: A new role for the U1 snRNPΔ
46. Transcriptional elongation by RNA polymerase II is stimulated by transactivators
47. The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans