Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men

American Journal of Physiology - Endocrinology and Metabolism

Volumn 282, Issue 1, 2002, Pages

  Tanner, Charles J ^a,b   Koves, Timothy R ^c   Cortright, Ronald L ^a,b,c   Pories, Walter J ^c   Kim, Young Bum ^d   Kahn, Barbara B ^d   Dohm, G Lynis ^a,c   Houmard, Joseph A ^a,b  

^a Diabetes Obesity Center   (United States)

^b Departments of Exercise and Sport Science   (United States)

^c EAST CAROLINA UNIVERSITY   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Aging; Glucose transport; Insulin resistance; Physical activity; Skeletal muscle

Indexed keywords

GLUCOSE; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ADULT; AGE; AGED; AGING; ARTICLE; ENZYME ACTIVITY; EXERCISE; GLUCOSE CLAMP TECHNIQUE; HORMONE ACTION; HUMAN; HUMAN EXPERIMENT; HYPERINSULINEMIA; INSULIN SENSITIVITY; MALE; NORMAL HUMAN; OXYGEN CONSUMPTION; PRIORITY JOURNAL; SKELETAL MUSCLE; TRAINING;

EID: 0036079360     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.2002.282.1.e147     Document Type: Article

References (41)

1. The coupling of glucose metabolism and perfusion in human skeletal muscle: The potential role of endothelium-derived nitric oxide
2. Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
3. Effects of exercise training on muscle GLUT-4 protein content and translocation in obese Zucker rats
4. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
5. Effect of aging on insulin receptor, insulin receptor substrate-1 and phosphatidylinositol 3-kinase in liver and muscle of rats
6. Exercise-induced changes in expression and activity of proteins involved in insulin signal transduction in skeletal muscle: Differential effects on insulin-receptor substrates 1 and 2
7. Seven consecutive days of exercise lowers plasma insulin responses to an oral glucose challenge in sedentary elderly
8. Effect of aging on response to exercise training in humans: Skeletal muscle GLUT-4 and insulin sensitivity
9. Insulin resistance differentially affects the PI 3-kinase and MAP kinase-mediated signaling in human muscle
10. Signaling mechanisms that regulate glucose transport
11. Glucose intolerance and aging
12. Glucose clamp technique: A method for quantifying secretion and resistance
13. Hyperinsulinemia, risk factors, and coronary heart disease. The Zutphen Elderly Study
14. Effects of contractile activity on tyrosine phosphoproteins and PI 3-kinase activity in rat skeletal muscle
15. Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese patients
16. Exercise, glucose transport, and insulin sensitivity
17. Insulin activation of phosphatidylinositol 3-kinase in human skeletal muscle in vivo
18. Elevated skeletal muscle glucose transporter levels in exercise-trained middle-aged men
19. Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in human skeletal muscle
20. Mechanisms of age-related glucose intolerance
21. Generalized equations for predicting body density of men
22. Insulin action, diabetogenes, and the cause of type II diabetes
23. Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
24. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation phosphoinositide 3-kinase, in muscle in type 2 diabetes
25. Divergent regulation of Akt 1 and Akt2 isoforms in insulin target tissues of obese Zucker rats
26. Regular exercise enhances insulin activation of IRS-1 associated PI 3-kinase in human skeletal muscle
27. Insulin stimulated the kinase activity of RAC-PK, a pleckstrin homology by domain containing ser/thr kinase
28. Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects
29. Improvement of insulin action in diabetic transgenic mice selectively overexpressing GLUT 4 in skeletal muscle
30. Specific activity of phosphatidylinositol 3-kinase is increased by insulin stimulation
31. Pathophysiology of insulin resistance in human disease
32. Overexpression of GLUT4 protein in muscle increases basal and insulin-stimulated whole body glucose disposal in conscious mice
33. Improvement in glucose tolerance after 1 wk of exercise in patients with mild NIDDM
34. Diverse signaling pathways in the cellular actions of insulin
35. Differential regulation of phosphoinositide 3-kinase adapter subunit variants by insulin in human muscle
36. Phosphoinositide 3-kinase: The key switch in insulin signaling
37. Increased insulin sensitivity and hypoglycemia in mice lacking the p85α subunit of phosphoinositide 3-kinase
38. Enhanced insulin action due to targeted GLUT 4 overexpression exclusively in muscle
39. Amelioration of insulin resistance but not hyperinsulinemia in obese mice overexpressing GLUT 4 selectively in skeletal muscle
40. Insulin signaling and insulin sensitivity after exercise in human skeletal muscle
41. Insulin signaling in human skeletal muscle: Time course and effect of exercise