Differential expression of the retinoblastoma gene family members pRb/p105, p107, and pRb2/p130 in lung cancer

Clinical Cancer Research

Volumn 2, Issue 7, 1996, Pages 1239-1245

  Baldi, Alfonso ^a,c   Esposito, Vincenzo ^b   De Luca, Antonio ^a   Howard, Candace M ^a   Mazzarella, Gennaro ^b   Baldi, Feliciano ^b   Caputi, Mario ^b   Giordano, Antonio ^a,d  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b SECOND UNIVERSITY OF NAPLES   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CARCINOGENICITY; CELL PROLIFERATION; GENE EXPRESSION; GENETIC REGULATION; GROWTH REGULATION; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; LUNG CANCER; MOLECULAR INTERACTION; MULTIGENE FAMILY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; TUMOR SUPPRESSOR GENE;

ANIMALS; HUMANS; IMMUNOHISTOCHEMISTRY; LUNG NEOPLASMS; NUCLEAR PROTEINS; PHOSPHOPROTEINS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEINS; RABBITS; RETINOBLASTOMA PROTEIN; RETINOBLASTOMA-LIKE PROTEIN P107; RETINOBLASTOMA-LIKE PROTEIN P130;

EID: 0029903054     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (45)

1. Knudson, A. G. Mutation and cancer: statistical study of retinoblastoma. Proc Natl. Acad. Sci. USA, 68: 820-823, 1971.
2. Knudson, A. G. Hereditary cancers disclose a class of cancer genes. Cancer, 63: 1888-1891, 1989.
3. Sang, N., Baldi, A., and Giordano, A. The roles of tumor suppressors pRb and p53 in cell proliferation and cancer. Mol. Cell. Differ., 3: 1-29, 1995.
4. De Luca, A., Baldi, A., Claudio, P. P., Howard, C. M., Campisi, S., Giordano, A., and Condorelli, G. The retinoblastoma gene and its role in cancer and differentiation. Front. Endocrinol., 14: 197-206, 1995.
5. Bookstein, R., Shew, J. Y., Chen, B L , Scully, B., and Lee, W. H. Suppression of tumorigenicity of human prostate carcinoma cells by replacing a mutated RB gene. Science (Washington DC), 247: 712-715, 1990.
6. Cheng, J., Scully, P., Shew, J. Y., Lee, W. H., and Haas, M. Homozygous deletion of the retinoblastoma gene in an acute lymphoblastic leukemia (T) cell line. Blood, 75: 730-735, 1990.
7. Uzvolgyi, E., Classon, M., Henriksson, M., Huang, H. J., Szekely, L., Lee, W. H., Klein, G., and Sumnegi, J. Reintroduction of a normal retinoblastoma gene into retinoblastoma and osteosarcoma cells inhibits the replication-associated function of SV40 large T antigen. Cell Growth & Differ., 2: 297-303, 1991.
8. Chellapan, S. P., Hiebert, S., Mudryj, M., Horowitz, J. M., and Nevins, J. R. The E2F transcription factor is a cellular target for the RB protein. Cell, 65: 1053-1061, 1991.
9. Hiebert, S. W., Chellapan, S P., Horowitz, J M., and Nevins, J. R. The interaction of RB with E2F coincides with an inhibition of the transcriptional activity of E2F. Genes Dev., 6: 177-185, 1992.
10. Chen, P. L., Scully, P., Shew, J. Y., Wang, J. Y. J., and Lee, W. H. Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation. Cell, 58, 1193-1198, 1989.
11. De Capno, J. A., Furukawa, Y., Ajchenbaum, F., Griffin, J. D., and Livingston, D. M. The retinoblastoma-susceptibility gene product becomes phosphorylated in multiple stages during cell cycle entry and progression. Proc. Natl. Acad. Sci. USA, 89: 1795-1798, 1992
