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Volumn 11, Issue 3, 2000, Pages 415-427

Modulation of the inflammatory properties and hepatotoxicity of recombinant adenovirus vectors by the viral E4 gene products

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; COMPLEMENTARY DNA; GENE PRODUCT; VIRUS DNA; VIRUS VECTOR;

EID: 0034628484     PISSN: 10430342     EISSN: None     Source Type: Journal    
DOI: 10.1089/10430340050015888     Document Type: Article
Times cited : (70)

References (58)
  • 3
    • 0028914687 scopus 로고
    • Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: Comparisons between immunocompetent and immunodeficient inbred strains
    • BARR, D., TUBB, J., FERGUSSON, D., SCARIA, A., LIEBER, A., WILSON, C., PERKINS, J., and KAY, M.A. (1995). Strain related variations in adenovirally mediated transgene expression from mouse hepatocytes in vivo: Comparisons between immunocompetent and immunodeficient inbred strains. Gene Ther. 2, 151-155.
    • (1995) Gene Ther. , vol.2 , pp. 151-155
    • Barr, D.1    Tubb, J.2    Fergusson, D.3    Scaria, A.4    Lieber, A.5    Wilson, C.6    Perkins, J.7    Kay, M.A.8
  • 5
    • 0023764622 scopus 로고
    • Development of adenovirus vectors for the expression of heterologous genes
    • BERKNER, K.L. (1988). Development of adenovirus vectors for the expression of heterologous genes. BioTechniques 6, 616-629.
    • (1988) BioTechniques , vol.6 , pp. 616-629
    • Berkner, K.L.1
  • 6
    • 0030730116 scopus 로고    scopus 로고
    • Prospect for adenovirus-mediated gene therapy of inherited diseases of the myocardium
    • BOWLES, N.E., and WANG, Q. (1997). Prospect for adenovirus-mediated gene therapy of inherited diseases of the myocardium. Cardiovasc. Res. 35, 422-430.
    • (1997) Cardiovasc. Res. , vol.35 , pp. 422-430
    • Bowles, N.E.1    Wang, Q.2
  • 7
    • 0024571586 scopus 로고
    • Redundant control of adenovirus late gene expression by early region 4
    • BRIDGE, E., and KETNER, G. (1989). Redundant control of adenovirus late gene expression by early region 4. J. Virol. 63, 631-638.
    • (1989) J. Virol. , vol.63 , pp. 631-638
    • Bridge, E.1    Ketner, G.2
  • 8
  • 9
    • 0030728433 scopus 로고    scopus 로고
    • Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo
    • BROUGH, D.E., HSU, C., KULESA, V.A., LEE, G.M., CANTOLUPO, L.J., LIZONOVA, A., and KOVESDI, I. (1997). Activation of transgene expression by early region 4 is responsible for a high level of persistent transgene expression from adenovirus vectors in vivo. J. Virol. 71, 9206-9213.
    • (1997) J. Virol. , vol.71 , pp. 9206-9213
    • Brough, D.E.1    Hsu, C.2    Kulesa, V.A.3    Lee, G.M.4    Cantolupo, L.J.5    Lizonova, A.6    Kovesdi, I.7
  • 10
    • 0019446161 scopus 로고
    • Deletion mutants of adenovirus 2: Isolation and initial characterization of virus carrying mutations near the right end of the viral genome
    • CHALLBERG, S.S., and KETNER, G. (1981). Deletion mutants of adenovirus 2: Isolation and initial characterization of virus carrying mutations near the right end of the viral genome. Virology 114, 196-209.
    • (1981) Virology , vol.114 , pp. 196-209
    • Challberg, S.S.1    Ketner, G.2
  • 11
    • 0029977774 scopus 로고    scopus 로고
    • Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli
    • CHARTIER, C, DEGRYSE, E., GANTZER, M., DIETERLE, A., PAVIRANI, A., and MEHTALI, M. (1996). Efficient generation of recombinant adenovirus vectors by homologous recombination in Escherichia coli. J. Virol. 70, 4805-4810.
