Inhibition of protein phosphatase 2A by cyclic peptides modelled on the microcystin ring

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 17, 1996, Pages 2113-2116

  Taylor, Cherie ^a   Quinn, Ronald J ^a   Suganuma, Masami ^b   Fujiki, Hirota ^b  

^a GRIFFITH UNIVERSITY   (Australia)

^b SAITAMA CANCER CENTER   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYANOGINOSIN LR; CYCLOPEPTIDE; ENZYME INHIBITOR; NODULARIN; PHOSPHOPROTEIN PHOSPHATASE;

ARTICLE; ENZYME BINDING; ENZYME INHIBITION; STRUCTURE ACTIVITY RELATION;

EID: 0030567859     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0960-894X(96)00378-2     Document Type: Article

References (10)

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2. Quinn, R. J.; Taylor, C.; Suganuma, M.; Fujiki, H. Bioorg. Med. Chem. Lett., 1993, 3, 1029.
3. Namikoshi, M.; Rinehart, K. L.; Dahlem, A. M.; Beasley, V. R.; Carmichael, W.W. Tetrahedron Lett., 1989, 30, 4349.
4. Abdel-Rahmen, S.; El-Ayouty, Y. M.; Kamael, H. A. Int. J. Peptide Protein Res., 1993, 41, 1.
5. Taylor, C.; Quinn, R. J.; Alewood, P. Bioorg. Med. Chem. Lett., 1996, previous paper.
6. Nishiwaki-Matsushima, R.; Fujiki, H.; Harada, K.-I.; Taylor, C.; Quinn, R. J. Bioorg. Med. Chem. Lett., 1992, 2, 673.
7. 32P]phosphorylase a.
8. 32P]phosphate into the supernatant after precipitation of protein with 100 mL of ice-cold 50% trichloroacetic acid. After centrifugation an aliquot (150 μL) of supernatant was counted in Amersham Aquasol scintillant. Data was expressed as percent inhibition with respect to a control (absence of competing compound) incubation.
9. Carmichael, W. W.; Eschedor, J. T.; Patterson, G. M. L.; Moore, R. E. Appl. Environ. Microbiol., 1988, 54, 2257.
10. Goldberg, J.; Huang, H.; Kwon, Y.; Greengard, P.; Nairn, A.C.; Kuriyan, J. Nature, 1995, 376, 745.