Lactate-induced translocation of GLUT1 and GLUT4 is not mediated by the phosphatidyl-inositol-3-kinase pathway in the rat heart

Basic Research in Cardiology

Volumn 97, Issue 2, 2002, Pages 168-176

  Medina, Rodolfo A ^a   Southworth, Richard ^a   Fuller, William ^b   Garlick, Pamela B ^a  

^a GUY S HOSPITAL   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

Author keywords

GLUT1; GLUT4; Lactate; Langendorff perfusion; Wortmannin

Indexed keywords

DEOXYGLUCOSE; FLUORODEOXYGLUCOSE F 18; GLUCOSE; GLUCOSE 6 PHOSPHATE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 4; LACTIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; WORTMANNIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DIET RESTRICTION; DRUG EFFECT; DRUG INHIBITION; FEEDING; GENE TRANSLOCATION; GLUCOSE TRANSPORT SYSTEM; HEART; HEART MUSCLE FIBER MEMBRANE; HEART MUSCLE ISCHEMIA; HEART PERFUSION; ISOLATED HEART; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUTRITIONAL STATUS; PHOSPHORYLATION; RAT; WESTERN BLOTTING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANDROSTADIENES; ANIMAL NUTRITION PHYSIOLOGY; ANIMALS; BIOLOGICAL TRANSPORT; ENZYME INHIBITORS; FLUORODEOXYGLUCOSE F18; GLUCOSE TRANSPORTER TYPE 1; GLUCOSE TRANSPORTER TYPE 4; GLUCOSE-6-PHOSPHATE; HEART; LACTIC ACID; MALE; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; MYOCARDIAL CONTRACTION; MYOCARDIUM; PERFUSION; PHOSPHORYLATION; RADIOPHARMACEUTICALS; RATS; RATS, WISTAR; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0036120932     PISSN: 03008428     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003950200008     Document Type: Article

References (32)

1. Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-triphosphate in neutrophil response
2. Myocardial protection by insulin is dependent on phosphatidylinositol 3-kinase but not protein kinase C or KATP channels in the isolated rabbit heart
3. A molecular basis for the mechanism of insulin action
4. Persistent myocardial ischaemia increases GLUT1 glucose transporter expression in both ischaemic and non-ischaemic heart regions
5. 18F]2-deoxy-2-fluoroglucose in reperfused rat heart muscle
6. Insulin does not change the intracellular distribution of hexokinase in rat heart
7. Contribution of α-adrenergic and β-adrenergic stimulation to ischaemia induced glucose transport (GLUT) 4 and GLUT1 translocation in the isolated perfused rat heart
8. Glucose transport and glucose transporter GLUT4 are regulated by product(s) of intermediary metabolism in cardiomyocytes
9. Differential centrifugation separates cardiac sarcolemmal and endosomal membranes from Langendorff-perfused rat hearts
10. PET and NMR dual acquisition (PANDA): Applications to isolated perfused rat hearts
11. Differential uptake of FDG and DG during post-ischaemic reperfusion in the isolated, perfused rat heart
12. Hexokinase binding in ischemic and reperfused piglet brain
13. Myocardial lactate release during prolonged exercise under hypoxaemia
14. Glucose transporters and in vivo glucose uptake in skeletal and cardiac muscle: Fasting, insulin stimulation and immunoisolation studies of GLUT1 and GLUT4
15. Adenosine and adenosine triphosphate modulate the substrate binding affinity of glucose transporter GLUT1 in vitro
16. Cleavage of the structural proteins during the assembly of the head of bacteriophage T4
17. Glucose transport and phosphorylation in single cardiac myocytes: Rate-limiting steps in glucose metabolism
18. Myocardial metabolism during hypoxia: Maintained lactate oxidation during increased glycolysis
19. Post-ischaemic stimulation of 2-deoxyglucose uptake in rat myocardium: Role of translocation of GLUT4
20. Interactions of sodium pentobarbital with D-glucose and L-sorbose transport in human red cells
21. 18F]fluoro-2-deoxy-D-glucose
22. Transport of lactate and other monocarboxylates across mammalian plasma membranes
23. Compartmentation of hexokinase in rat heart
24. Feeding and fasting determine postischemic glucose utilisation in isolated working rat hearts
25. Competition between lactate and fatty acids as sources of ATP in the isolated working rat heart
26. Translocation of the glucose transporter GLUT4 in cardiac myocytes of the rat
27. Myocardial lactate metabolism during exercise
28. Ischemia induces translocation of the insulin-responsive glucose transporter GLUT4 to the plasma membrane of cardiac myocytes
29. Evidence for functional hexokinase compartmentation in rat skeletal muscle mitochondria
30. Effect of food deprivation on rat plasma estrone fatty acid esters
31. Low-flow ischaemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo
32. Regulation of glucose transport, and glucose transporters expression and trafficking in the heart: Studies in cardiac myocytes