Effects of copper and ceruloplasmin on iron transport in the Caco 2 cell intestinal model

Journal of Nutritional Biochemistry

Volumn 13, Issue 3, 2002, Pages 138-148

  Zerounian, Nora R ^a   Linder, Maria C ^a  

^a CALIFORNIA STATE UNIVERSITY   (United States)

Author keywords

Caco 2 cells; Ceruloplasmin; Copper; Iron absorption; Iron transport; Iron uptake

Indexed keywords

APOTRANSFERRIN; ASCORBIC ACID; CERULOPLASMIN; COPPER PROTEIN; DEFEROXAMINE; IRON;

ABSORPTION; ARTICLE; BASOLATERAL MEMBRANE; CELL STRAIN CACO 2; CELL SURFACE; CONTROLLED STUDY; COPPER DEFICIENCY; HUMAN; HUMAN CELL; INTESTINE; INTESTINE ABSORPTION; IRON ABSORPTION; IRON KINETICS; IRON TRANSPORT; MODEL; PROTEIN BINDING; PROTEIN BLOOD LEVEL;

EID: 0036124399     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-2863(01)00205-4     Document Type: Article

References (73)

1. Ferritin in intestinal iron absorption: Effect of pancreatic duct ligation and role of free iron
2. The mechanism of iron absorption and its regulation
3. Investigation of a role for reduction in ferric iron uptake by mouse duodenum
4. Intestinal iron absorption: Current concepts circa 2000
5. Iron absorption and transport - An update
6. Intestinal metal ion absorption: An update
7. Reduction of Fe(III) is required for uptake of nonheme iron by Caco2 cells
8. Role of redox systems on Fe3+ uptake by transformed human intestinal epithelial (Caco-2) cells
9. Iron transport
10. Characterization and partial purification of a ferrireductase from human duodenal microvillus membrane
11. An iron-regulated ferric reductase associated with the absorption of dietary iron
12. A ferric reductase activity is found in the brush order membrane vesicles isolated from Caco2 cells
13. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
14. Cloning and characterization of a mammalian proton-coupled metal-ion transporter
15. Identification and characterization of a second mouse Nramp gene
16. Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport
17. Localization of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload
18. The human Nramp2 gene: Characterization of the gene structure, alternative splicing, promoter region and polymorphisms
19. Dietary iron induces rapid changes in rat intestinal divalent metal transporter expression
20. Iron: Molecular regulation and viability
21. Iron-dependent regulation of ferritin and transferrin receptor expression by the iron-responsive element binding protein
22. Iron homeostasis: New tales from the crypt
23. Toxicity associated with iron overload found in hemochromatosis: Possible mechanism in a rat model
24. Iron excretion in iron-overloaded rats following the change from an iron-loaded to an iron-deficient diet
25. Positional cloning of zebrafish ferroportin identifies a conserved vertebrate iron exporter
26. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
27. Regulation of iron uptake and transport by transferrin in Caco-2 cells, an intestinal epithelial cell line
28. Apotransferrin and holotransferrin undergo different endocytic cycles in intestinal epithelia (Caco-2) cells
29. The effect of apotransferrin on iron release from Caco-2 cells, an intestinal epithelial cell line
30. Gene expression of divalent metal transporter 1 and transferrin receptor in duodenum of Belgrade rats
31. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is detective in the sla mouse
32. A novel MHC class-I-like gene is mutated in patients with hereditary haemochromatosis
33. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding
34. Association of HFE protein with transferrin receptor in crypt enterocytes of human duodenum
35. The iron-copper connection: The link to ceruloplasmin grows
36. Interactions between copper and iron in mammalian metabolism
37. Failure of iron injection to reverse copper-dependent anemia in mice
38. Identification of an apoceruloplasmin-like substance in the plasma of copper-deficient rats
39. The nature of the copper centers in human ceruloplasmin
40. Distribution of copper among components of human serum
41. Copper transport in mammals
42. Ceruloplasmin, a link between copper and iron metabolism
43. Mobilization of liver iron by ferroxidase (ceruloplasmin)
44. Effect of ceruloplasmin on plasma iron in copper deficient swine
45. The role of ceruloplasmin in iron metabolism
46. A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans
47. Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux
48. The valency state of absorbed iron appearing in the portal blood and ceruloplasmin substitution
49. Studies on copper metabolism IV. The influence of copper on the absorption of iron
50. Iron metabolism in copper-deficient swine
51. Effects of iron on copper metabolism and copper on iron metabolism in rats
52. Hepatic iron accumulation in copper-deficient rats
53. Relation of ferroxidase (ceruloplasmin) to iron absorption
54. Studies on the roles of apotransferrin and ceruloplasmin (EC 1.16.3.1) on iron absorption in copper-deficient rats using isolated vascularly and luminally perfused intestinal preparation
55. The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake
56. The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake
57. Identification of a novel gene implicated in intestinal iron uptake and its defect in the SLA mouse
58. Caco-2 cell line: A system for studying intestinal iron transport across epithelial cell monolayers
59. Ceruloplasmin is found in milk and amniotic fluid and may have a nutritional role
60. Determination of serum copper and iron in a single sample
61. The effect of ceruloplasmin on iron release from placental (BeWo) cells; evidence for an endogenous Cu oxidase
62. Effect of ascorbic acid intake on nonheme-iron absorption from a complete diet
63. Ascorbate offsets the inhibitory effect of inositol phosphates on iron uptake and transport by Caco-2 cells
64. Iron absorption by CaCo2 cells cultivated in serum-free medium as in vitro model of the human intestinal epithelial barrier
65. Copper transport
66. The Menkes/Wilson disease gene homologue in yeast provides copper to a ceruloplasmin-like oxidase required for iron uptake
67. An oxidase-permease-based iron transport system in Schizosaccharomyces pombe and its expression in Saccharomyces cerevisiae
68. Iron metabolism in eukaryotes: Mars and venus at it again
69. Separate pathways for cellular uptake of ferric and ferrous iron
70. hCTR1: A human gene for copper uptake identified by complementation in yeast
71. Isolation of a murine copper transporter gene, tissue specific expression and functional complementation of a yeast copper transport mutant
72. Functional and molecular responses of human intestinal Caco-2 cells to iron treatment