-
1
-
-
0026575583
-
-
For reviews on signaling pathways, see: (a) Rosen, M. K.; Schreiber, S. L. Angew. Chem., Int. Ed. Engl. 1992, 31, 384. (b) Schreiber, S. L.; Liu, J.; Albers, M. W.; Karmacharya, R.; Koh, E.; Martin, P. K.; Rosen, M. K.; Standaert, R. F.; Wandless, T. J. Transplant. Proc. 1991, 23, 2839. (c) Berridge, M. Bioessays 1995, 17, 491. (d) Magee, A. I. Cellular Signal. 1995, 165. (e) Langdon, S. P.; Smyth, J. F. Cancer Treat. Rev. 1995, 21, 65. (f) Edwards, D. R. TIPS 1994, 15, 239. (g) Elmoatassim, C.; Dornand, J.; Mani, J. C. Biochim. Biophvs. Acta 1992, 1134, 31. (h) Sun, H.; Tonks, N. K. TIBS 1994, 19, 480.
-
(1992)
Angew. Chem., Int. Ed. Engl.
, vol.31
, pp. 384
-
-
Rosen, M.K.1
Schreiber, S.L.2
-
2
-
-
0026336396
-
-
For reviews on signaling pathways, see: (a) Rosen, M. K.; Schreiber, S. L. Angew. Chem., Int. Ed. Engl. 1992, 31, 384. (b) Schreiber, S. L.; Liu, J.; Albers, M. W.; Karmacharya, R.; Koh, E.; Martin, P. K.; Rosen, M. K.; Standaert, R. F.; Wandless, T. J. Transplant. Proc. 1991, 23, 2839. (c) Berridge, M. Bioessays 1995, 17, 491. (d) Magee, A. I. Cellular Signal. 1995, 165. (e) Langdon, S. P.; Smyth, J. F. Cancer Treat. Rev. 1995, 21, 65. (f) Edwards, D. R. TIPS 1994, 15, 239. (g) Elmoatassim, C.; Dornand, J.; Mani, J. C. Biochim. Biophvs. Acta 1992, 1134, 31. (h) Sun, H.; Tonks, N. K. TIBS 1994, 19, 480.
-
(1991)
Transplant. Proc.
, vol.23
, pp. 2839
-
-
Schreiber, S.L.1
Liu, J.2
Albers, M.W.3
Karmacharya, R.4
Koh, E.5
Martin, P.K.6
Rosen, M.K.7
Standaert, R.F.8
Wandless, T.J.9
-
3
-
-
0029314844
-
-
For reviews on signaling pathways, see: (a) Rosen, M. K.; Schreiber, S. L. Angew. Chem., Int. Ed. Engl. 1992, 31, 384. (b) Schreiber, S. L.; Liu, J.; Albers, M. W.; Karmacharya, R.; Koh, E.; Martin, P. K.; Rosen, M. K.; Standaert, R. F.; Wandless, T. J. Transplant. Proc. 1991, 23, 2839. (c) Berridge, M. Bioessays 1995, 17, 491. (d) Magee, A. I. Cellular Signal. 1995, 165. (e) Langdon, S. P.; Smyth, J. F. Cancer Treat. Rev. 1995, 21, 65. (f) Edwards, D. R. TIPS 1994, 15, 239. (g) Elmoatassim, C.; Dornand, J.; Mani, J. C. Biochim. Biophvs. Acta 1992, 1134, 31. (h) Sun, H.; Tonks, N. K. TIBS 1994, 19, 480.
-
(1995)
Bioessays
, vol.17
, pp. 491
-
-
Berridge, M.1
-
4
-
-
10544248335
-
-
For reviews on signaling pathways, see: (a) Rosen, M. K.; Schreiber, S. L. Angew. Chem., Int. Ed. Engl. 1992, 31, 384. (b) Schreiber, S. L.; Liu, J.; Albers, M. W.; Karmacharya, R.; Koh, E.; Martin, P. K.; Rosen, M. K.; Standaert, R. F.; Wandless, T. J. Transplant. Proc. 1991, 23, 2839. (c) Berridge, M. Bioessays 1995, 17, 491. (d) Magee, A. I. Cellular Signal. 1995, 165. (e) Langdon, S. P.; Smyth, J. F. Cancer Treat. Rev. 1995, 21, 65. (f) Edwards, D. R. TIPS 1994, 15, 239. (g) Elmoatassim, C.; Dornand, J.; Mani, J. C. Biochim. Biophvs. Acta 1992, 1134, 31. (h) Sun, H.; Tonks, N. K. TIBS 1994, 19, 480.
