AMPA receptor-mediated toxicity in oligodendrocyte progenitors involves free radical generation and activation of JNK, calpain and caspase 3

Journal of Neurochemistry

Volumn 82, Issue 2, 2002, Pages 398-409

  Liu, Hsueh Ning ^a   Giasson, Benoit I ^a   Mushynski, Walter E ^a   Almazan, Guillermina ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

AMPA receptors; Ca2+ influx; Caspases; Cell death; Glutamate; Oligodendrocyte progenitors

Indexed keywords

1 (4 AMINOPHENYL) 4 METHYL 7,8 METHYLENEDIOXY 5H 2,3 BENZODIAZEPINE; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ACETYLCYSTEINE; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; BUTHIONINE SULFOXIMINE; CALCIUM; CALPAIN; CALPASTATIN; CASPASE 3; CASPASE 3 INHIBITOR; CYCLOTHIAZIDE; DIZOCILPINE; DNA FRAGMENT; FODRIN; FREE RADICAL; GLUTATHIONE; PD 150606; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CALCIUM TRANSPORT; CHROMATIN CONDENSATION; CONTROLLED STUDY; DESENSITIZATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME SUBSTRATE; MOLECULAR MECHANICS; NERVE CELL CULTURE; NERVE CELL NECROSIS; NEUROPROTECTION; NEUROTOXICITY; NEWBORN; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; REGULATORY MECHANISM; STEM CELL;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; APOPTOSIS; CALCIUM; CALPAIN; CASPASE 3; CASPASES; CELLS, CULTURED; CYTOPROTECTION; ENZYME ACTIVATION; ENZYME INHIBITORS; EXCITATORY AMINO ACID AGONISTS; FREE RADICALS; GLUTATHIONE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEUROTOXINS; OLIGODENDROGLIA; RATS; RECEPTORS, AMPA; SIGNAL TRANSDUCTION; SPECTRIN; STEM CELLS;

ANIMALIA;

EID: 0036069280     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2002.00981.x     Document Type: Article

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