Stromal cell oxidation: A mechanism by which tumors obtain vitamin C

Cancer Research

Volumn 59, Issue 18, 1999, Pages 4555-4558

  Agus, David B ^a   Vera, Juan C ^a   Golde, David W ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; DEHYDROASCORBIC ACID; GLUCOSE; GLUCOSE TRANSPORTER; LEVO GLUCOSE; SUPEROXIDE DISMUTASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; COMPETITIVE INHIBITION; ISOTOPE LABELING; MALE; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; STROMA CELL; VITAMIN METABOLISM; XENOGRAFT;

ANIMALS; ASCORBIC ACID; BIOLOGICAL TRANSPORT; BREAST NEOPLASMS; FEMALE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 1; HL-60 CELLS; HUMANS; LEUKEMIA, LYMPHOCYTIC, ACUTE; MALE; MICE; MICE, NUDE; MODELS, BIOLOGICAL; MONOSACCHARIDE TRANSPORT PROTEINS; PROSTATIC NEOPLASMS; STROMAL CELLS; TRANSPLANTATION, HETEROLOGOUS;

EID: 0033567885     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (22)

1. Chatterjee, I. B., Majumder, A. K., Nandi, B. K., and Subramanian, N. Synthesis and major functions of vitamin C in animals. Ann. N. Y. Acad. Sci., 258: 24-47, 1975.
2. Hodges, R. E., Hood, J., Canham, J. E., Sauberlich, H. E., and Baker, E. M. Clinical manifestations of ascorbic acid deficiency in man. Am. J. Clin. Nutr., 24: 432-443, 1971.
3. Pauling, L. Ascorbic acid and the common cold. Am. J. Clin. Nutr., 24: 1294-1299, 1971.
4. Leibovitz, B., and Siegel, B. V. Ascorbic acid, neutrophil function, and the immune response. Int. J. Vitam. Nutr. Res., 48: 159-164, 1978.
5. Baader, S. L., Bruchelt, G., Trautner, M. C., Boschert, H., and Niethammer, D. Uptake and cytotoxicity of ascorbic acid and dehydroascorbic acid in neuroblastoma (SK-N-SH) and neuroectodermal (SK-N-LO) cells). Anticancer Res., 14: 221-227, 1994.
6. Spielholz, C., Golde, D. W., Houghton, A. N., Nualart, F., and Vera, J. C. Increased facilitated transport of dehydroascorbic acid without changes in sodium-dependent ascorbate transport in human melanoma cells. Cancer Res., 57: 2529-2537, 1997.
7. Langemann, H., Torhorst, J., Kabiersch, A., Krenger, W., and Honegger, C. G. Quantitative determination of water- and lipid-soluble antioxidants in neoplastic and non-neoplastic human breast tissue. Int. J. Cancer, 43: 1169-1173, 1989.
8. Vera, J. C., Rivas, C. I., Fischbarg, J., and Golde, D. W. Mammalian facilitative hexose transporters mediate the transport of dehydroascorbic acid. Nature (Lond.), 364: 79-82, 1993.
9. Vera, J. C., Rivas, C. I., Zhang, R. H., Farber, C. M., and Golde, D. W. Human HL-60 myeloid leukemia cells transport dehydroascorbic acid via the glucose transporters and accumulate reduced ascorbic acid. Blood, 84: 1628-1634, 1994.
10. Vera, J. C., Rivas, C. I., Velasquez, F. V., Zhang, R. H., Concha, I. I., and Golde, D. W. Resolution of the facilitated transport of dehydroascorbic acid from its intracellular accumulation as ascorbic acid. J. Biol. Chem., 270: 23706-23712, 1995.
11. Agus, D. B., Gambhir, S. S., Pardridge, W. M., Spielholz, C., Baselga, J., Vera, J. C., and Golde, D. W. Positron emission tomography (PET) of a human prostate cancer xenograft: the association of changes in deoxyglucose accumulation and response to hormonal therapy. J. Clin. Invest., 100: 2842-2848, 1997.
12. +-dependent L-ascorbic acid transporters. Nature (Lond.), 399: 70-75, 1999.
13. Triguero, D., Buciak, J., and Pardridge, W. M. Capillary depletion method for quantification of blood brain barrier transport of circulating peptides and plasma proteins. J. Neurochem., 54: 1882-1888, 1990.
14. Matsubara, T., and Ziff, M. Increased superoxide anion release from human endothelial cells in response to cytokines. J. Immunol., 137: 3295-3298, 1986.
15. Bellavite, P. The superoxide-forming enzymatic system of phagocytes. Free Radical Biol. Med., 4: 225-261, 1988.
16. Thomas, E. L., Learn, D. B., Jefferson, M. M., and Weatherred, W. Superoxide-dependent oxidation of extracellular reducing agents by isolated neutrophils. J. Biol. Chem., 263: 2178-2186, 1988.
17. Meier, B., Cross, A. R., Hancock, J. T., Kaup, F. J., and Jones, O. T. Identification of a superoxide-generating NADPH oxidase system in human fibroblasts. Biochem. J., 275: 241-245, 1991.
18. Vera, J. C., Rivas, C. I., Zhang, R. H., and Golde, D. W. Colony-stimulating factors signal for increased transport of vitamin C in human host defense cells. Blood, 91: 2536-2546, 1998.
19. Washko, P. W., Wang, Y., and Levine, M. Ascorbic acid recycling in human neutrophils. J. Biol. Chem., 268: 15531-15535, 1993.
20. Park, C. H., Bergsagel, D. E., and McCulloch, E. A. Ascorbic acid: a culture requirement for colony formation by mouse plasmacytoma cells. Science (Washington DC), 174: 720-722, 1971.
21. Levine, M., Conry-Cantilena, C., Wang, Y., Welch, R. W., Washko, P. W., Dhariwal, K. R., Park, J. B., Lazarev, A., Graumlich, J. F., King, J., and Cantilens, L. R. Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc. Natl. Acad. Sci. USA, 93: 3704-3709, 1996.
22. Moertel, C. G., Fleming, T. R., Creagan, E. T., Rubin, J., O'Connell, M. J., and Ames, M. M. High-dose vitamin C versus placebo in the treatment of patients with advanced cancer who have had no prior chemotherapy. N. Engl. J. Med., 312: 137-141, 1985.