-
(1995)
Cellular Signal
, pp. 165
-
-
Magee, A.I.1
-
5
-
-
0028950061
-
-
For reviews on signaling pathways, see: (a) Rosen, M. K.; Schreiber, S. L. Angew. Chem., Int. Ed. Engl. 1992, 31, 384. (b) Schreiber, S. L.; Liu, J.; Albers, M. W.; Karmacharya, R.; Koh, E.; Martin, P. K.; Rosen, M. K.; Standaert, R. F.; Wandless, T. J. Transplant. Proc. 1991, 23, 2839. (c) Berridge, M. Bioessays 1995, 17, 491. (d) Magee, A. I. Cellular Signal. 1995, 165. (e) Langdon, S. P.; Smyth, J. F. Cancer Treat. Rev. 1995, 21, 65. (f) Edwards, D. R. TIPS 1994, 15, 239. (g) Elmoatassim, C.; Dornand, J.; Mani, J. C. Biochim. Biophvs. Acta 1992, 1134, 31. (h) Sun, H.; Tonks, N. K. TIBS 1994, 19, 480.
-
(1995)
Cancer Treat. Rev.
, vol.21
, pp. 65
-
-
Langdon, S.P.1
Smyth, J.F.2
-
6
-
-
0028303137
-
-
For reviews on signaling pathways, see: (a) Rosen, M. K.; Schreiber, S. L. Angew. Chem., Int. Ed. Engl. 1992, 31, 384. (b) Schreiber, S. L.; Liu, J.; Albers, M. W.; Karmacharya, R.; Koh, E.; Martin, P. K.; Rosen, M. K.; Standaert, R. F.; Wandless, T. J. Transplant. Proc. 1991, 23, 2839. (c) Berridge, M. Bioessays 1995, 17, 491. (d) Magee, A. I. Cellular Signal. 1995, 165. (e) Langdon, S. P.; Smyth, J. F. Cancer Treat. Rev. 1995, 21, 65. (f) Edwards, D. R. TIPS 1994, 15, 239. (g) Elmoatassim, C.; Dornand, J.; Mani, J. C. Biochim. Biophvs. Acta 1992, 1134, 31. (h) Sun, H.; Tonks, N. K. TIBS 1994, 19, 480.
-
(1994)
TIPS
, vol.15
, pp. 239
-
-
Edwards, D.R.1
-
7
-
-
0026503973
-
-
For reviews on signaling pathways, see: (a) Rosen, M. K.; Schreiber, S. L. Angew. Chem., Int. Ed. Engl. 1992, 31, 384. (b) Schreiber, S. L.; Liu, J.; Albers, M. W.; Karmacharya, R.; Koh, E.; Martin, P. K.; Rosen, M. K.; Standaert, R. F.; Wandless, T. J. Transplant. Proc. 1991, 23, 2839. (c) Berridge, M. Bioessays 1995, 17, 491. (d) Magee, A. I. Cellular Signal. 1995, 165. (e) Langdon, S. P.; Smyth, J. F. Cancer Treat. Rev. 1995, 21, 65. (f) Edwards, D. R. TIPS 1994, 15, 239. (g) Elmoatassim, C.; Dornand, J.; Mani, J. C. Biochim. Biophvs. Acta 1992, 1134, 31. (h) Sun, H.; Tonks, N. K. TIBS 1994, 19, 480.
-
(1992)
Biochim. Biophvs. Acta
, vol.1134
, pp. 31
-
-
Elmoatassim, C.1
Dornand, J.2
Mani, J.C.3
-
8
-
-
0028149381
-
-
For reviews on signaling pathways, see: (a) Rosen, M. K.; Schreiber, S. L. Angew. Chem., Int. Ed. Engl. 1992, 31, 384. (b) Schreiber, S. L.; Liu, J.; Albers, M. W.; Karmacharya, R.; Koh, E.; Martin, P. K.; Rosen, M. K.; Standaert, R. F.; Wandless, T. J. Transplant. Proc. 1991, 23, 2839. (c) Berridge, M. Bioessays 1995, 17, 491. (d) Magee, A. I. Cellular Signal. 1995, 165. (e) Langdon, S. P.; Smyth, J. F. Cancer Treat. Rev. 1995, 21, 65. (f) Edwards, D. R. TIPS 1994, 15, 239. (g) Elmoatassim, C.; Dornand, J.; Mani, J. C. Biochim. Biophvs. Acta 1992, 1134, 31. (h) Sun, H.; Tonks, N. K. TIBS 1994, 19, 480.
-
(1994)
TIBS
, vol.19
, pp. 480
-
-
Sun, H.1
Tonks, N.K.2
-
9
-
-
0028773477
-
-
For reviews on kinases, see: (a) Serota-Taylor, S.; Radzio-Andzelm, E. Structure 1994, 2, 345. (b) Murray, A. W. Chem. Biol. 1994, 1, 191.
-
(1994)
Structure
, vol.2
, pp. 345
-
-
-
10
-
-
0028675322
-
-
For reviews on kinases, see: (a) Serota-Taylor, S.; Radzio-Andzelm, E. Structure 1994, 2, 345. (b) Murray, A. W. Chem. Biol. 1994, 1, 191.
-
(1994)
Chem. Biol.
, vol.1
, pp. 191
-
-
Murray, A.W.1
-
11
-
-
0024397415
-
-
For a review on protein phosphatases, see: Cohen, P. Annu. Rev. Biochem. 1989, 58, 453.
-
(1989)
Annu. Rev. Biochem.
, vol.58
, pp. 453
-
-
Cohen, P.1
-
13
-
-
0025202272
-
-
(b)Hemmings, H. C. J.; Nairn, A. C.; Elliott, J. I.; Greengard, P. J. Biol. Chem. 1990, 265, 20369.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 20369
-
-
Hemmings, H.C.J.1
Nairn, A.C.2
Elliott, J.I.3
Greengard, P.4
-
14
-
-
0024792262
-
-
For a review on the biological roles of protein phosphatases. see: Cohen, P.; Cohen, P. T. W. J. Biol. Chem. 1989, 264, 21435.
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 21435
-
-
Cohen, P.1
Cohen, P.T.W.2
-
19
-
-
0025181418
-
-
For a recent review, see: Cohen, P.; Holmes, C. F. B.; Tsukitani, Y. TIBS 1990, 15, 98.
-
(1990)
TIBS
, vol.15
, pp. 98
-
-
Cohen, P.1
Holmes, C.F.B.2
Tsukitani, Y.3
-
20
-
-
0025340581
-
-
Ubukata, M.; Cheng, X. C.; Isono, K. J. Chem. Soc., Chem. Commun. 1990, 244.
-
(1990)
J. Chem. Soc., Chem. Commun.
, pp. 244
-
-
Ubukata, M.1
Cheng, X.C.2
Isono, K.3
-
21
-
-
0027050190
-
-
and references cited therein
-
Evans, D. A.; Gage, J. R.; Leighton, J. L. J. Am. Chem. Soc. 1992, 114, 9434, and references cited therein.
-
(1992)
J. Am. Chem. Soc.
, vol.114
, pp. 9434
-
-
Evans, D.A.1
Gage, J.R.2
Leighton, J.L.3
-
22
-
-
37049095866
-
-
(a) Botes, D.; Tuinman, A.; Wessels, P.; Viljoen, C.; Kruger, H.; Williams, D. H.; Santikarn, S.; Smith, R.; Hammond, S. J. Chem. Soc., Perkin Trans. 1 1984, 2311.