    • (1996) J. Virol. , vol.70 , pp. 4805-4810
    • Chartier, C.1    Degryse, E.2    Gantzer, M.3    Dieterle, A.4    Pavirani, A.5    Mehtali, M.6
  • 13
    • 0026551721 scopus 로고
    • The sequence of the genome of adenovirus type 5 and its comparison with the genome of adenovirus type 2
    • CHROBOCZEK, J., BIEBER, F., and JACROT, B. (1992). The sequence of the genome of adenovirus type 5 and its comparison with the genome of adenovirus type 2. Virology 186, 280-285.
    • (1992) Virology , vol.186 , pp. 280-285
    • Chroboczek, J.1    Bieber, F.2    Jacrot, B.3
  • 15
    • 0031887537 scopus 로고    scopus 로고
    • High adenoviral loads stimulate NfκB-dependent gene expression in human vascular smooth muscle cells
    • CLESHAM, G.J., ADAM, P.J., PROUDFOOT, D., FLYNN, P.D., EFSTATHIOU, S., and WEISSBERG, P.L. (1998). High adenoviral loads stimulate NfκB-dependent gene expression in human vascular smooth muscle cells. Gene Ther. 5, 174-180.
    • (1998) Gene Ther. , vol.5 , pp. 174-180
    • Clesham, G.J.1    Adam, P.J.2    Proudfoot, D.3    Flynn, P.D.4    Efstathiou, S.5    Weissberg, P.L.6
  • 16
    • 0027193894 scopus 로고
    • Endothelial nuclear factor-κB and the initiation of the atherosclerotic lesion
    • COLLINS, T. (1993). Endothelial nuclear factor-κB and the initiation of the atherosclerotic lesion. Lab. Invest. 68, 499-508.
    • (1993) Lab. Invest. , vol.68 , pp. 499-508
    • Collins, T.1
  • 20
    • 0028246338 scopus 로고
    • Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver
    • ENGELHARDT, J.F., YE, X., DORANZ, B., and WILSON, J.M. (1994a). Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver. Proc. Natl. Acad. Sci. U.S.A. 91, 6196-6200.
    • (1994) Proc. Natl. Acad. Sci. U.S.A. , vol.91 , pp. 6196-6200
    • Engelhardt, J.F.1    Ye, X.2    Doranz, B.3    Wilson, J.M.4
  • 21
    • 0028618419 scopus 로고
    • Prolonged transgene expression in cotton rat lung with recombinant adenoviruses in E2a
    • ENGELHARDT, J.F., LITZKY, L., and WILSON, J.M. (1994b). Prolonged transgene expression in cotton rat lung with recombinant adenoviruses in E2a. Hum. Gene Ther. 5, 1217-1229.
    • (1994) Hum. Gene Ther. , vol.5 , pp. 1217-1229
    • Engelhardt, J.F.1    Litzky, L.2    Wilson, J.M.3
  • 24
    • 1842330292 scopus 로고    scopus 로고
    • Humoral immune response to the capsid components of recombinant adenoviruses: Routes of immunization modulate virus-induced Ig subclass shifts
    • GAHÉRY-SÉGARD, H., JUILLARD, V., GASTON, J., LENGAGNE, R., PAVIRANI, A., BOULANGER, P., and GUILLET, J.G. (1997a). Humoral immune response to the capsid components of recombinant adenoviruses: Routes of immunization modulate virus-induced Ig subclass shifts. Eur. J. Immunol. 27, 653-659.
    • (1997) Eur. J. Immunol. , vol.27 , pp. 653-659
    • Gahéry-Ségard, H.1    Juillard, V.2    Gaston, J.3    Lengagne, R.4    Pavirani, A.5    Boulanger, P.6    Guillet, J.G.7
  • 26
    • 0029959867 scopus 로고    scopus 로고
    • Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy
    • GAO, G.P., YANG, Y., and WILSON, J.M. (1996). Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy. J. Virol. 70, 8934-8943.
