Replication-defective vector based on a chimpanzee adenovirus

Journal of Virology

Volumn 75, Issue 23, 2001, Pages 11603-11613

  Farina, S F ^a   Gao, G P ^a   Xiang, Z Q ^a   Rux, J J ^a   Burnett, R M ^a   Alvira, M R ^a   Marsh, J ^a   Ertl, H C J ^a   Wilson, J M ^a  

^a WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NEUTRALIZING ANTIBODY; VIRUS RECEPTOR; VIRUS VECTOR;

ADENOVIRUS; ANIMAL CELL; ARTICLE; CHIMPANZEE; CONTROLLED STUDY; GENE CASSETTE; GENE SEQUENCE; HUMAN; HUMAN ADENOVIRUS; HUMAN CELL; MESENTERY LYMPH NODE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RHESUS MONKEY; SEQUENCE ANALYSIS; SEROTYPE; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; VIRUS GENOME; VIRUS ISOLATION; VIRUS REPLICATION;

ADENOVIRIDAE; AMINO ACID SEQUENCE; ANIMALS; CAPSID; CAPSID PROTEINS; CLONING, MOLECULAR; GENETIC VECTORS; GENOME, VIRAL; HUMANS; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEUTRALIZATION TESTS; OPEN READING FRAMES; PAN TROGLODYTES; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0035164962     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.75.23.11603-11613.2001     Document Type: Article

References (39)

1. The refined crystal structure of hexon, the major coat protein of adenovirus type 2, at 2.9 Å resolution
2. Subgroup B adenovirus type 35 early region 3 mRNAs differ from those of the subgroup C adenoviruses
3. Characterization of four new adenovirus serotypes isolated from chimpanzee tissue explants
4. Generation of adenovirus by transfection of plasmids
5. CHARMM: A program for macromolecular energy, minimization, and dynamics calculations
6. Immune responses to adenovirus and adeno-associated virus in humans
7. Modulation of the inflammatory properties and hepatotoxicity of recombinant adenovirus vectors by the viral E4 gene products
8. Analysis of 15 adenovirus hexon proteins reveals the location and structure of seven hypervariable regions containing serotype-specific residues
9. High throughput method for creating and screening recombinant adenoviruses
10. Long-term gene delivery into the livers of immunocompetent mice with E1/E4-defectlve adenoviruses
11. An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptor-independent cell entry mechanism
12. Transduction with recombinant adeno-associated virus for gene therapy is limited by leading-strand synthesis
13. Humoral immune response to the capsid components of recombinant adenoviruses: Routes of immunization modulate virus-induced lg subclass shifts
14. Adenovirus type 5 and 7 capsid chimera: Fiber replacement alters receptor tropism without affecting primary immune neutralization epitopes
15. Construction and characterization of hexon-chimeric adenoviruses: Specification of adenovirus serotype
16. Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy
17. Characteristics of a human cell line transformed by DNA from human adenovirus type 5
18. SWISS-MODEL and the Swiss-Pdb-Viewer: An environment for comparative protein modeling
19. Improved adenovirus vectors for infection of cardiovascular tissues
20. Long-term humoral and cellular immunity induced by a single immunization with replication-defective adenovirus recombinant vector
21. Restriction mapping and molecular cloning of adenovirus type 4 (subgroup E) DNA
22. In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses
23. The degree of genetic variability among adenovirus type 4 strains isolated from man and chimpanzee
24. Immune responses to reporter proteins and high viral dose limit duration of expression with adenoviral vectors: Comparison of E2a wild type and E2a deleted vectors
25. Pseudopackaging of adenovirus type 5 genomes into capsids containing the hexon proteins of adenovirus serotypes B, D, or E
26. Circumvention of immunity to the adenovirus major coat protein hexon
27. Type-specific epitope locations revealed by X-ray crystallographic study of adenovirus type 5 hexon
28. + cells by a retargeted adenovirus vector
29. Immune responses to transgene-encoded proteins limit the stability of gene expression after injection of replication-defective adenovirus vectors
30. Persistent transgene expression in mouse liver following in vivo gene transfer with a ΔE1/ΔE4 adenovirus vector
31. Increased in vitro and in vivo gene transfer by adenovirus vectors containing chimeric fiber proteins
32. Chimpanzee adenoviruses are related to four subgenera of human adenoviruses
33. Immunological relationship among adenoviruses of humans, simians, and nonprimates as determined by the neutralization test
34. MHC class I-restricted cytotoxic T lymphocytes to viral antigens destroy hepatocytes in mice infected with E1-deleted recombinant adenoviruses
35. Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses
36. Recombinant IL-12 prevents formation of blocking IgA antibodies to recombinant adenovirus and allows repeated gene therapy to mouse lung
37. Adenovirus-mediated transfer of human factor IX gene in immunodeficient and normal mice: Evidence for prolonged stability and activity of the transgene in liver
38. Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice