The TGF-β2 isoform is both a required and sufficient inducer of murine hair follicle morphogenesis

Developmental Biology

Volumn 212, Issue 2, 1999, Pages 278-289

  Foitzik, Kerstin ^a   Paus, Ralf ^b   Doetschman, Tom ^c   Paolo Dotto, G ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b HUMBOLDT UNIVERSITY   (Germany)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Development; Differentiation; Hair follicle; Keratinocyte; Ki 67; Transforming growth factor

Indexed keywords

KI 67 ANTIGEN; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3; ISOPROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; EPIDERMIS HYPERPLASIA; GENE DISRUPTION; HAIR FOLLICLE; HAIR GROWTH; KERATINOCYTE; MORPHOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN CULTURE; ANIMAL; COMPARATIVE STUDY; EMBRYO INDUCTION; EPIDERMIS; GENETICS; METABOLISM; MOUSE MUTANT; ORGAN CULTURE TECHNIQUE; PRENATAL DEVELOPMENT;

ANIMALIA; MAMMALIA; MURINAE;

ANIMALS; EMBRYONIC INDUCTION; EPIDERMIS; HAIR FOLLICLE; MICE; MICE, MUTANT STRAINS; MORPHOGENESIS; ORGAN CULTURE TECHNIQUES; PROTEIN ISOFORMS; TRANSFORMING GROWTH FACTOR BETA;

EID: 0033566365     PISSN: 00121606     EISSN: None     Source Type: Journal    
DOI: 10.1006/dbio.1999.9325     Document Type: Article

References (40)