    • (1996) J. Virol. , vol.70 , pp. 8934-8943
    • Gao, G.P.1    Yang, Y.2    Wilson, J.M.3
  • 27
    • 0029664338 scopus 로고    scopus 로고
    • Elimination of both E1 and E2a from adenovirus vectors further improves prospects for in vivo human gene therapy
    • GORZIGLIA, M.I., KADAN, M.J., YEI, S., LIM, J., LEE, G.M., LUTHRA, R., and TRAPNELL, B.C. (1996). Elimination of both E1 and E2a from adenovirus vectors further improves prospects for in vivo human gene therapy. J. Virol. 70, 4173-4178.
    • (1996) J. Virol. , vol.70 , pp. 4173-4178
    • Gorziglia, M.I.1    Kadan, M.J.2    Yei, S.3    Lim, J.4    Lee, G.M.5    Luthra, R.6    Trapnell, B.C.7
  • 28
    • 0026484050 scopus 로고
    • Adenovirus based expression vectors and recombinant vaccines
    • R.W. Ellis, ed. (Butterworth-Heinemann, Newton, MA)
    • GRAHAM, F.L., and PREVEC, L. (1992). Adenovirus based expression vectors and recombinant vaccines. In: Vaccines: New Approaches to Immunological Problems. R.W. Ellis, ed. (Butterworth-Heinemann, Newton, MA) pp. 363-390.
    • (1992) Vaccines: New Approaches to Immunological Problems , pp. 363-390
    • Graham, F.L.1    Prevec, L.2
  • 29
    • 0017710978 scopus 로고
    • Characteristics of a human cell line transformed by DNA from human adenovirus type 5
    • GRAHAM, F.L., SMILEY, J., RUSSELL, W.C., and NAIRN, R. (1977). Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J. Gen. Virol. 36, 59-72.
    • (1977) J. Gen. Virol. , vol.36 , pp. 59-72
    • Graham, F.L.1    Smiley, J.2    Russell, W.C.3    Nairn, R.4
  • 30
    • 0024756945 scopus 로고
    • The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor E2F, through a direct complex
    • HUANG, M.-M., and HEARING, P. (1989). The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor E2F, through a direct complex. Genes Dev. 3, 1699-1710.
    • (1989) Genes Dev. , vol.3 , pp. 1699-1710
    • Huang, M.-M.1    Hearing, P.2
  • 31
    • 0028982479 scopus 로고
    • Trans-complementation of E1-deleted adenovirus: A new vector to reduce the possibility of codissemination of wild-type and recombinant adenoviruses
    • IMLER, J.L., BOUT, A., DREYER, D., DIETERLÉ, A., SCHULTZ, H., VALÉRIO, D., MEHTALI M., and PAVIRANI, A. (1995). Trans-complementation of E1-deleted adenovirus: A new vector to reduce the possibility of codissemination of wild-type and recombinant adenoviruses. Hum. Gene Ther. 6, 711-721.
    • (1995) Hum. Gene Ther. , vol.6 , pp. 711-721
    • Imler, J.L.1    Bout, A.2    Dreyer, D.3    Dieterlé, A.4    Schultz, H.5    Valério, D.6    Mehtali, M.7    Pavirani, A.8
  • 32
    • 0029560716 scopus 로고
    • Long-term humoral and cellular immunity induced by a single immunization with replication-defective adenovirus recombinant vector
    • JUILLARD, V., VILLEFROY, P., GODFRIN, D., PAVIRANI, A., VENET, A., and GUILLET, J.G. (1995). Long-term humoral and cellular immunity induced by a single immunization with replication-defective adenovirus recombinant vector. Eur. J. Virol. 25, 3467-3473.
    • (1995) Eur. J. Virol. , vol.25 , pp. 3467-3473
    • Juillard, V.1    Villefroy, P.2    Godfrin, D.3    Pavirani, A.4    Venet, A.5    Guillet, J.G.6
  • 33
    • 0032530110 scopus 로고    scopus 로고
    • Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: Implications for gene therapy
    • KAFRI, T., MORGAN, D., KRAHL, T., SARVETNICK, N., SHERMAN, L., and VERMA, I. (1998). Cellular immune response to adenoviral vector infected cells does not require de novo viral gene expression: Implications for gene therapy. Proc. Natl. Acad. Sci. U.S.A. 95, 11377-11382.
