The SRm160/300 splicing coactivator subunits

RNA

Volumn 6, Issue 1, 2000, Pages 111-120

  Blencowe, Benjamin J ^a,b   Baurén, Göran ^a,d   Eldridge, Adam G ^a,b,e   Issner, Robbyn ^a,f   Nickerson, Jeffrey A ^c   Rosonina, Emanuel ^b   Sharp, Phillip A ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^d STOCKHOLM UNIVERSITY   (Sweden)

^e STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f ARIAD PHARMACEUTICALS INC   (United States)

Author keywords

Nuclear matrix; snRNP; Spliceosome; SR protein

Indexed keywords

ARGININE; COMPLEMENTARY DNA; MESSENGER RNA PRECURSOR; NUCLEAR PROTEIN; RNA; SERINE; SMALL NUCLEAR RIBONUCLEOPROTEIN;

ARTICLE; BACULOVIRUS; CELL NUCLEUS MATRIX; GENE EXPRESSION; HELA CELL; MOLECULAR CLONING; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; RNA SPLICING; SPLICEOSOME;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIGENS, NUCLEAR; CELL NUCLEUS; CELLS, CULTURED; CLONING, MOLECULAR; DNA, COMPLEMENTARY; HUMANS; MOLECULAR SEQUENCE DATA; NUCLEAR MATRIX-ASSOCIATED PROTEINS; NUCLEAR PROTEINS; PRECIPITIN TESTS; RNA SPLICING; RNA, MESSENGER; RNA-BINDING PROTEINS; SPLICEOSOMES;

UNIDENTIFIED BACULOVIRUS;

EID: 0033984807     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838200991982     Document Type: Article

References (47)