-
(1984)
J. Chem. Soc., Perkin Trans. 1
, pp. 2311
-
-
Botes, D.1
Tuinman, A.2
Wessels, P.3
Viljoen, C.4
Kruger, H.5
Williams, D.H.6
Santikarn, S.7
Smith, R.8
Hammond, S.9
-
23
-
-
0002056622
-
-
(b) Painuly, P.; Perez, R.; Fukai, T.; Shimizu, Y. Tetrahedron Lett. 1988, 29, 11.
-
(1988)
Tetrahedron Lett.
, vol.29
, pp. 11
-
-
Painuly, P.1
Perez, R.2
Fukai, T.3
Shimizu, Y.4
-
24
-
-
0024244213
-
-
(c) Watanabe, M. F.; Oishi, S.; Harada, K.; Matsuura, K.; Kawai, H.; Suzuki, M. Toxicon 1988, 26, 1017.
-
(1988)
Toxicon
, vol.26
, pp. 1017
-
-
Watanabe, M.F.1
Oishi, S.2
Harada, K.3
Matsuura, K.4
Kawai, H.5
Suzuki, M.6
-
25
-
-
0028950664
-
-
Takai, A.; Sasaki, K.; Nagai, H.; Mieskes, G.; Isobe, M.; Isons, K.; Yasumoto, T. Biochem. J. 1995, 306, 657.
-
(1995)
Biochem. J.
, vol.306
, pp. 657
-
-
Takai, A.1
Sasaki, K.2
Nagai, H.3
Mieskes, G.4
Isobe, M.5
Isons, K.6
Yasumoto, T.7
-
27
-
-
0027946005
-
-
Matsuzawa, S.; Suzuki, T.; Suzuki, M.; Matsuda, A. FEBS Lett. 1994, 356, 272.
-
(1994)
FEBS Lett.
, vol.356
, pp. 272
-
-
Matsuzawa, S.1
Suzuki, T.2
Suzuki, M.3
Matsuda, A.4
-
28
-
-
0029377372
-
-
The synthesis of an Mdha containing segment of microcystin has been reported: Zetterström, M.; Trogen, L.; Hammarström, L.-G.; Juhlin, L.; Nilsson, B.; Damberg, C., Bartai, T.; Langel, Ü. Acta Chem. Scand. 1995, 49, 696.
-
(1995)
Acta Chem. Scand.
, vol.49
, pp. 696
-
-
Zetterström, M.1
Trogen, L.2
Hammarström, L.-G.3
Juhlin, L.4
Nilsson, B.5
Damberg, C.6
Bartai, T.7
Langel, Ü.8
-
30
-
-
0000154978
-
-
Namikoshi, M. N.; Rinehart, K. L.; Sakai, R.; Stotts, R. R.; Dahlem, A. M.; Beasley, V. R.; Carmichael, W. W.; Evans, W. R. J. Org. Chem. 1992, 57, 866.
-
(1992)
J. Org. Chem.
, vol.57
, pp. 866
-
-
Namikoshi, M.N.1
Rinehart, K.L.2
Sakai, R.3
Stotts, R.R.4
Dahlem, A.M.5
Beasley, V.R.6
Carmichael, W.W.7
Evans, W.R.8
-
31
-
-
0020433194
-
-
(a) Botes, D. P.; Kruger, H.; Viljoen, C. C. Toxicon 1982, 20, 945.
-
(1982)
Toxicon
, vol.20
, pp. 945
-
-
Botes, D.P.1
Kruger, H.2
Viljoen, C.C.3
-
32
-
-
37049095866
-
-
(b) Botes, D. P.; Tuinman, A. A.; Wessels, P. L.; Viljoen, C. C.; Kruger, H.; Williams, D. H.; Santikarn, S.; Smith, R. J.; Hammond, S. J. J. Chem. Soc., Perkin Trans. 1 1984, 2311.
-
(1984)
J. Chem. Soc., Perkin Trans. 1
, pp. 2311
-
-
Botes, D.P.1
Tuinman, A.A.2
Wessels, P.L.3
Viljoen, C.C.4
Kruger, H.5
Williams, D.H.6
Santikarn, S.7
Smith, R.J.8
Hammond, S.J.9
-
33
-
-
0024413642
-
-
(a) Stoner, R. D.; Adams, W. H.; Slatkin, D. N.; Siegelman, H. W. Toxicon 1989, 825.
