NBQX attenuates excitotoxic injury in developing white matter

Journal of Neuroscience

Volumn 20, Issue 24, 2000, Pages 9235-9241

  Follett, Pamela L ^a   Rosenberg, Paul A ^a   Volpe, Joseph J ^a   Jensen, Frances E ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

AMPA; Excitotoxicity; Glutamate receptors; NBQX; Oligodendrocytes; White matter

Indexed keywords

6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; GLUTAMATE RECEPTOR; GLUTAMIC ACID; MYELIN BASIC PROTEIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; BRAIN HYPOXIA; BRAIN ISCHEMIA; CAROTID ARTERY LIGATION; CEREBRAL PALSY; CYTOPATHOGENIC EFFECT; GENE EXPRESSION; LEUKOMALACIA; MALE; NONHUMAN; OLIGODENDROGLIA; PREMATURITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; WHITE MATTER;

EID: 0034671193     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-24-09235.2000     Document Type: Article

References (54)

1. Evaluation of brain damage in a rat model of neonatal hypoxic-ischemia
2. CNS myelination in vitro: Time course and pattern of rat oligodendrocyte development
3. Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced apoptosis caused by glutathione
4. Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis
5. 2+ permeation of AMPA receptors in cerebellar neurons expressing Glu receptor 2
6. Early and late neuropathological changes in perinatal white matter damage
7. AMPA receptor activation is rapidly toxic to cortical astrocytes when desensitization is blocked
8. Rapid ischemic cell death in immature oligodendrocytes: A fatal glutamate release feedback loop
9. Excitatory amino acid receptors in glial progenitor cells: Molecular and functional properties
10. Two proliferative stages of the oligodendrocyte lineage (A2B5+O4- and O4+GalC-) under different mitogenic control
11. Neonatal endotoxin encephalopathy
12. Hypoxic-ischemic damage in the neonatal brain: Excitatory amino acids
13. Hypoxia-ischemia in the neonatal rat brain: Histopathology after post-treatment with NMDA and non-NMDA receptor antagonists
14. Proliferation and differentiation potential of rat forebrain oligodendroglial progenitors both in vitro and in vivo
15. Oligodendroglial progenitors labeled with the O4 antibody persist in the adult rat cerebral cortex in vivo
16. Immunohistochemical study of myelination and oligodendrocyte in infants with periventricular leukomalacia
17. Physiologic and histologic changes in near-term fetal lambs
18. Periventricular white matter injury in the premature infant is followed by reduced cerebral cortical gray matter volume at term
19. The putative essential nutrient pyrroloquinoline quinone is neuroprotective in a rodent model of hypoxic/ischemic brain injury
20. Human oligodendroglial development: Relationship to periventricular leukomalacia
21. Spatial and temporal patterns of oligodendrocyte differentiation in rat cerebrum and cerebellum
22. Mechanisms of ionotropic glutamate receptor-mediated excitotoxicity in isolated spinal cord white matter
23. Novel injury mechanism in anoxia and trauma of spinal cord white matter: Glutamate release via reverse Na+-dependent glutamate transport
24. Oligodendrocytes and microglia are selectively vulnerable to combined hypoxia and hypoglycemia injury in vitro
25. Induction of antenatal penventricular leukomalacia by hemorrhagic hypotension in the chronically instrumented fetal sheep
26. Glutamate receptor-mediated toxicity m optic nerve oligodendrocytes
27. Oligodendrocytes from forebrain are highly vulnerable to AMPA/kainate receptor-mediated excitotoxicity
28. 2+-permeable AMPA receptors in cortical glia
29. Neuroprotection after several days of mild, drug-induced hypothermia
30. Vulnerability of oligodendroglia to glutamate: Pharmacology mechanisms, and prevention
31. Magnetic resonance imaging of periventricular leukomalacia and its clinical correlation in children
32. White matter necrosis in very low birth weight infants: Neuropathologic and ultrasonographic findings in infants surviving six days or longer
33. Glial cells of the oligodendrocyte lineage express both kainate- and AMPA-preferring subtypes of glutamate receptor
34. Differential expression of three glutamate receptor genes in developing rat brain: An in situ hybridization study
35. Light and electron immunocytochemical localization of AMPA-selective glutamate receptors in the rat brain
36. Glutamate excitotoxicity in a model of multiple sclerosis
37. Maturational change in the cortical response to hypoperfusion injury in the fetal sheep
38. The influence of immaturity on hypoxic-ischemic brain damage in the rat
39. Anatomical features of the developing brain implicated in pathogenesis of hypoxic-ischemic injury
40. Glutamate release in severe brain ischaemia is mainly by reversed uptake
41. A rat model for hypoxicischemic brain damage in very premature infants
42. Hypoxia-ischemia stimulates hippocampal glutamate efflux in perinatal rat brain: An in vivo microdialysis study
43. Cerebral magnetic resonance imaging and mental and motor function of very low birth weight children at six years of age
44. Neuropatholiogy of remote hypoxic-ischemic damage in the immature rat
45. Effect of unilateral perinatal hypoxic-ischemic brain damage on the gross development of opposite cerebral hemisphere
46. A new model of white matter injury in neonatal rats with bilateral carotid artery occlusion
47. Brain injury in the premature infant: From pathogenesis to prevention
48. A new method to detect apoptosis in paraffin section: In situ end-labeling of fragmented DNA
49. Influence of mild hypothermia on hypoxic-ischemic brain damage in the immature rat
50. α-Amino-3-hydroxy-5-methyl-4-isoxazoleproprionate (AMPA) receptors mediate excitotoxicity in the oligodendroglial lineage
51. Pathophysiology of oligodendroglial excitotoxicity
52. The effect of graded hypothermia on hypoxic-ischemic brain damage: A neuropathologic study in the neonatal rat
53. Apoptosis and necrosis in the newborn piglet brain following transient cerebral hypoxia-ischemia