    • (1998) Proc. Natl. Acad. Sci. U.S.A. , vol.95 , pp. 11377-11382
    • Kafri, T.1    Morgan, D.2    Krahl, T.3    Sarvetnick, N.4    Sherman, L.5    Verma, I.6
  • 34
    • 0028533695 scopus 로고
    • The impact of development stage, route of administration, and the immune system on adenovirus-mediated gene transfer
    • KASS-EISSLER, A., FALCK-PEDERSEN, E., ELFENBEIN, D.H., ALVIRA, M., BUTTRICK, P.M., and LEINWAND, L.A. (1994). The impact of development stage, route of administration, and the immune system on adenovirus-mediated gene transfer. Gene Ther. 1, 395-402.
    • (1994) Gene Ther. , vol.1 , pp. 395-402
    • Kass-Eissler, A.1    Falck-Pedersen, E.2    Elfenbein, D.H.3    Alvira, M.4    Buttrick, P.M.5    Leinwand, L.A.6
  • 35
    • 0032498630 scopus 로고    scopus 로고
    • E4orf4, a novel adenovirus death adenovirus that induces p53-independent apoptosis by a pathway which is not inhibited by zVAD-fmk
    • LAVOIE, J.N., NGUYEN, M., MARCELLUS, R.C., BRANTON, P.E., and SHORE, G.C. (1998). E4orf4, a novel adenovirus death adenovirus that induces p53-independent apoptosis by a pathway which is not inhibited by zVAD-fmk. J. Cell Biol. 140, 637-645.
    • (1998) J. Cell Biol. , vol.140 , pp. 637-645
    • Lavoie, J.N.1    Nguyen, M.2    Marcellus, R.C.3    Branton, P.E.4    Shore, G.C.5
  • 36
    • 0030955245 scopus 로고    scopus 로고
    • E4 gene function in adenovirus, adenovirus-vector and adeno-associated virus infections
    • LEPPARD, K.N. (1997). E4 gene function in adenovirus, adenovirus-vector and adeno-associated virus infections. J. Gen.Virol. 78, 2131-2138.
    • (1997) J. Gen.virol. , vol.78 , pp. 2131-2138
    • Leppard, K.N.1
  • 40
    • 0031816872 scopus 로고    scopus 로고
    • The early region 4 orf4 protein of human adenovirus type 5 induces p53-independant cell death by apoptosis
    • MARCELLUS, R.C., LAVOIE, J.N., BOIVIN, D., SHORE, G.C., KETNER, G., and BRANTON, P.E. (1998). The early region 4 orf4 protein of human adenovirus type 5 induces p53-independant cell death by apoptosis. J. Virol. 72, 7144-7153.
    • (1998) J. Virol. , vol.72 , pp. 7144-7153
    • Marcellus, R.C.1    Lavoie, J.N.2    Boivin, D.3    Shore, G.C.4    Ketner, G.5    Branton, P.E.6
  • 41
    • 0030999469 scopus 로고    scopus 로고
    • Adenovirus-mediated gene transfer: Influence of transgene, mouse strain and type of immune response on persistence of transgene expression
    • MICHOU, A.I., SANTORO, L., CHRIST, M., JULLIARD, V., PAVIRANI, A., and MEHTALI, M. (1997). Adenovirus-mediated gene transfer: Influence of transgene, mouse strain and type of immune response on persistence of transgene expression. Gene Ther. 4, 473-482.
    • (1997) Gene Ther. , vol.4 , pp. 473-482
    • Michou, A.I.1    Santoro, L.2    Christ, M.3    Julliard, V.4    Pavirani, A.5    Mehtali, M.6
  • 42
    • 0029836780 scopus 로고    scopus 로고
    • Evaluation of the concentration and bioactivity of adenovectors for gene therapy
    • MITTEREDER, N., MARCH, K.L., and TRAPNELL, B.C. (1996). Evaluation of the concentration and bioactivity of adenovectors for gene therapy. J. Virol. 70, 7498-7509.