12. De Caprio, J. A., Ludlow, J. W., Figge, J., Shew, J. Y., Huang, C. M., Lee, W. H., Marsilio, E., Paucha, E., and Livingston, D. M. SV40 large tumor antigen forms a specific complex with the product of the retonoblastoma susceptibility gene Cell, 54, 275-283, 1988.
13. Dyson, N., Howley, P. M., Muenger, K , and Harlow, E. The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product. Science (Washington DC), 243: 934-937, 1989.
14. Whyte, P., Buchkovich, K. J , Horowitz, J. M., Friend, S. H., Raybuck, M., Weinberg, R. A., and Harlow, E. Association between an oncogene and an anti-oncogene: the adenovirus E1A proteins bind to the retinoblastoma gene product. Nature (Lond.), 334: 124-129, 1988.
15. Ewen, M. E., Xing, Y., Lawrence, J. B., and Livingston, D. M. Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein. Cell, 66: 1155-1164, 1991.
16. Mayol, X., Grana, X., Baldi, A., Sang, N., Hu, Q., and Giordano, A. Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain. Oncogene, 8: 2561-2566, 1993.
17. Li, Y., Graham, C., Lacy, S., Duncan, A. M., and Whyte, P. The adenovirus E1A-associated 130-kDa protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclin A and E. Genes Dev., 7: 2366-2377, 1993.
18. Hannon, G. J., Demetrick, D., and Beach, D. Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins. Genes Dev., 7: 2378-2391, 1993.
19. 1 phase of the cell cycle. Cell, 67: 293-302, 1991.
20. Zhu, L., Van den Heuvel, S., Helin, K., Fattaey, A., Ewen, M., Livingston, D. M., Dyson, N., and Harlow, E. Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein. Genes Dev., 7, 1111-1125, 1993.
21. Claudio, P. P., Howard, C. M., Baldi, A., De Luca, A., Fu, Y., Condorelli, G , Sun, Y., Colburn, N., Calabretta, B., and Giordano, A. pRb2/p130 has growth-suppressive properties similar to yet distinctive from those of retinoblastoma family members pRb and p107. Cancer Res., 54: 5556-5560, 1994.
22. Zhu, L., Enders, G., Lees, J. A., Beijersbergen, R. L., Bernards, R., and Harlow, E. The pRB-related protein p107 contains two growth suppression domains: independent interactions with E2F and cyclin/cdk complexes. EMBO J., 14: 1904-1913, 1995
23. 1 cyclin complexes. Genes Dev., 9: 1340-1353, 1993
24. Claudio, P. P., De Luca, A., Howard, C. M., Baldi, A , Firpo, E. J., Koff, A., Paggi, M. G., and Giordano, A. Functional analysis of pRb2/ p130 interaction with cyclins. Cancer Res., 56: 2003-2008, 1996.
25. Baldi, A., De Luca, A., Claudio, P. P., Baldi, F., Giordano, G. G., Tommasino, M , Paggi, M. G., and Giordano, A. The Rb2/p130 gene product is a nuclear protein whose phosphorylation is cell cycle regulated. J. Cell. Biochem., 59: 402-408, 1995.
26. Shirodkar, S., Ewen, M., De Capno, J. A., Morgan, J., Livingston, D. M., and Chitteden, T. The transcription factor E2F interacts with the retinoblastoma product and a p107-cyclin A complex in a cell cycle-regulated manner. Cell, 66, 157-166, 1992.
27. Cobrinik, D., Whyte, P., Peeper, D. S., Jacks, T., and Weinberg, R. A. Cell cycle-specific association of E2F with the p130 E1A-binding protein. Genes Dev., 7: 2392-2404, 1993.
28. Hijmans, E. M., Voorhoeve, P. M., Beijersbergen, R. L., Van'T Veer, L. J., and Bernards, R E2F-5, a new E2F family member that interacts with p130 in vivo. Mol. Cell. Biol., 15: 3082-3089, 1995.
29. Vairo, G., Livingston, D M., and Ginsberg, D. Functional interaction between E2F-4 and p130: evidence for distinct mechanisms underlying growth suppression by different retinoblastoma protein family members. Genes Dev., 9: 869-881, 1995.
30. Boring, C. C., Squires, T. S., and Tong, T. Cancer statistics. Cancer J. Clin., 43: 7-26, 1993.
31. Yokota, J., Akiyama, T., Fung, Y-K. T., Benedict, W. F , Namba, Y., Hanaoka, M., Wada, M., Terasaki, T., Shimosato, Y., Sugimura, T., and Terada. M. Altered expression of the retinoblastoma (RB) gene in small cell carcinoma of the lung. Oncogene, 3: 471-475, 1988.
32. Harbour, J. W., Lai, S. L., Whang-Peng, J., Gadzar, A. F., Minna, J. D., and Kaye, F. J. Abnormalities in structure and expression of the human retinoblastoma gene in SCLC. Science (Washington DC), 241: 353-357, 1988.
33. Xu, H. J., Hu, S. X., Cagle, P. T., Moore, G. E., and Benedict W. F. Absence of retinoblastoma protein expression in primary non-small cell lung carcinomas. Cancer Res., 57: 2735-2739, 1991.
34. Xu, H. J., Quinlan, D. C., Davidson, A. G., Hu, S. X., Summers, C. L., Li, J , and Benedict, W. F. Altered retinoblastoma protein expression and prognosis in early-stage non-small cell lung carcinoma. J. Natl. Cancer Inst., 86: 695-699, 1994.
35. Higashiyama, M., Doi, O., Kodama, K., Yokouchi, H., and Tateishi, R. Retinoblastoma protein expression in lung cancer: an immunohistochemical analysis. Oncology (Basel), 51: 544-551, 1994.
36. Hall, P. A., Levinson, D. A., Woods, A. L., Yu, C. W., Kellock, D. B., Watkins, J. A., Barnes, D. M., Gillet, C. E., Camplejohn, R., Dover, R., Waseem, N. H., and Lane, D. P. Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with the evidence of deregulated expression in some neoplasms. J. Pathol., 162: 285-294, 1990.
37. Giordano, A., Lee, J. H., Schepper, J. A., Herrmann, C., Harlow, E., Deuschle, U., Beach, D., and Franza, B. R. Cell cycle regulation of histone H1 kinase activity associated with adenovirus protein E1A. Science (Washington DC), 253: 1271-1275, 1991.
38. Hu, Q., Bautista, C., Edwards, G. M., Defeo-Jones, D., Jones, R., and Harlow, E. Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides. Mol. Cell. Biol., 11: 5792-5799, 1991.
39. Smith, D B, and Johnson, K. S. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene (Amst.), 67: 31-40, 1988.
40. Frangioni, J. V., and Neel, B. G. Solubilization and purification of enzymatically active glutathione S-transferase (pGEX) fusion proteins. Anal. Biochem., 270, 179-187, 1993
41. Mountain, C. F. A new international staging system for lung cancer. Chest, 89: 225-233, 1986.
42. Zalvide, J., and DeCaprio, J. A. Role of pRb-related proteins in simian virus 40 large T antigen-mediated transformation. Mol Cell. Biol., 75: 5800-5810, 1995.
43. Korkolopoulou, P., Oates, J., Crocker, J., and Edwards, G. p53 expression in oat and non-oat small cell lung carcinomas: correlation with proliferating cell nuclear antigen. J Clin. Pathol. (Lond.), 46: 1093-1096, 1993.
44. Ramael, M., Jacobs, W., Wejler, J., Van Meerbeck, J., Bialasiewicz, P., Van De Bossche, J., Buysse, C., Vermeire, P., and Van Marck, E. Proliferation in malignant mesothelioma determined by mitosis count and immunoreactivity for proliferating cell nuclear antigen (PCNA). J. Pathol., 172: 247-253, 1994.
45. Baldi, A., Boccia, V., Claudio, P P., De Luca, A., and Giordano, A. Genomic structure of the human retinoblastoma-related Rb2/p130 gene. Proc. Natl. Acad. Sci. USA, 93: 4629-4632, 1996.