A pathogenic bacterium triggers epithelial signals to form a functional bacterial receptor that mediates actin pseudopod formation

EMBO Journal

Volumn 15, Issue 11, 1996, Pages 2613-2624

  Rosenshine, Ilan ^a,b   Ruschkowski, Sharon ^b   Stein, Markus ^b   Reinscheid, Dieter J ^b   Mills, Scott D ^b   Finlay, B Brett ^b  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Actin; Diarrhea; Enteropathogenic Escherichia coli; Pathogenesis; Signal transduction

Indexed keywords

ACTIN; ADHESIN;

ARTICLE; CYTOSKELETON; ENTEROBACTERIACEAE; ESCHERICHIA COLI; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PSEUDOPODIUM; SIGNAL TRANSDUCTION;

EID: 0029933731     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb00621.x     Document Type: Article

References (33)

1. Andrade,J.R., Da Veiga,V.F., De Santa Rosa,M.R. and Suassuna,I. (1989) An endocytic process in HEp-2 cells induced by enteropathogenic Escherichia coli. J. Med. Microbiol., 28, 49-57.
2. Cossart,P. and Kocks,C. (1994) The actin-based motility of the facultative intracellular pathogen Listeria monocytogenes. Mol. Microbiol., 13, 395-402.
3. Donnenberg,M.S. and Kaper,J.B. (1991) Construction of an eae deletion mutant of enteropathogenic Escherichia coli by using a positive-selection suicide vector. Infect. Immun., 59, 4310-4317.
4. Donnenberg,M.S. and Kaper,J.B. (1992) Enteropathogenic Escherichia coli. Infect. Immun., 60, 3953-3961.
5. Donnenberg,M.S., Calderwood,S.B., Donohue-Rolfe,A., Keusch,G.T. and Kaper,J.B. (1990a) Construction and analysis of TnphoA mutants of enteropathogenic Escherichia coli unable to invade HEp-2 cells. Infect. Immun., 58, 1565-1571.
6. Donnenberg,M.S., Donohue-Rolfe,A. and Keusch,G.T. (1990b) A comparison of HEp-2 cell invasion by enteropathogenic and enteroinvasive Escherichia coli. FEMS Microbiol. Lett., 57, 83-86.
7. Donnenberg,M.S., Giron,J.A., Nataro,J.P. and Kaper,J.B. (1992) A plasmid-encoded type IV fimbrial gene of enteropathogenic Escherichia coli associated with localized adherence. Mol. Microbiol., 6, 3427-3437.
8. Donnenberg,M.S., Tacket,C.O., James,S.P., Losonsky,G., Nataro,J.P., Wasserman,S.S., Kaper,J.B. and Levine,M.M. (1993a) Role of the eaeA gene in experimental enteropathogenic Escherichia coli infection. J. Clin. Invest., 92, 1412-1417.
9. Donnenberg,M.S., Yu,J. and Kaper,J.B. (1993b) A second chromosomal gene necessary for intimate attachment of enteropathogenic Escherichia coli to epithelial cells. J. Bacteriol., 175, 4670-4680.
10. Dytoc,M., Fedorko,L. and Sherman,P.M. (1994) Signal transduction in human epithelial cells infected with attaching and effacing Escherichia coli in vitro. Gastroenterology, 106, 1150-1161.
11. Finlay,B.B., Ruschkowski,S. and Dedhar,S. (1991) Cytoskeletal rearrangements accompanying Salmonella entry into epithelial cells. J. Cell Sci., 99, 283-296.
12. Finlay,B.B., Rosenshine,I., Donnenberg,M.S. and Kaper,J.B. (1992) Cytoskeletal composition of attaching and effacing lesions associated with enteropathogenic Escherichia coli adherence to HeLa cells. Infect. Immun., 60, 2541-2543.
13. Foubister,V., Rosenshine,I. and Finlay,B.B. (1994a) A diarrheal pathogen, enteropathogenic Escherichia coli (EPEC). triggers a flux of inositol phosphates in infected epithelial cells. J. Exp. Med., 179, 993-998.
14. Foubister,V., Rosenshine,I., Donnenberg,M.S. and Finlay,B.B. (1994b) The eaeB gene of enteropathogenic Escherichia coli is necessary for signal transduction in epithelial cells. Infect. Immun., 62, 3038-3040.
15. Frankel,G., Candy,D.C., Everest,P., and Dougan,G. (1994) Characterization of the C-terminal domains of intimin-like proteins of enteropathogenic and enterohemorrhagic Escherichia coli, Citrobacter freundii, and Hafnia alvei. Infect. Immun., 62, 1835-1842.
