Preexisting immunity to adenovirus in rhesus monkeys fails to prevent vector-induced toxicity

Journal of Virology

Volumn 76, Issue 11, 2002, Pages 5711-5719

  Varnavski, Andrei N ^a   Zhang, Yi ^a   Schnell, Michael ^a   Tazelaar, John ^a   Louboutin, Jean Pierre ^a   Yu, Qian Chun ^a   Bagg, Adam ^a   Gao, Guang Ping ^a   Wilson, James M ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIGEN PRESENTING CELL; ARTICLE; BLOOD CLOTTING DISORDER; BONE MARROW; CELLULAR IMMUNITY; CLINICAL FEATURE; CONTROLLED STUDY; ERYTHROID PRECURSOR CELL; GENE DELETION; GENE EXPRESSION; GENE TRANSFER; IMMUNE RESPONSE; IMMUNIZATION; INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; TOXICITY; TRANSGENE; VIRUS IMMUNITY;

ADENOVIRUSES, HUMAN; ANIMALS; ANTIBODIES, VIRAL; BONE MARROW CELLS; CELL COUNT; ERYTHROID PROGENITOR CELLS; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HELA CELLS; HUMANS; IMMUNIZATION; INTERLEUKIN-6; MACACA MULATTA; TRANSGENES;

EID: 0036091867     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.76.11.5711-5719.2002     Document Type: Article

References (40)

1. Immediate inflammatory responses to adenovirus-mediated gene transfer in rat salivary glands
2. Acute responses of non-human primates to airway delivery of an adenovirus vector containing the human cystic fibrosis transmembrane conductance regulator cDNA
3. CD56 identifies monocytes and not natural killer cells in rhesus macaques
4. Immune responses to adenovirus and adeno-associated virus in humans
5. Modulation of the inflammatory properties and hepatotoxicity of recombinant adenovirus vectors by the viral E4 gene products
6. "Stealth" adenoviruses blunt cell-mediated and humoral immune responses against the virus and allow for significant gene expression upon readministration in the lung
7. Transfer of genes to humans: Early lessons and obstacles to success
8. Administration of an adenovirus containing the human CFTR cDNA to the respiratory tract of individuals with cystic fibrosis
9. Intra-CSF administered recombinant adenovirus causes an immune response-mediated toxicity
10. Toxicity of replication-defective adenoviral recombinants in dissociated cultures of nervous tissue
11. Replication-defective vector based on a chimpanzee adenovirus
12. The distinct surface of human blood dendritic cells, as observed after an improved isolation method
13. Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy
14. Adenovirus vectors for gene therapy
15. Cytotoxic T-lymphocyte target proteins and their major histocompatibility complex class I restriction in response to adenovirus vectors delivered to mouse liver
16. Long-term humoral and cellular immunity induced by a single immunization with replication-defective adenovirus recombinant vector
17. Circumventing the immune response to adenovirus-mediated gene therapy
18. The cluster of differentiation (CD) antigens
19. Assessment of recombinant adenoviral vectors for hepatic gene therapy
20. Circumvention of anti-adenovirus neutralizing immunity by administration of an adenoviral vector of an alternate serotype
21. Adenoviral gene therapy leads to rapid induction of multiple chemokines and acute neutrophil-dependent hepatic injury in vivo
22. Human marrow stromal cells: Response to interleukin-6 (IL-6) and control of IL-6 expression
23. Gene transfer into the liver of nonhuman primates with El-deleted recombinant adenoviral vectors: Safety of readministration
24. Nonspecific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses
25. Adenovirus-mediated hepatic gene transfer in mice: Comparison of intravascular and biliary administration
26. Successful interference with cellular immune responses to immunogenic proteins encoded by recombinant viral vectors
27. Activation of innate immunity in nonhuman primates following intraportal administration of adenoviral vectors
28. Disseminated intravascular coagulation
29. Dendritic cells in the T-cell areas of lymphoid organs
30. Inhibition of immature erythroid progenitor cell proliferation by macrophage inflammatory protein-1α by interacting mainly with a C-C chemokine receptor, CCRI
31. Liver-directed gene transfer in non-human primates
32. Acute direct adenoviral vector cytotoxicity and chronic, but not acute, inflammatory responses correlate with decreased vector-mediated transgene expression in the brain
33. Safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lungs of nonhuman primates
34. Innate immune mechanisms dominate elimination of adenoviral vectors following in vivo administration
35. Immunology of gene therapy with adenoviral vectors in mouse skeletal muscle
36. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
37. Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages
38. + dendritic cells
39. Human blood dendritic cells selectively express CD83, a member of the immunoglobulin superfamily
40. Internalization of adenovirus by alveolar macrophages initiates early proinflammatory signaling during acute respiratory tract infection