1. Beil B, Screaton G, Stamm S. 1997. Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing. DNA Cell Biol 16:679-691.
2. Blencowe BJ, Bowman JAL, McCracken S, Rosonina E. 1999. SR-related proteins and the processing of messenger RNA precursors. Biochem Cell Biol 77:277-291.
3. Blencowe BJ, Issner R, Kim J, McCaw P, Sharp PA. 1995. New proteins related to the Ser-Arg family of splicing factors. RNA 1:852-865.
4. Blencowe BJ, Issner R, Nickerson JA, Sharp PA. 1998. A coactivator of pre-mRNA splicing. Genes & Dev 12:996-1009.
5. Blencowe BJ, Nickerson JA, Issner R, Penman S, Sharp PA. 1994. Association of nuclear matrix antigens with exon-containing splicing complexes. J Cell Biol 127:593-607.
6. Blencowe BJ, Ouzounis CA. 1999. The PWI motif: A new protein domain in splicing factors. Trends Biochem Sci 24:179-180.
7. Bourquin JP, Stagljar I, Meier P, Moosmann P, Silke J, Baechi T, Georgiev O, Schaffner W. 1997. A serine/arginine-rich nuclear matrix cyclophilin interacts with the C-terminal domain of RNA polymerase II. Nucleic Acids Res 11:2055-2061.
8. Brendel V, Bucher P, Nourbakhsh I, Blaisdell BE, Karlin S. 1992. Methods and algorithms for statistical analysis of protein sequences. Proc Natl Acad Sci USA 89:2002-2006.
9. Cáceres JF, Stamm S, Helfman DM, Krainer AR. 1994. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science 265:1706-1709.
10. Colwill K, Pawson T, Andrews B, Prasad J, Manley J, Bell J, Duncan P. 1996. The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. EMBO J 15:265-275.
11. Dauwalder B, Amaya-Manzanares F, Mattox W. 1996. A human homolog of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions. Proc Natl Acad Sci USA 93:9004-9009.
12. de la Cruz J, Kressler D, Linder P. 1999. Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families. Trends Biochem Sci 24:192-198.
13. Denhez F, Lafyatis R. 1994. Conservation of regulated alternative splicing and identification of functional domains in vertebrate homologs to the Drosophila regulator, suppressor-of-white-apricot. J Biol Chem 269:16170-16179.
14. Dignam JD, Lebovitz RM, Roeder RD. 1983. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res 11:1475-1489.
15. Dirksen WP, Hampson RK, Sun Q, Rottman FM. 1994. A purine-rich exon sequence enhances alternative splicing of bovine growth hormone pre-mRNA. J Biol Chem 269:6431-6436.
16. Eldridge AG, Li Y, Sharp PA, Blencowe BJ. 1999. The SRm160/300 splicing coactivator is required for exon-enhancer function. Proc Natl Acad Sci USA 96:6125-6130.
17. Fu X-D. 1995. The superfamily of arginine/serine-rich splicing factors. RNA 1:663-680.
18. Fu X-D, Mayeda A, Maniatis T, Krainer AR. 1992. General splicing factors SF2 and SC35 have equivalent activities in vitro, and both affect alternative 5′ and 3′ splice site selection. Proc Natl Acad Sci USA 89:11224-11228.
19. Ge H, Manley JL 1990. A protein factor, ASF, controls cell specific alternative splicing of SV40 early pre-mRNA in vitro. Cell 62:25-34.
20. Gui J-F, Lane WS, Fu X-D. 1994a. A serine kinase regulates intracellular localization of splicing factors in the cell cycle. Nature 369:678-682.
21. Gui J-F, Tronchere H, Chandler SD, Fu X-D. 1994b. Purification and characterization of a kinase specific for the serine-and arginine-rich pre-mRNA splicing factors. Proc Natl Acad Sci USA 91:10824-10828.
22. Harlow E, Lane D. 1988. Antibodies: A laboratory manual. Cold Spring Harbor, New York: Cold Spring Harbor Laboratory Press.
23. Inoue K, Hoshijima K, Higuchi I, Sakamoto H, Shimura Y. 1992. Binding of the Drosophila transformer and transformer-2 proteins to the regulatory elements of doublesex primary transcript for sex-specific RNA processing. Proc Natl Acad Sci USA 89:8092-8096.
24. Krainer AR, Conway GC, Kozak D. 1990a. The essential pre-mRNA splicing factor SF2 influences 5′ splice site selection by activating proximal sites. Cell 62:35-42.
25. Krainer AR, Conway GC, Kozak D. 1990b. Purification and characterization of pre-mRNA splicing factor SF2 from HeLa cells. Genes & Dev 4:1158-1171.
26. Lavigueur A, Branche HL, Kornblihtt A, Chabot B. 1993. A splicing enhancer in the human fibronectin alternate ED1 exon interacts with SR proteins and stimulates U2 snRNP binding. Genes & Dev 7:2405-2417.
27. Lopez AJ. 1998. Alternative splicing of pre-mRNA: Developmental consequences and mechanisms of regulation. Annu Rev Genet 32:279-305.
28. Manley J, Tacke R. 1996. SR proteins and splicing control. Genes & Dev 10:1569-1579.
29. Mayeda A, Badolato J, Kobayashi R, Zhang MQ, Gardiner EM, Krainer AR. 1999. Purification and characterization of human RNPS1: A general activator of pre-mRNA splicing. EMBO J 18:4560-4570.
30. Meier U, Blobel G. 1992. Nopp140 shuttles on tracks between nucleus and cytoplasm. Cell 70:127-138.
31. Misteli T. 1999. RNA splicing: What has phosphorylation got to do with it? Curr Biol 9:R198-R200.
32. Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O. 1997. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res 4:141-150.
33. Roscigno R, Garcia-Blanco M. 1995. SR proteins escort the U4/ U6.U5 tri-snRNP to the spliceosome. RNA 1:692-706.
34. Spikes DA, Kramer J, Bingham PM, Van Doren K. 1994. SWAP pre-mRNA splicing regulators are a novel, ancient protein family sharing a highly conserved sequence motif with the prp21 family of constitutive splicing proteins. Nucleic Acids Res 22:4510-4519.
35. Sun Q, Mayeda A, Hampson RK, Krainer AR, Rottman FM. 1993. General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes & Dev 7:2598-2608.
36. Tacke R, Tohyama M, Ogawa S, Manley JL. 1998. Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Cell 93:139-148.
37. Tanaka K, Watakabe A, Shimura Y. 1994. Polypurine sequences within a downstream exon function as a splicing enhancer. Mol Cell Biol 14:1347-1354.
38. Tian M, Maniatis T. 1993. A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA. Cell 74:105-114.
39. Tian M, Maniatis T. 1994. A splicing enhancer exhibits both constitutive and regulated activities. Genes & Dev 8:1703-1712.
40. Valcarcel J, Green MR. 1996. The SR protein family: Pleiotropic functions in pre-mRNA splicing. Trends Biochem Sci 21:296-301.
41. Wan K, Nickerson JA, Krockmalnic G, Penman S. 1994. The B1C8 protein is in the dense assemblies of the nuclear matrix and relocates to the spindle and pericentriolar filaments at mitosis. Proc Natl Acad Sci USA 97:594-598.
42. Wang J, Manley JL. 1995. Overexpression of the SR proteins ASF/ SF2 and SC35 influences alternative splicing in vivo in diverse ways. RNA 1:346-355.
43. Yeakley JM, Morfin JP, Rosenfeld MG, Fu XD. 1996. A complex of nuclear proteins mediates SR protein binding to a purine-rich splicing enhancer. Proc Natl Acad Sci USA 93:7582-7587.
44. Yuryev A, Patturajan M, Litingtung Y, Joshi RV, Gentile C, Gebara M, Corden JL. 1996. The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins. Proc Natl Acad Sci USA 93:6975-6980.
45. Zahler AM, Lane WS, Stolk JA, Roth MB. 1992. SR proteins: A conserved family of pre-mRNA splicing factors. Genes & Dev 6:837-847.
46. Zhang WJ, Wu JY. 1996. Functional properties of p54, a novel SR protein active in constitutive and alternative splicing. Mol Cell Biol 16:5400-5408.
47. Zhang WJ, Wu JY. 1998. Sip1, a novel RS domain-containing protein essential for pre-mRNA splicing. Mol Cell Biol 18:676-684.