Selective allosteric enhancement of agonist binding and function at human A3 adenosine receptors by a series of imidazoquinoline derivatives

Molecular Pharmacology

Volumn 62, Issue 1, 2002, Pages 81-89

  Gao, Zhan Guo ^a   Kim, Seong Gon ^a   Soltysiak, Kelly A ^a   Melman, Neli ^a   Ijzerman, Adriaan P ^a   Jacobson, Kenneth A ^a,b  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

1H IMIDAZO [4,5 C]QUINOLINE; 2 [4 (2 CARBOXYETHYL)PHENYLETHYLAMINO] 5' N ETHYLCARBOXAMIDOADENOSINE; 2 CYCLOPENTYL 1H IMIDAZO[4,5 C]QUINOLINE DERIVATIVE; 2 CYCLOPENTYL 4 PHENYLAMINO 1H IMIDAZO[4,5 C]QUINOLINE; 4 ANILINO 2 CYCLOPENTYLIMIDAZO[4,5 C]QUINOLINE; 8 ETHYL 4 METHYL 2 PHENYL 4,5,7,8 TETRAHYDRO 1H IMIDAZO[2,1 I]PURIN 5 ONE; ADENOSINE A3 RECEPTOR; CYCLIC AMP; FORSKOLIN; IMIDAZOQUINOLINE DERIVATIVE; N6 (4 AMINO 3 IODOBENZYL) 5' N METHYLCARBOXAMIDOADENOSINE; PHENYLISOPROPYLADENOSINE; PSB 11; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BRAIN ISCHEMIA; COMPETITIVE BEHAVIOR; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISSOCIATION; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADENOSINE; ALLOSTERIC REGULATION; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; IMIDAZOLES; IODINE RADIOISOTOPES; PHENETHYLAMINES; PURINES; QUINOLINES; RADIOLIGAND ASSAY; RATS; RECEPTOR, ADENOSINE A2A; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; TRIAZINES; TRIAZOLES; TRITIUM; XANTHINES;

EID: 0036088519     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.1.81     Document Type: Article

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