Sex hormones induce insulin resistance in 3T3-L1 adipocytes by reducing cellular content of IRS proteins

Diabetologia

Volumn 43, Issue 11, 2000, Pages 1374-1380

  Collison, M ^a   Campbell, I W ^a   Salt, I P ^a   Dominiczak, A F ^b   Connell, J M C ^b   Lyall, H ^c   Gould, G W ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b WESTERN INFIRMARY   (United Kingdom)

^c GLASGOW ROYAL INFIRMARY   (United Kingdom)

Author keywords

Estradiol; Estriol; Estrone; Insulin resistance; IRS proteins

Indexed keywords

ESTRADIOL; ESTRIOL; ESTRONE; GLUCOSE TRANSPORTER; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHATIDYLINOSITOL 3 KINASE; SEX HORMONE;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GLUCOSE TRANSPORT; HORMONE ACTION; INSULIN RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN LOCALIZATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3-O-METHYLGLUCOSE; 3T3 CELLS; ADIPOCYTES; ANIMALS; BIOLOGICAL TRANSPORT; DEOXYGLUCOSE; ESTRADIOL; ESTRIOL; ESTRONE; GLUCOSE; GLUCOSE TRANSPORTER TYPE 4; GONADAL STEROID HORMONES; INSULIN; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MONOSACCHARIDE TRANSPORT PROTEINS; MUSCLE PROTEINS; PHOSPHOPROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT;

EID: 0033736111     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250051541     Document Type: Article

References (32)

1. Resistance to insulin-mediated glucose disposal as a predicator of cardiovascular disease
2. Hyperglycaemia and cardiovascular disease in Type II diabetes
3. Cardiovascular disease and hypertension in diabetes mellitus
4. Effect of exogenous estrogen on carbohydrate metabolism in postmenopausal women
5. Ischemic heart disease risk in postmenopausal women
6. Profound insulin resistance independent of obesity in the polycystic ovary syndrome
7. Insulin resistance in polycytic ovary syndrome
8. Insulin resistance, secretion, and elimination in postmenopausal women receiving oral or transdermal hormone replacement therapy
9. The effects of the menopause on insulin sensitivity, secretion and elimination in non-obese, healthy women
10. The effects of hormone replacement therapy on insulin sensitivity in surgically postmenopausal cynomolgus monkeys (Macaca fascicularis)
11. Insulin resistance and diminuished glucose tolerance in powerlifters ingesting anabolic steriods
12. The effect of anabolic steriods on blood sugar and plasma insulin levels in men
13. Induction of insulin resistance by androgens and estrogens
14. The influemce of androgens on insulin resistance
15. Metformin therapy in polycystic ovary syndrome reduces hyperinsulinaemia, insulin resistance, hyperandrogenemia and systolic blood pressure, while facilitating normal menses and pregnancy
16. Causes of insulin resistance
17. Dynamics of insulin signaling in 3T3-L1 adipocytes
18. The insulin signalling system
19. Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance
20. Intracellular localisation of phosphatidylinositide 3-kinase and insulin receptor substrate-1 in adipocytes: Potential involvement of a membrane skeleton
21. Immunological analysis of glucose transporters expressed in different regions of the rat brain and central nervous system
22. Analysis of the co-localization of the insulin-responsive glucose transporter (GLUT4) and the trans Golgi network marker TGN38 within 3T3-L1 adipocytes
23. Differential regulation of secretory compartments containing the insulin-responsive glucose transporter, GLUT4, in 3T3-L1 adipocytes
24. Evidence for a role for ADP-ribosylation factor 6 in insulin-stimulated glucose transporter-4 (GLUT4) trafficking in 3T3-L1 adipocytes
25. Evidence for the involvement of vicinal sulphydryl groups in insulin-activated hexose transport in 3T3-L1 adipocytes
26. Insulin-induced translocation of glucose transporters to the plasma membrane precedes full stimulation of hexose transport
27. V- and t-SNARE protein expression in models of insulin resistance: Normalisation of glycemia by rosiglitazone treatment corrects over-expression of cellubrevn, VAMP2 and syntaxin 4 in skeletal muscle of Zucker Diabetic Fatty (ZDF) rats
28. Cellular insulin action and insulin resistance
29. Diverse signalling pathways in the cellular actions of insulin
30. Phosphoinositide 3-kinase: The key switch in insulin signal transduction
31. A role for protein kinase B/Akt2 in insulin-stimulated GLUT4 translocation in adipocytes