-
(1989)
Toxicon
, pp. 825
-
-
Stoner, R.D.1
Adams, W.H.2
Slatkin, D.N.3
Siegelman, H.W.4
-
34
-
-
0026644341
-
-
(b) Nishiwaki-Matsushima, R.; Fujiki, H.; Harada, K.; Taylor, C.; Quinn, R. J. Bioorg. Med. Chem. Lett. 1992, 2, 673.
-
(1992)
Bioorg. Med. Chem. Lett.
, vol.2
, pp. 673
-
-
Nishiwaki-Matsushima, R.1
Fujiki, H.2
Harada, K.3
Taylor, C.4
Quinn, R.J.5
-
35
-
-
37049101108
-
-
(a) Botes, P. B.; Wessels, P. L.; Kruger, H.; Runnegar, M. T. C.; Santikarn, S.; Smith, R. J.; Barna, J. C. J.; Williams, D. H. J. Chem. Soc., Perkin Trans. 1 1985, 2747.
-
(1985)
J. Chem. Soc., Perkin Trans. 1
, pp. 2747
-
-
Botes, P.B.1
Wessels, P.L.2
Kruger, H.3
Runnegar, M.T.C.4
Santikarn, S.5
Smith, R.J.6
Barna, J.C.J.7
Williams, D.H.8
-
36
-
-
33749709837
-
-
(b) Rinehart, K. L.; Harada, K.; Namikoshi, M.; Chen, C.; Harvis, C.; Munro, M. H. G.; Blunt, J.; Mulligan, P.; Beasley, V.; Dahlem, A.; Carmichael, W. J. Am. Chem. Soc. 1988, 110, 8557.
-
(1988)
J. Am. Chem. Soc.
, vol.110
, pp. 8557
-
-
Rinehart, K.L.1
Harada, K.2
Namikoshi, M.3
Chen, C.4
Harvis, C.5
Munro, M.H.G.6
Blunt, J.7
Mulligan, P.8
Beasley, V.9
Dahlem, A.10
Carmichael, W.11
-
37
-
-
0026528205
-
-
de Silva, E. D.; Williams, D. E.; Anderson, R. J.; Klix, H.; Holmes, C. F. B.; Allen, T. M. Tetrahedron Lett. 1992, 33, 1561.
-
(1992)
Tetrahedron Lett.
, vol.33
, pp. 1561
-
-
De Silva, E.D.1
Williams, D.E.2
Anderson, R.J.3
Klix, H.4
Holmes, C.F.B.5
Allen, T.M.6
-
39
-
-
0029094754
-
-
Goldberg, J.; Huang, H.; Kwon, Y. G.; Greengard, P.; Nairn, A. C.; Kunyan, J. Nature 1995, 376, 745.
-
(1995)
Nature
, vol.376
, pp. 745
-
-
Goldberg, J.1
Huang, H.2
Kwon, Y.G.3
Greengard, P.4
Nairn, A.C.5
Kunyan, J.6
-
40
-
-
0027254410
-
-
Stotts, R. R., Namikoshi, M.; Haschek, W. M.; Rinehart, K. L.; Carmichael, W. W.; Dahlem, A. M.; Beasley, V. R. Toxicon 1993, 31, 783-789.
-
(1993)
Toxicon
, vol.31
, pp. 783-789
-
-
Stotts, R.R.1
Namikoshi, M.2
Haschek, W.M.3
Rinehart, K.L.4
Carmichael, W.W.5
Dahlem, A.M.6
Beasley, V.R.7
-
43
-
-
33845312505
-
-
(c) Carpino, L. A.; El-Faham, A.; Minor, C. A.; Albericio, F. J. Chem. Soc., Chem. Commun. 1994, 201.
-
(1994)
J. Chem. Soc., Chem. Commun.
, pp. 201
-
-
Carpino, L.A.1
El-Faham, A.2
Minor, C.A.3
Albericio, F.4
-
44
-
-
0028222937
-
-
(d) Carpino, L. A.; El-Faham, A.; Albericio, F. Tetrahedron Lett. 1994, 35, 2279.