16. Giron,J.A., Ho,A.S. and Schoolnik,G.K. (1993) Characterization of fimbriae produced by enteropathogenic Escherichia coli. J. Bacteriol., 175, 7391-403.
17. Hildebrand,J.D., Schaller,M.D. and Parsons,J.T. (1995) Paxillin, a tryosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase. Mol. Biol. Cell, 6, 637-647.
18. Isberg,R.R. and Leong,J.M. (1990) Multiple β1 chain integrins are receptors for invasin, a protein that promotes bacterial penetration into mammalian cells. Cell, 60, 861-871.
19. Isberg,R.R., Voorhis,D.L. and Falkow,S. (1987) Identification of invasin: a protein that allows enteric bacteria to penetrate cultured mammalian cells. Cell, 50, 769-778.
20. Jarvis,K.G., Giron,J.A., Jerse,A.E., McDaniel,T.K., Donnenberg,M.S. and Kaper,J.B. (1995) Enteropathogenic Escherichia coli contains a putative type III secretion system necessary for the export of proteins involved in attaching and effacing lesion formation. Proc. Natl Acad. Sci. USA, 92, 7996-8000.
21. Jerse,A.E., Yu,J., Tall,B.D. and Kaper,J.B. (1990) A genetic locus of enteropathogenic Escherichia coli necessary for the production of attaching and effacing lesions on tissue culture cells. Proc. Natl Acad. Sci. USA, 87, 7839-7843.
22. Kenny,B. and Finlay,B.B. (1995) Protein secretion by enteropathogenic Escherichia coli is essential for transducing signals to epithelial cells. Proc. Natl Acad. Sci. USA, 92, 7991-7995.
23. Knutton,S., Baldwin,T., Williams,P.H. and McNeish,A.S. (1989) Actin accumulation at sites of bacterial adhesion to tissue culture cells: basis of a new diagnostic test for enteropathogenic and enterohemorrhagic Escherichia coli. Infect. Immun., 57, 1290-1298.
24. Labigne-Roussel,A., Schmidt,M.A., Walz,W. and Falkow,S. (1985) Genetic organization of the afimbrial adhesin operon and nucleotide sequence from a uropathogenic Escherichia coli gene encoding an afimbrial adhesin. J. Bacteriol., 162, 1285-1292.
25. Levine,M.M. and Edelman,R. (1984) Enteropathogenic Escherichia coli of classic serotypes associated with infant diarrhea: epidemiology and pathogenesis. Epidemiol. Rev., 6, 31-51.
26. Lo,S.H. and Chen,L.B. (1994) Focal adhesion as a signal transduction organelle. Cancer Metastasis Rev., 13, 9-24.
27. Manjarrez-Hernandez,H.A., Baldwin,T.J., Aitken,A., Knutton,S. and, Williams,P.H. (1992) Intestinal epithelial cell protein phosphorylation in enteropathogenic Escherichia coli diarrhoea. Lancet, 339, 521-523.
28. Otey,C.A. and Burridge,K. (1990) Patterning of the membrane cytoskeleton by the extracellular matrix. Semin. Cell Biol., 1, 391-399.
29. Rosenshine,L., Donnenberg,M.S., Kaper,J.B. and Finlay,B.B. (1992) Signal transduction between enteropathogenic Escherichia coli (EPEC) and epithelial cells: EPEC induces tyrosine phosphorylation of host cell proteins to initiate cytoskeletal rearrangement and bacterial uptake. EMBO J., 11, 3551-3560.
30. Rosqvist,R., Magnusson,K.E. and Wolf-Watz,H. (1994) Target cell contact triggers expression and polarized transfer of Yersinia YopE cytotoxin into mammalian cells. EMBO J., 13, 964-972.
31. Sory,M.P. and Cornelis,G.R. (1994) Translocation of a hybrid YopE-adenylate cyclase from Yersinia enterocolitica into HeLa cells. Mol. Microbiol., 14, 583-594.
32. Tang,P., Foubister,V., Graciela Pucciarelli,M. and Finlay,B.B. (1993) Method to study bacterial invasion. J. Micro Methods, 18, 227-240.
33. Young,V.B., Miller,V.L., Falkow,S. and Schoolnik,G.K. (1990) Sequence, localization and function of the invasin protein of Yersinia enterocolitica. Mol. Microbiol., 4, 1119-1128.