Hepatic transport systems

Journal of Gastroenterology and Hepatology (Australia)

Volumn 17, Issue SUPPL. 1, 2002, Pages

  Ferenci, Peter ^a,c   Zollner, Gernot ^b   Trauner, Michael ^b  

^a UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF GRAZ   (Austria)

^c Div of Gastroenterol and Hepatol   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATE; BILE SALT; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 7; CARRIER PROTEIN; CERULOPLASMIN; COPPER; CYTOCHROME C OXIDASE; DOPAMINE BETA MONOOXYGENASE; PROTEIN LYSINE 6 OXIDASE;

ALZHEIMER DISEASE; BILE SECRETION; CHOLESTASIS; CONFERENCE PAPER; COPPER METABOLISM; CYSTIC FIBROSIS; DEGENERATIVE DISEASE; DUBIN JOHNSON SYNDROME; HUMAN; INTRAHEPATIC CHOLESTASIS; LIVER CELL; MENKES SYNDROME; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; WILSON DISEASE;

EID: 0036111771     PISSN: 08159319     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1746.17.s1.15.x     Document Type: Conference Paper

References (85)

1. Nathanson: Bile formation
2. Regulation of cholangiocyte bile secretion
3. Molecular aspects of hepatobiliary transport
4. The secretory function of the liver: New aspects of hepatobiliary transport
5. Molecular pathogenesis of cholestasis
6. Hepatobiliary transport
7. Molecular regulation of hepatocellular transport systems in cholestasis
8. Expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system
9. Molecular cloning, chromosomal localization, and functional characterization of a human Na+/bile acid cotransporter
10. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
11. Regulation of organic anion and drug transporters of the sinusoidal membrane
12. Expression cloning and characterization of the hamster sodium-dependent bile acid transporter
13. Dawson. Identification of a mutation in the ileal sodium-dependent bile acid transporter gene that abolishes transport activity
14. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1
15. A novel human hepatic organic anion transporting polypeptide (OATP2) - Identification of a liver specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters
16. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane
17. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide
18. Introduction: Transport across the hepatocyte canalicular membrane
19. The human multidrug resistance (mdr1) gene. cDNA cloning and transcription initiation
20. Regulation and function of the multidrug resistance genes in liver
21. Sequence of mdr3 cDNA encoding a human P-glycoprotein
22. Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to complete absence of phospholipids from bile and to liver disease
23. Identification of a scavenger receptor SR-BI as a high density lipoprotein receptor
24. Overexpression of the HDL receptor SR-BI alters plasma HDL and bile cholesterol levels
25. Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile
26. cDNA cloning of the hepatocyte canalicular isoform of the multidrug resistance protein, cMrp, reveals a novel conjugate export pump deficient in hyperbilirubinemic mutant rats
27. Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
28. The role of the canalicular multispecific organic anion transporter in the disposal of endo- and xenobiotics
29. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane
30. MRP3, an organic anion transporter able to transport-anti cancer drugs
31. Characterization of inducible nature of MRP3 in rat liver
32. The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver
33. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis
34. Targeted inactivation of sister of P-glycoprotein gene (SPGP) in mice results in non-progressive but persistent intrahepatic cholestasis
35. A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis
36. Cracking the genetic code for benign recurrent and progressive familial intrahepatic cholestasis
37. Immunohistochemical detection of chloride/bicarbonate anion exchangers in human liver
38. Localization of the cystic fibrosis transmembrane conductance regulator in human bile duct epithelial cells
39. Functional expression of the apical Na+-dependent bile acid transporter in large but not small rat cholangiocytes
40. Rat cholangiocytes absorb bile acids at their apical domain via the ileal sodium-dependent bile acid transporter
41. New genetics of inheritable jaundice and cholestatic liver disease
42. Progressive familial intrahepatic cholestasis types 1, 2, and 3
43. The molecular genetics of familial intrahepatic cholestasis
44. A missense mutation in FIC1 is associated with Greenland familial cholestasis
45. Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis
46. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis
47. Class III P-glycoproteins mediate the formation of lipoprotein X in the mouse
48. Expression of cystic fibrosis transmembrane conductance regulator in liver tissue from patients with cystic fibrosis
49. The diagnosis of cystic fibrosis: A consensus statement
50. Heterozygous non-sense mutation of the MDR3-gene in familial intrahepatic cholestasis of pregnancy
51. Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (BSEP) of rat liver
52. A delicate balance. Homeostatic control of copper uptake and distribution
53. Copper transport and its alterations in Menkes and Wilson's diseases
54. Genetic disorders of membrane transport. IV. Wilson's disease and Menkes disease
55. Iron and copper transport in yeast and its relevance to human disease
56. Intracellular copper routing. The role of copper chaperones
57. Cellular copper transport
58. Intracellular pathways of copper trafficking in yeast and humans
59. Metal ion chaperone function of the soluble Cu (I) receptor Atx1
60. Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis
61. The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake
62. The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis
63. Aceruloplasminemia: Molecular characterization of this disorder of iron metabolism
64. The iron-copper connection: The link to ceruloplasmin grows stronger
65. The copper chaperone CCS directly interacts with copper/zinc superoxide dismutase
66. Characterization of COX17, a yeast gene involved in copper metabolism and assembly of cytochrome oxidase
67. Fatal infantile cardioencephalomyopathy with COX deficiency and mutations in SCO2, a COX assembly gene
68. Mutations of the SCO1 gene in mitochondrial cytochrome C oxidase deficiency with neonatal-onset hepatic failure and encephalopathy
69. Functional expression of the Wilson disease protein reveals mislocalization and impaired copper-dependent trafficking of the common H1069Q mutation
70. Copper transport and its defect in Wilson disease: Characterization of the copper-binding domain of Wilson disease ATPase
71. Very high frequency of the His1069Gln mutation in Polish Wilson disease patients
72. The His1069Gln mutation in Wilson's disease: Detection by a rapid PCR-test, clinical course, and liver biopsy findings
73. High Prevalence of the H1069Q mutation in East German patients with Wilson Disease. Rapid detection of mutations by limited sequencing and phenotype-genotype analysis
74. Common mutations of ATP7B in Wilson disease patients from Hungary
75. Processing of mutant cystic fibrosis transmembrane conductance regulator is temperature-sensitive
76. A mutation of the Wilson disease protein, ATP7B, is degraded in the proteasomes and forms protein aggregates
77. Copper-dependent trafficking of Wilson disease mutant ATP7B proteins
78. How does copper get into bile? New insights into the mechanism (s) of hepatobiliary copper transport
79. Mining copper transport genes
80. The amyloid precursor protein of Alzheimer's disease in the reduction of copper (II) to copper (I)
81. The cellular prion protein binds copper in vivo
82. Metals and neuroscience
83. Genetic heterogeneity in Wilson's disease: Lessons from rare alleles