Co-ordinate regulation of distinct host cell signalling pathways by multifunctional enteropathogenic Escherichia coli effector molecules

Molecular Microbiology

Volumn 44, Issue 4, 2002, Pages 1095-1107

  Kenny, Brendan ^a   Ellis, Sarah ^b   Leard, Alan D ^b   Warawa, Jonathan ^a   Mellor, Harry ^b   Jepson, Mark A ^b  

^a Dept Anat Sch Med Sci U   (United Kingdom)

^b SCHOOL OF MEDICAL SCIENCES   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; INTIMIN; PROTEIN CDC42; PROTEIN MAP; PROTEIN TIR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CYTOSKELETON; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN REGULATION; EFFECTOR CELL; ESCHERICHIA COLI; FILOPODIUM; HELA CELL; HOST CELL; HUMAN; HUMAN CELL; MOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF;

ACTINS; ADHESINS, BACTERIAL; BACTERIAL ADHESION; CARRIER PROTEINS; CDC42 GTP-BINDING PROTEIN; CYTOSKELETON; DIARRHEA; DOWN-REGULATION; EPITHELIAL CELLS; ESCHERICHIA COLI; ESCHERICHIA COLI INFECTIONS; ESCHERICHIA COLI PROTEINS; HELA CELLS; HUMANS; MODELS, BIOLOGICAL; PROTEIN BINDING; PSEUDOPODIA; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; NEGIBACTERIA;

EID: 0036096793     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.2002.02952.x     Document Type: Article

References (50)

1. Enteropathogenic Escherichia coli translocated intimin receptor. Tir, requires a specific chaperone for stable secretion
2. Agents that inhibit Rho, Rac, and Cdc42 do not block formation of actin pedestals in HeLa cells infected with enteropathogenic Escherichia coli
3. Rho GTPases and their effector proteins
4. Small GTP binding proteins and bacterial virulence
5. The virulence plasmid pWR100 and the repertoire of proteins secreted by the type III secretion apparatus of Shigella flexneri
6. Assembly and function of type III secretory systems
7. Construction and analysis of TnphoA mutants of enteropathogenic Escherichia coli unable to invade HEp-2 cells
8. Role of the eaeA gene in experimental enteropathogenic Escherichia coli infection
9. A second chromosomal gene necessary for intimate attachment of enteropathogenic Escherichia coli to epithelial cells
10. The complete sequence of the locus of enterocyte effacement (LEE) from enteropathogenic Escherichia coli E2348/69
11. Identification of CesT, a chaperone for the type III secretion of Tir in enteropathogenic Escherichia coli
12. EspG, a novel type III system-secreted protein from enteropathogenic Escherichia coli with similarities to VirA of Shigella flexneri
13. Multiple roles for Cdc42 in cell regulation
14. The eaeB gene of enteropathogenic Escherichia coli is necessary for signal transduction in epithelial cells
15. Enteropathogenic and enterohaemorrhagic Escherichia coli: More subversive elements
16. A salmonella protein antagonizes Rac-1 and Cdc42 to mediate host-cell recovery after bacterial invasion
17. A simple method for the acquisition of high-quality digital images from analog scanning electron microscopes
18. The N-terminal domain of Pseudomonas aeruginosa exoenzyme S is a GTPase-activating protein for Rho GTPases
19. Rho GTPases and the actin cytoskeleton
20. Type III protein secretion systems in bacterial pathogens of animals and plants
21. Enteropathogenic E. coli acts through WASP and Arp2/3 complex to form actin pedestals
22. Phosphorylation of tyrosine 474 of the enteropathogenic Escherichia coli (EPEC) Tir receptor molecule is essential for actin nucleating activity and is preceded by additional host modifications
23. The enterohaemorrhagic Escherichia coli (serotype O157:H7) Tir molecule is not functionally interchangeable for its enteropathogenic E. coli (serotype O127:H6) homologue
24. Protein secretion by enteropathogenic Escherichia coli is essential for transducing signals to epithelial cells
25. Intimin-dependent binding of enteropathogenic Escherichia coli to host cells triggers novel signaling events, including tyrosine phosphorylation of phospholipase C gamma
26. Targeting of an enteropathogenic E. coli (EPEC) effector protein to host mitochondria
27. Enteropathogenic Escherichia coli (EPEC) Tir receptor molecule does not undergo full modification when introduced into host cells by EPEC-independent mechanisms
28. EspA, a protein secreted by enteropathogenic Escherichia coli, is required to induce signals in epithelial cells
29. Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells
30. A novel EspA-associated surface organelle of enteropathogenic Escherichia coli involved in protein translocation into epithelial cells
31. The diarrheal response of humans to some classic serotypes of enteropathogenic Escherichia coli is dependent on a plasmid encoding an enteroadhesiveness factor
32. Translocated EspF protein from enteropathogenic Escherichia coli disrupts host intestinal barrier function
33. Role of Tir and intimin in the virulence of rabbit enteropathogenic Escherichia coli serotype O103:H2
34. Attaching and effacing activities of rabbit and human enteropathogenic Escherichia coli in pig and rabbit intestines
35. Rho GTPases control polarity, protrusion, and adhesion during cell movement
36. Molecular evolution of a pathogenicity island from enterohemorrhagic Escherichia coli O157:H7
37. Intimin from enteropathogenic Escherichia coli mediates remodelling of the eukaryotic cell surface
38. Signal transduction between enteropathogenic Escherichia coli (EPEC) and epithelial cells: EPEC induces tyrosine phosphorylation of host cell proteins to initiate cytoskeletal rearrangement and bacterial uptake
39. A pathogenic bacterium triggers epithelial signals to form a functional bacterial receptor that mediates actin pseudopod formation
40. Expression of attaching/effacing activity by enteropathogenic Escherichia coli depends on growth phase, temperature, and protein synthesis upon contact with epithelial cells
41. Biochemical analysis of SopE from Salmonella typhimurium, a highly efficient guanosine nucleotide exchange factor for RhoGT-Pases
42. GTPase-activating proteins: Helping hands to complement an active site
43. Identification of SopE2 from Salmonella typhimurium, a conserved guanine nucleotide exchange factor for Cdc42 of the host cell
44. IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells
45. Exploitation of host cells by enteropathogenic Escherichia coli
46. GAP activity of the Yersinia YopE cytotoxin specifically targets the Rho pathway: A mechanism for disruption of actin microfilament structure
47. Localized adherence by enteropathogenic Escherichia coli is an inducible phenotype associated with the expression of new outer membrane proteins
48. Phosphoserine modification of the enteropathogenic E. coli Tir molecule is required to trigger conformational changes and efficient pedestal elongation
49. Protein translocation into host epithelial cells by infecting enteropathogenic Escherichia coli
50. Complete nucleotide sequence and analysis of the locus of enterocyte effacement from rabbit diarrheagenic Escherichia coli RDEC-1