Enteropathogenic Escherichia coli (EPEC) - A crafty subversive little bug

Microbiology

Volumn 148, Issue 7, 2002, Pages 1967-1978

  Kenny, Brendan ^a  

^a SCHOOL OF MEDICAL SCIENCES   (United Kingdom)

Author keywords

Actin; Cdc42; Map; Phosphorylation; Signalling

Indexed keywords

ALPHA ACTININ; BACTERIAL PROTEIN; CHAPERONE; COFILIN; CORTACTIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOSKELETON PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; INTIMIN; LIPOCORTIN; OUTER MEMBRANE PROTEIN; PROTEIN CDC42; REGULATOR PROTEIN; SERINE; TALIN; TROPOMYOSIN; TYROSINE; VEROTOXIN; VINCULIN; ZYXIN;

BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERIUM ADHERENCE; BACTERIUM CONTAMINATION; CELL MEMBRANE; CONTROLLED STUDY; DIARRHEA; DISEASE TRANSMISSION; ESCHERICHIA COLI; ESCHERICHIA COLI O157; FILOPODIUM; GENE EXPRESSION REGULATION; HOST CELL; HOST RANGE; INFECTION SENSITIVITY; MOLECULAR CLONING; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REVIEW;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0036064379     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-148-7-1967     Document Type: Review

References (77)

