The microcystins and nodularins: Cyclic polypeptide inhibitors of PP1 and PP2A

Current Medicinal Chemistry

Volumn 9, Issue 22, 2002, Pages 1991-2003

  Gulledge, B M ^a   Aggen, J B ^a   Huang, H B ^a   Nairn, A C ^a   Chamberlin, A R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOGINOSIN; CYANOGINOSIN DERIVATIVE; CYANOGINOSIN LR; CYANOGINOSIN XZ; MOTUPORIN; NATURAL PRODUCT; NODULARIN; NODULARIN DERIVATIVE; NODULARIN Z; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE 1; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; POLYPEPTIDE; PROTEIN SERINE THREONINE PHOSPHATASE; TOXIN; UNCLASSIFIED DRUG; CYCLOPEPTIDE;

BIOSYNTHESIS; CONTROLLED STUDY; CYANOGINOSIN LA; DRUG ISOLATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME BINDING; ENZYME INHIBITION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REVIEW; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG ANTAGONISM; HUMAN; IC 50; SYNTHESIS;

HUMANS; INHIBITORY CONCENTRATION 50; MICROCYSTINS; PEPTIDES, CYCLIC; PHOSPHOPROTEIN PHOSPHATASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036035538     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867023368845     Document Type: Review

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53. 6 + (M+Na)+: 552.3052. Found: 552.3049.
54. 6 + (M+H)+: 666.4485. Found: 666.4496.
55. 5 (M+H)+: 445.2702. Found: 445.2694.
56. 5 (M+Na)+: 453. Found: 453.
57. 5