1. Baker J. C., Harland R. M. From receptor to nucleus: The Smad pathway. Curr. Opin. Genet. Dev. 7:1997;467-473.
2. Calautti E., Missero C., Stein P. L., Ezzell R. M., Dotto G. P. fyn tyrosine kinase is involved in keratinocyte differentiation control. Genes Dev. 9:1995;2279-2291.
3. Clark D. A., Coker R. Transforming growth factor-beta (TGF-beta). Int. J. Biochem. Cell. Biol. 30:1998;293-298.
4. Gat U., DasGupta R., Degenstein L., Fuchs E. De novo hair follicle morphogenesis and hair tumors in mice expressing a truncated β-catenin in the skin. Cell. 95:1998;605-614.
5. Glick A. B., Lee M. M., Darwiche N., Kulkarni A. B., Karlsson S., Yuspa S. H. Targeted deletion of the TGF-beta 1 gene causes rapid progression to squamous cell carcinoma. Genes Dev. 8:1994;2429-2440.
6. Gurdon J. B., Harger P., Mitchell A., Lemaire P. Activin signalling, a response to a morphogen gradient. Nature. 371:1994;487-492.
7. Hansen L. S., Coggle J. E., Wells J., Charles M. W. The influence of the hair cycle on the thickness of mouse skin. Anat. Rec. 210:1984;569-573.
8. Hardy M. H. The secret life of the hair follicle. Trends Genet. 8:1992;55-61.
9. Heine U., Munoz E. F., Flanders K. C., Ellingsworth L. R., Lam H. Y., Thompson N. L., Roberts A. B., Sporn M. B. Role of transforming growth factor-beta in the development of the mouse embryo. J. Cell Biol. 105:1987;2861-2876.
10. Hogan B. L. Bone morphogenetic proteins in development. Curr. Opin. Genet. Dev. 6:1996;432-438.
11. Hoodless P. A., Wrana J. L. Mechanism and function of signaling by the TGF beta superfamily. Curr. Top. Microbiol. Immunol. 228:1998;235-272.
12. Jung H. S., Francis-West P. H., Widelitz R. B., Jiang T. X., Ting-Berreth S., Tickle C., Wolpert L., Chuong C. M. Local inhibitory action of BMPs and their relationships with activators in feather formation: Implications for periodic patterning. Dev. Biol. 196:1998;11-23.
13. Kaartinen V., Voncken J. W., Shuler C., Warburton D., Bu D., Heisterkamp N., Groffen J. Abnormal lung development and cleft palate in mice lacking TGF-beta 3 indicate defects of epithelial-mesenchymal interaction. Nat. Genet. 11:1995;415-421.
14. Kingsley D. M. The TGF-beta superfamily: New members, new receptors, and new genetic tests of function in different organisms. Genes Dev. 8:1994;133-146.
15. Kratochwil K., Dull M., Farinas I., Galceran J., Grosschedl R. Lef1 expression is activated by BMP-4 and regulates inductive tissue interactions in tooth and hair development. Genes Dev. 10:1996;1382-1394.
16. Kulkarni A. B., Huh C. G., Becker D., Geiser A., Lyght M., Flanders K. C., Roberts A. B., Sporn M. B., Ward J. M., Karlsson S. Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. USA. 90:1993;770-774.
17. Letterio J. J., Roberts A. B. Transforming growth factor-beta1-deficient mice: Identification of isoform-specific activities in vivo. J. Leukocyte Biol. 59:1996;769-774.
18. Letterio J. J., Bottinger E. P. TGF-beta knockout and dominant-negative receptor transgenic mice. Miner. Electrolyte Metab. 24:1998;161-167.
19. Massague J., Cheifetz S., Laiho M., Ralph D. A., Weis F. M., Zentella A. Transforming growth factor-beta. Cancer Surv. 12:1992;81-103.
20. Massague J. TGF-beta signal transduction. Annu. Rev. Biochem. 67:1998;753-791.
21. Millan F. A., Denhez F., Kondaiah P., Akhurst R. J. Embryonic gene expression patterns of TGF beta 1, beta 2 and beta 3 suggest different developmental functions in vivo. Development. 111:1991;131-143.
22. Morgan B. A., Orkin R. W., Noramly S., Perez A. Stage-specific effects of sonic hedgehog expression in the epidermis. Dev. Biol. 201:1998;1-12.
23. Moses H. L., Serra R. Regulation of differentiation by TGF-beta. Curr. Opin. Genet. Dev. 6:1996;581-586.
24. Oro A. E., Scott M. P. Splitting hairs: Dissecting roles of signaling systems in epidermal development. Cell. 95:1998;575-578.
25. Paus R., Stenn K. S., Link R. E. Telogen skin contains an inhibitor of hair growth. Br. J. Dermatol. 122:1990;777-784.
26. Paus R., Foitzik K., Welker P., Bulfone-Paus S., Eichmuller S. Transforming growth factor-beta receptor type I and type II expression during murine hair follicle development and cycling. J. Invest. Dermatol. 109:1997;518-526.
27. Pelton R. W., Nomura S., Moses H. L., Hogan B. L. Expression of transforming growth factor beta 2 RNA during murine embryogenesis. Development. 106:1989;759-767.
28. Pelton R. W., Saxena B., Jones M., Moses H. L., Gold L. I. Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo: Expression patterns suggest multiple roles during embryonic development. J. Cell Biol. 115:1991;1091-1105.
29. Philpott M. P., Sanders D., Westgate G. E., Kealey T. Human hair growth in vitro: A model for the study of hair follicle biology. J. Dermatol. Sci. 7:1994;S55-S72.
30. Philpott M. P., Paus R. Hair follicle morphogenesis. CM C. Molecular Biology of Epithelial Appendages Morphogenesis. 1998;Landes Bioscience, Austin.
31. Proetzel G., Pawlowski S. A., Wiles M. V., Yin M., Boivin G. P., Howles P. N., Ding J., Ferguson M. W., Doetschman T. Transforming growth factor-beta 3 is required for secondary palate fusion. Nat, Genet. 11:1995;409-414.
32. Roberts A. B., Flanders K. C., Heine U. I., Jakowlew S., Kondaiah P., Kim S. J., Sporn M. B. Transforming growth factor-beta: Multifunctional regulator of differentiation and development. Philos. Trans. R. Soc. London B Biol. Sci. 327:1990;145-154.
33. Sanford L. P., Ormsby I., Gittenberger-de Groot A. C., Sariola H., Friedman R., Boivin G. P., Cardell E. L., Doetschman T. TGFbeta2 knockout mice have multiple developmental defects that are non-overlapping with other TGFbeta knockout phenotypes. Development. 124:1997;2659-2670.
34. Sellheyer K., Bickenbach J. R., Rothnagel J. A., Bundman D., Longley M. A., Krieg T., Roche N. S., Roberts A. B., Roop D. R. Inhibition of skin development by overexpression of transforming growth factor beta 1 in the epidermis of transgenic mice. Proc. Natl. Acad. Sci. USA. 90:1993;5237-5241.
35. Shull M. M., Ormsby I., Kier A. B., Pawlowski S., Diebold R. J., Yin M., Allen R., Sidman C., Proetzel G., Calvin D. Targeted disruption of the mouse transforming growth factor-beta 1 gene results in multifocal inflammatory disease. Nature. 359:1992;693-699.
36. Stenn K. S., Combates N. J., Eilertsen K. J., Gordon J. S., Pardinas J. R., Parimoo S., Prouty S. M. Hair follicle growth controls. Dermatol. Clin. 14:1996;543-558.
37. St-Jacques B., Dassule H. R., Karavanova I., Botchkarev V. A., Li J., Danielian P. S., McMahon J. A., Lewis P. M., Paus R., McMahon A. P. Sonic hedgehog signaling is essential for hair development. Curr. Biol. 8:1998;1058-1068.
38. Thesleff I., Vaahtokari A., Vainio S., Jowett A. Molecular mechanisms of cell and tissue interactions during early tooth development. Anat. Rec. 245:1996;151-161.
39. Ting-Berreth S. A., Chuong C. M. Local delivery of TGF beta2 can substitute for placode epithelium to induce mesenchymal condensation during skin appendage morphogenesis. Dev. Biol. 179:1996a;347-359.
40. Ting-Berreth S. A., Chuong C. M. Sonic hedgehog in feather morphogenesis: Induction of mesenchymal condensation and association with cell death. Dev. Dyn. 207:1996b;157-170.