Ring-constrained (N)-methanocarba nucleosides as adenosine receptor agonists: Independent 5′-uronamide and 2′-deoxy modifications

Bioorganic and Medicinal Chemistry Letters

Volumn 11, Issue 10, 2001, Pages 1333-1337

  Lee, Kyeong ^a   Ravi, Gnana ^a   Ji, Xiao Duo ^a   Marquez, Victor E ^b   Jacobson, Kenneth A ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE DERIVATIVE; ADENOSINE RECEPTOR STIMULATING AGENT; METHANOCARBAADENOSINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DRUG CONFORMATION; DRUG EFFICACY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; NONHUMAN; RADIOASSAY; RAT; REACTION ANALYSIS;

ADENINE; ADENOSINE; ANIMALS; BINDING, COMPETITIVE; BRAIN; CELL LINE; CELL MEMBRANE; CHO CELLS; CRICETINAE; CYCLOPENTANES; HUMANS; NUCLEOSIDES; PROTEIN BINDING; RATS; RECEPTORS, PURINERGIC P1; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

ANIMALIA;

EID: 0035927233     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(01)00213-X     Document Type: Article

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14. -).
15. max 260.0 nm. HRMS (FAB) calcd 319.1519, found 319.1510.
16. max 271.0 nm. HRMS (FAB) calcd 353.1129, found 353.1139.
17. 3OD) δ 8.46 (s, 1H, C-8), 7.77 (s, 1H), 7.59 (d, 1H, J=7.81 Hz), 7.39 (d, 1H, J=7.81 Hz), 7.09 (t, 1H, J=7.81 Hz), 4.96 (d, 1H, J=5.86 Hz), 4.7 (s, 2H), 4.27 (d, 1H, J=11.72 Hz), 3.36 (d, 1H, J=11.72 Hz), 2.1-1.96 (m, 1H), 1.9-1.7 (m, 1H), 1.7-1.6 (m, 1H), 1.04-1.01 (m, 1H), 0.82-0.74 (m, 1H). HRMS (FAB) calcd 512.0350, found 512.0358.
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