    • (1996) J. Virol. , vol.70 , pp. 7498-7509
    • Mittereder, N.1    March, K.L.2    Trapnell, B.C.3
  • 43
    • 0030824640 scopus 로고    scopus 로고
    • Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: Comparison of E2a wild type and E2a deleted vectors
    • MORRAL, N., O'NEAL, W., ZHOU, H., LANGSTON, C., and BEAUDET, A. (1997). Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: Comparison of E2a wild type and E2a deleted vectors. Hum. Gene Ther. 8, 1275-1286.
    • (1997) Hum. Gene Ther. , vol.8 , pp. 1275-1286
    • Morral, N.1    O'Neal, W.2    Zhou, H.3    Langston, C.4    Beaudet, A.5
  • 45
    • 0032505771 scopus 로고    scopus 로고
    • Non-specific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses
    • OTAKE, K., ENNIST, D.L., HARROD, K., and TRAPNELL, B.C. (1998). Non-specific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses. Hum. Gene Ther. 10, 2207-2222.
    • (1998) Hum. Gene Ther. , vol.10 , pp. 2207-2222
    • Otake, K.1    Ennist, D.L.2    Harrod, K.3    Trapnell, B.C.4
  • 46
    • 0030981953 scopus 로고    scopus 로고
    • Conditional repression of the E2 transcription unit in E1-E3-deleted adenovirus vectors is correlated with a strong reduction in viral DNA replication and late gene expression in vitro
    • RITTNER, K., SCHULTZ, H., PAVIRANI, A., and MEHTALI, M. (1997). Conditional repression of the E2 transcription unit in E1-E3-deleted adenovirus vectors is correlated with a strong reduction in viral DNA replication and late gene expression in vitro. J. Virol. 71, 3307-3311.
    • (1997) J. Virol. , vol.71 , pp. 3307-3311
    • Rittner, K.1    Schultz, H.2    Pavirani, A.3    Mehtali, M.4
  • 47
    • 0000557447 scopus 로고    scopus 로고
    • Adenoviridae: The viruses and their replication
    • D.M. Knipe, P.M. Howley, et al, eds. (Raven Press, Philadelphia)
    • SHENK, T. (1996). Adenoviridae: the viruses and their replication. In Virology. D.M. Knipe, P.M. Howley, et al, eds. (Raven Press, Philadelphia) pp. 2111-2148.
    • (1996) Virology , pp. 2111-2148
    • Shenk, T.1
  • 48
    • 0031949940 scopus 로고    scopus 로고
    • Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells
    • SHTRICHMAN, R., and KLEINBERGER, T. (1998). Adenovirus type 5 E4 open reading frame 4 protein induces apoptosis in transformed cells. J. Virol. 72, 2975-2982.
    • (1998) J. Virol. , vol.72 , pp. 2975-2982
    • Shtrichman, R.1    Kleinberger, T.2
  • 49
    • 0030770344 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte responses to proteins encoded by heterologous transgenes transferred in vivo by adenoviral vectors
    • SONG, W., KONG, H.-L., TRAKTMAN, P., and CRYSTAL, R.G. (1997). Cytotoxic T lymphocyte responses to proteins encoded by heterologous transgenes transferred in vivo by adenoviral vectors. Hum. Gene Ther. 8, 1207-1217.
    • (1997) Hum. Gene Ther. , vol.8 , pp. 1207-1217
    • Song, W.1    Kong, H.-L.2    Traktman, P.3    Crystal, R.G.4
  • 50
    • 0027768571 scopus 로고
    • Adenoviral vectors for gene transfer
    • TRAPNELL, B.C. (1993). Adenoviral vectors for gene transfer. Adv. Drug Deliv. Rev. 12, 185-199.
    • (1993) Adv. Drug Deliv. Rev. , vol.12 , pp. 185-199
    • Trapnell, B.C.1
  • 51
    • 0029936764 scopus 로고    scopus 로고
    • Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors
    • TRIPATHY, S.K., BLACK, H.B., GOLDWASSER, E., and LEIDEN, J.M. (1996). Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors. Nature Med. 2, 545-550.
    • (1996) Nature Med. , vol.2 , pp. 545-550
    • Tripathy, S.K.1    Black, H.B.2    Goldwasser, E.3    Leiden, J.M.4
  • 52
    • 0031008929 scopus 로고    scopus 로고
    • Persistent transgene expression in mouse liver following in vivo gene transfer with a ΔE1/ΔE4 adenovirus vector
    • WANG, Q., GREENBURG, G., BUNCH, D., FARSON, D., and FINER, M.H. (1997). Persistent transgene expression in mouse liver following in vivo gene transfer with a ΔE1/ΔE4 adenovirus vector. Gene Ther. 4, 393-400.
    • (1997) Gene Ther. , vol.4 , pp. 393-400
    • Wang, Q.1    Greenburg, G.2    Bunch, D.3    Farson, D.4    Finer, M.H.5
  • 53
    • 0028229147 scopus 로고
    • Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis
    • YANG, Y., NUNES, F.A., BERENCSI, K., GÖNCZÖL, E., ENGELHARDT, J.F., and WILSON, J.M.. (1994). Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis. Nature Genet. 7, 362-369.
    • (1994) Nature Genet. , vol.7 , pp. 362-369
    • Yang, Y.1    Nunes, F.A.2    Berencsi, K.3    Gönczöl, E.4    Engelhardt, J.F.5    Wilson, J.M.6
  • 54
    • 0028937785 scopus 로고
    • Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
    • YANG, Y., LIN, Q., ERTL, H.C.J., and WILSON, J.M. (1995). Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. J. Virol. 69, 2004-2015.
    • (1995) J. Virol. , vol.69 , pp. 2004-2015
    • Yang, Y.1    Lin, Q.2    Ertl, H.C.J.3    Wilson, J.M.4
  • 55
    • 9244220682 scopus 로고    scopus 로고
    • Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo
    • YANG, Y., JOOSS, K.U., SU, Q., ERTL, H.C.J., and WILSON, J.M. (1996a). Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo. Gene Ther. 3, 137-144.
    • (1996) Gene Ther. , vol.3 , pp. 137-144
    • Yang, Y.1    Jooss, K.U.2    Su, Q.3    Ertl, H.C.J.4    Wilson, J.M.5
  • 56
    • 0029836503 scopus 로고    scopus 로고
    • Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs
    • YANG, Y., SU, Q., and WILSON, J.M. (1996b). Role of viral antigens in destructive cellular immune responses to adenovirus vector-transduced cells in mouse lungs. J. Virol. 70, 7209-7212.
    • (1996) J. Virol. , vol.70 , pp. 7209-7212
    • Yang, Y.1    Su, Q.2    Wilson, J.M.3
  • 57
    • 0029803090 scopus 로고    scopus 로고
    • Adenovirus-mediated transfer of human factor ix gene in immunodeficient and normal mice: Evidence for prolonged stability and activity of the transgene in liver
    • YAO, S.N., FARJO, A., ROESSLER, B.J., DAVIDSON, B.L., and KURACHI, K. (1996). Adenovirus-mediated transfer of human factor IX gene in immunodeficient and normal mice: Evidence for prolonged stability and activity of the transgene in liver. Viral Immunol. 9, 141-153.
    • (1996) Viral Immunol. , vol.9 , pp. 141-153
    • Yao, S.N.1    Farjo, A.2    Roessler, B.J.3    Davidson, B.L.4    Kurachi, K.5
  • 58
    • 0029655456 scopus 로고    scopus 로고
    • Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit
    • YEH, P., DEDIEU, J.F., ORSINI, C., VIGNE, E., DENEFLE, P., and PERRICAUDET, P. (1996). Efficient dual transcomplementation of adenovirus E1 and E4 regions from a 293-derived cell line expressing a minimal E4 functional unit. J. Virol. 70, 559-565.
    • (1996) J. Virol. , vol.70 , pp. 559-565
    • Yeh, P.1    Dedieu, J.F.2    Orsini, C.3    Vigne, E.4    Denefle, P.5    Perricaudet, P.6


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