Intestinal iron absorption: Current concepts circa 2000

Digestive and Liver Disease

Volumn 32, Issue 1, 2000, Pages 56-61

  Andrews, N C ^a,b,c  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Divalent metal transporter 1; DMT 1; Haemochromatosis; Iron; Iron absorption

Indexed keywords

HEMOGLOBIN; IRON;

ERYTHROCYTE; HOMEOSTASIS; HUMAN; INTESTINE ABSORPTION; IRON ABSORPTION; IRON TRANSPORT; MAMMAL CELL; MOLECULAR DYNAMICS; MOUSE; NONHUMAN; PLACENTA; RAT; REVIEW; SMALL INTESTINE;

EID: 0034069543     PISSN: 11258055     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1590-8658(00)80045-6     Document Type: Review

References (44)

1. London I. Iron and heme: crucial carriers and catalysts. In: Wintrobe MM, editor. Blood, pure and eloquent. New York: McGraw-Hill; 1980.
2. Looker AC, Dallman PR, Carroll MD, Gunter EW, Johnson CL. Prevalence of iron deficiency in the United States. J Am Med Assn 1997;277:973-6.
3. Hallberg L. Bioavailability of dietary iron in man. Annu Rev Nutr 1981;1:123-47.
4. Charlton RW, Bothwell TH. Iron absorption. Annu Rev Med 1983;34:55-68.
5. Muir A, Hopfer U. Regional specificity of iron uptake by small intestinal brush-border membranes from normal and iron-deficient mice. Am J Physiol 1985;11:G376-9.
6. Riedel HD, Remus AJ, Fitscher BA, Stremmel W. Characterization and partial purification of a ferrireductase from human duodenal microvillus membranes. Biochem J 1995;309:745-8.
7. Gorman JE, Clydesdale CM. The behavior and stability of iron-ascorbate complexes in solution. J Food Sci 1983;48:1217-25.
8. Dorey C, Cooper C, Dickson DPE, Gibson J, Simpson RJ, Peters TJ. Iron speciation at physiological pH in media containing ascorbate and oxygen. Br J Nutr 1993;70:157-69.
9. Edwards JA, Hoke JE. Defect of intestinal mucosal iron uptake in mice with hereditary microcytic anemia. Proc Soc Exp Biol Med 1972;141:81-4.
10. Manis J. Active transport of iron by intestine: selective genetic defect in the mouse. Nature 1970;227:385-6.
11. Edwards JA, Bannerman RM. Hereditary defect of intestinal iron transport in mice with sex-linked anemia. J Clin Invest 1970;49:1869-71.
12. Edwards JA, Hoke JE, Mattioli M, Reichlin M. Ferritin distribution and synthesis in sex-linked anemia. J Lab Clin Med 1977;90:68-76.
13. Fleming MD, Trenor CCI, Su MA, Foernzler D, Beier DR, Dietrich WF, et al. Microcytic anemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet 1997;16:383-6.
14. Gunshin H, Mackenzie B, Berger UV, Gunshin Y, Romero MF, Boron WF, et al. Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 1997;388:482-8.
15. Su MA, Trenor CC, Fleming JC, Fleming MD, Andrews NC. The G185R mutation disrupts function of iron transporter Nramp2. Blood 1998;92:2157-63.
16. Fleming RE, Migas MC, Zhou X, Jiang J, Britton RS, Brunt EM. et al. Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: increased duodenal expression of the iron transporter DMT1. Proc Natl Acad Sci USA 1999;96:3143-8.
17. Klausner RD, Rouault TA, Harford JB. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell 1993;72:19-26.
18. Fleming MD, Romano MA, Su MA, Garrick LM, Garrick MD, Andews NC. Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci USA 1998;95:1148-53.
19. Gruenheid S, Canonne-Hergaux F, Gauthier S, Hackam DJ, Grinstein S, Gros P. The iron transport protein NRAMP2 is a integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes. J Exp Med 1999;189:831-41.
20. Vulpe CD, Kuo YM, Murphy TL, Cowley L, Askwith C, Libina N, et al. Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse. Nat Genet 1999;21:195-9.
21. Stearman R, Yuan DS, Yamafuchi-Iwai Y, Klausner RD, Dancis A. A permease-oxidase complex involved in high-affinity iron uptake in yeast. Science 1996;271:1552-7.