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3. Enterohemorrhagic Escherichia coli induces apoptosis which augments bacterial binding and phosphatidylethanolamine exposure on the plasma membrane outer leaflet
4. Structural basis for recognition of the translocated intimin receptor (Tir) by intimin from enteropathogenic Escherichia coli
5. Rho GTPases and their effector proteins
6. New EMBO members' review: Viral and bacterial proteins regulating apoptosis at the mitochondrial level
7. Talin, a host cell protein, interacts directly with the translocated intimin receptor, Tir, of enteropathogenic Escherichia coli, and is essential for pedestal formation
8. Host cell death due to enteropathogenic Escherichia coli has features of apoptosis
9. Coiled-coil domain of enteropathogenic Escherichia coli type III secreted protein EspD is involved in EspA filament-mediated cell attachment and hemolysis
10. Identification of the intimin-binding domain of Tir of enteropathogenic Escherichia coli
11. Enterohemorrhagic Escherichia coli O157:H7 produces Tir, which is translocated to the host cell membrane but is not tyrosine phosphorylated
12. Tir tyrosine phosphorylation and pedestal formation are delayed in enteropathogenic Escherichia coli sepZ:: TnphoA mutant 30-5-1(3)
13. Construction and analysis of TnphoA mutants of enteropathogenic Escherichia coli unable to invade HEp-2 cells
14. Role of the eaeA gene in experimental enteropathogenic Escherichia coli infection
15. The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia coli E2348/69
16. The cloned locus of enterocyte effacement from enterohemorrhagic Escherichia coli O157:H7 is unable to confer the attaching and effacing phenotype upon E. coli K-12
17. Identification of CesT, a chaperone for the type III secretion of Tir in enteropathogenic Escherichia coli
18. EspG, a novel type III system-secreted protein from enteropathogenic Escherichia coli with similarities to VirA of Shigella flexneri
19. Multiple roles for Cdc42 in cell regulation
20. The biological functions of A-kinase anchor proteins
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24. SopE and SopE2 from Salmonella typhimurium activate different sets of RhoGTPases of the host cell
25. Hierarchy in the expression of the locus of enterocyte effacement genes of enteropathogenic Escherichia coli
26. Gut feelings: Enteropathogenic E. coli (EPEC) interactions with the host
27. Enteropathogenic E. coli translocated intimin receptor, Tir, interacts directly with alpha-actinin
28. Recruitment of cytoskeletal and signaling proteins to enteropathogenic and enterohemorrhagic Escherichia coli pedestals
29. Enteropathogenic E. coli Tir binds Nck to initiate actin pedestal formation in host cells
30. Rho GTPases and the actin cytoskeleton
31. Binding of intimin from enteropathogenic Escherichia coli to Tir and to host cells
32. Decreased apoptosis in the ileum and ileal Peyer's patches: A feature after infection with rabbit enteropathogenic Escherichia coli O103
33. Type III protein secretion systems in bacterial pathogens of animals and plants
34. Characterization of translocation pores inserted into plasma membranes by type III-secreted Esp proteins of enteropathogenic Escherichia coli
35. Enteropathogenic Escherichia coli contains a putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation
36. A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells
37. Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals
38. EPEC delivers the goods
39. Phosphorylation of tyrosine 474 of the enteropathogenic Escherichia coli (EPEC) Tir receptor molecule is essential for actin nucleating activity and is preceded by additional host modifications
40. The enterohaemorrhagic Escherichia coli (serotype O157:H7) Tir molecule is not functionally interchangeable for its enteropathogenic E. coli (serotype O127:H6) homologue
41. Protein secretion by enteropathogenic Escherichia coli is essential for transducing signals to epithelial cells
42. Intimin-dependent binding of enteropathogenic Escherichia coli to host cells triggers novel signaling events, including tyrosine phosphorylation of phospholipase C gamma
43. Targeting of an enteropathogenic E. coli (EPEC) effector protein to host mitochondria
44. Enteropathogenic Escherichia coli (EPEC) Tir receptor molecule does not undergo full modification when introduced into host cells by EPEC-independent mechanisms
45. EspA, a protein secreted by enteropathogenic Escherichia coli, is required to induce signals in epithelial cells
46. Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells
47. Co-ordinate regulation of distinct host cell signalling pathways by multifunctional enteropathogenic E. coli (EPEC) effector molecules
48. Adhesion of enteropathogenic Escherichia coli to human intestinal enterocytes and cultured human intestinal mucosa
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50. A novel EspA-associated surface organelle of enteropathogenic Escherichia coli involved in protein translocation into epithelial cells
51. Supramolecular structure of the Salmonella typhimurium type III protein secretion system
52. Crystal structure of enteropathogenic Escherichia coli intimin-receptor complex
53. Role of tir and intimin in the virulence of rabbit enteropathogenic Escherichia coli serotype O103:H2
54. A cloned pathogenicity island from enteropathogenic Escherichia coli confers the attaching and effacing phenotype on E. coli K-12
55. A genetic locus of enterocyte effacement conserved among diverse enterobacterial pathogens
56. Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function
57. Attaching and effacing activities of rabbit and human enteropathogenic Escherichia coli in pig and rabbit intestines
58. Diarrheagenic Escherichia coli
59. Translocated intimin receptors (Tir) of Shiga-toxigenic Escherichia coli isolates belonging to serogroups O26, O111, and O157 react with sera from patients with hemolytic-uremic syndrome and exhibit marked sequence heterogeneity
60. Molecular evolution of a pathogenicity island from enterohemorrhagic Escherichia coli O157:H7
61. Genome sequence of enterohaemorrhagic Escherichia coli O157:H7
62. Signal transduction between enteropathogenic Escherichia coli (EPEC) and epithelial cells: EPEC induces tyrosine phosphorylation of host cell proteins to initiate cytoskeletal rearrangement and bacterial uptake
63. A pathogenic bacterium triggers epithelial signals to form a functional bacterial receptor that mediates actin pseudopod formation
64. GTPase-activating proteins: Helping hands to complement an active site
65. Supermolecular structure of the enteropathogenic Escherichia coli type III secretion system and its direct interaction with the EspA-sheath-like structure
66. EspA filament-mediated protein translocation into red blood cells
67. Identification of SopE2 from Salmonella typhimurium, a conserved guanine nucleotide exchange factor for Cdc42 of the host cell
68. The EspB protein of enteropathogenic Escherichia coli is targeted to the cytoplasm of infected HeLa cells
69. Expression of the EspB protein of enteropathogenic Escherichia coli within HeLa cells affects stress fibers and cellular morphology
70. IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells
71. Exploitation of host cells by enteropathogenic Escherichia coli
72. Insertion of EspD into epithelial target cell membranes by infecting enteropathogenic Escherichia coli
73. Phosphoserine modification of the enteropathogenic E. coli Tir molecule is required to trigger conformational changes and efficient pedestal elongation
74. Type III secretion-dependent hemolytic activity of enteropathogenic Escherichia coli
75. Role of EscF, a putative needle complex protein, in the type III protein translocation system of enteropathogenic Escherichia coli
76. Protein translocation into host epithelial cells by infecting enteropathogenic Escherichia coli
77. Complete nucleotide sequence and analysis of the locus of enterocyte effacement from rabbit diarrheagenic Escherichia coli RDEC-1