A molecular modeling analysis of the binding interactions between the okadaic acid class of natural product inhibitors and the Ser-Thr phosphatases, PP1 and PP2A

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 9, 1997, Pages 1751-1773

  Gauss, Carla Maria ^a   Sheppeck II, James E ^a   Nairn, Angus C ^b   Chamberlin, Richard ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALYCULIN A; CANTHARIDIN; CYANOGINOSIN; NATURAL PRODUCT; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; TAUTOMYCIN;

ARTICLE; ATOM; COMPUTER MODEL; CONFORMATION; ENZYME BINDING; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HUMAN; MOLECULAR MODEL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN BINDING; SEQUENCE HOMOLOGY, AMINO ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0030880550     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)00145-4     Document Type: Article

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