22. Dancis A, Yuan DS, Haile D, Askwith C, Eide D, Moehle C, et al. Molecular characterization of a copper transport protein in S. cerevisiae: an unexpected role for copper in iron transport. Cell 1994;76:393-402.
23. McKie AT, Wehr K, Simpson RJ, Peters TJ, Hentze MW, Farzaneth F. Molecular cloning and characterisation of a novel duodenal-specific gene implicated in iron absorption. Biochem Soc Trans 1998;26:8264-9.
24. Hentze MW, Caughman SW, Rouault TA, Barriocanal JG, Dancis A, Harford JB, et al. Identification of the iron-responsive element of the translational regulation of human ferritin mRNA. Science 1987;238:1570-4.
25. Cook JD, Skikne B, Lynch SR, Reusser ME. Estimates of iron sufficiency in the US population. Blood 1986;68:726-31.
26. Bothwell TH, Pirsio-Biroli G, Finch CA. Iron absorption: I. Factors influencing absorption. J Lab Clin Med 1958;51:24-32.
27. Savin MA, Cook JD. Mucosal iron transport by rat intestine. Blood 1980;56:1029-35.
28. Pirzio-Beroli G, Finch CA, Loen B. Iron absorption: III. The influence of iron stores on iron absorption in the normal subject. J Lab Clin Med 1960;55:216-23.
29. Bezwoda WR, Bothwell TH, Charlton RW, Torrance JD, MacPhail AP, Derman DP, et al. The relative importance of haeme and non-haeme iron. S Afr Med J 1983;64:552-6.
30. Finch C. Regulators of iron balance in humans. Blood 1994;84:1697-702.
31. Solomon LR, Hillman RS, Finch CA. Serum ferritin in refractory anaemias. Acta Haematol 1981;661:1-5.
32. Schiffer LM, Brann I, Cronkite EP, Reizenstein P. Iron absorption and excretion in aregenerative anaemia. Acta Haematol 1966;35:80-90.
33. Pootrakul P, Kitcharoen K, Yansukon P, Wasi P, Fucharoen S, Charoenlarp P, et al. The effect of erythroid hyperplasia on iron balance. Blood 1988;71:1124-9.
34. Finch CA, Huebers H, Eng M, Miller L. Effect of transfused reticulocytes on iron exchange. Blood 1982;59:364-9.
35. Cook JD, Skikne BS, Baynes RD. Serum transferrin receptor. Ann Rev Med 1993;44:63-74.
36. Khumalo H, Gomo ZAR, Moyo VM, Gordeuk VR, Saungweme T, Rouault TA, et al. Serum transferrin receptors are decreased in the presence of iron overload. Clin Chem 1998;44:40-4.
37. Feder JN, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy DA, Basava A, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet 1996;13:399-408.
38. Lebron JA, Bennett MJ, Vaughn DE, Chirino AJ, Snow PM, Mintier GA, et al. Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Cell 1998;93:111-23.
39. Parkkila S, Waheed A, Britton RS, Bacon BR, Zhou XY, Tomatsu S, et al. Association of the transferrin receptor in human placenta with HFE, the protein defective in hereditary hemochromatosis. Proc Natl Acad Sci USA 1997;94:13198-203.
40. Feder JN, Penny DM, Irrinki A, Lee VK, Lebron JA, Watson N, et al. The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding. Proc Natl Acad Sci USA 1998;95:1472-7.
41. Powell LW, Campbell CB, Wilson E. Intestinal mucosal uptake of iron and iron retention in idiopathic haemochromatosis as evidence for a mucosal abnormality. Gut 1970;11:727-31.
42. Mc Laren GD, Nathanson MH, Jacobs A, Trevett D, Thomson W. Regulation of intestinal iron absorption and mucosal iron kinetics in hereditary hemochromatosis. J Lab Clin Med 1991;117:390-401.
43. Pietrangelo A, Rocchi E, Casalgrandi G, Rigo G, Ferrari A, Perini M, et al. Regulation of transferrin, transferrin receptor and ferritin genes in human duodenum. Gastroenterology 1992;102:802-9.
44. Vulpe C, Levinson B, Whitney S, Packman S, Gitschier J. Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase. Nat Genet 1993;3:7-13.