-
(1994)
Tetrahedron Lett.
, vol.35
, pp. 2279
-
-
Carpino, L.A.1
El-Faham, A.2
Albericio, F.3
-
47
-
-
0000314051
-
-
(a) Wipf, P. Chem. Rev. 1995, 95, 2115.
-
(1995)
Chem. Rev.
, vol.95
, pp. 2115
-
-
Wipf, P.1
-
48
-
-
0000477615
-
-
(b) Cavelier-Frontin, F.; Pépe, G.; Verducci, J.; Siri. D.; Jacquier, R. J. Am. Chem. Soc. 1992, 14, 8885.
-
(1992)
J. Am. Chem. Soc.
, vol.14
, pp. 8885
-
-
Cavelier-Frontin, F.1
Pépe, G.2
Verducci, J.3
Siri, D.4
Jacquier, R.5
-
50
-
-
0027244347
-
-
(d) Ehrlich, A.; Rothemund, S.; Brudel, M.; Beyermann, M.; Carpino, L. A.; Bienert, M. Tetrahedron Lett. 1993, 34, 4781.
-
(1993)
Tetrahedron Lett.
, vol.34
, pp. 4781
-
-
Ehrlich, A.1
Rothemund, S.2
Brudel, M.3
Beyermann, M.4
Carpino, L.A.5
Bienert, M.6
-
51
-
-
0023872535
-
-
For reviews on dehydro amino acid and peptide synthesis, see: (a) Schmidt, U.; Lieberknecht, A.; Wild, J. Synthesis 1988, 159. (b) Stammer, C. H. In Chemistry and Biology of Amino Acids, Peptides and Proteins; John Wright and Sons: London, 1982: Vol. 6, pp 33-74. (c) α,β-Dehydroamino acids and peptides: Noda, K.; Shimohigashi, Y.; Izumiya, N. In The Peptides, Gross, E., Meienhofer, J., Eds.: Academic Press: New York, 1983; Vol. 5, pp 285-339.
-
(1988)
Synthesis
, pp. 159
-
-
Schmidt, U.1
Lieberknecht, A.2
Wild, J.3
-
52
-
-
0002893709
-
-
John Wright and Sons: London
-
For reviews on dehydro amino acid and peptide synthesis, see: (a) Schmidt, U.; Lieberknecht, A.; Wild, J. Synthesis 1988, 159. (b) Stammer, C. H. In Chemistry and Biology of Amino Acids, Peptides and Proteins; John Wright and Sons: London, 1982: Vol. 6, pp 33-74. (c) α,β-Dehydroamino acids and peptides: Noda, K.; Shimohigashi, Y.; Izumiya, N. In The Peptides, Gross, E., Meienhofer, J., Eds.: Academic Press: New York, 1983; Vol. 5, pp 285-339.
-
(1982)
Chemistry and Biology of Amino Acids, Peptides and Proteins
, vol.6
, pp. 33-74
-
-
Stammer, C.H.1
-
53
-
-
0003175687
-
-
Gross, E., Meienhofer, J., Eds.: Academic Press: New York
-
For reviews on dehydro amino acid and peptide synthesis, see: (a) Schmidt, U.; Lieberknecht, A.; Wild, J. Synthesis 1988, 159. (b) Stammer, C. H. In Chemistry and Biology of Amino Acids, Peptides and Proteins; John Wright and Sons: London, 1982: Vol. 6, pp 33-74. (c) α,β-Dehydroamino acids and peptides: Noda, K.; Shimohigashi, Y.; Izumiya, N. In The Peptides, Gross, E., Meienhofer, J., Eds.: Academic Press: New York, 1983; Vol. 5, pp 285-339.
-
(1983)
The Peptides
, vol.5
, pp. 285-339
-
-
Noda, K.1
Shimohigashi, Y.2
Izumiya, N.3
-
54
-
-
0019982027
-
-
(a) Noda, K.; Gazis, D.; Gross, E. Int. J. Peptide Protein Res. 1982, 19, 413.
-
(1982)
Int. J. Peptide Protein Res.
, vol.19
, pp. 413
-
-
Noda, K.1
Gazis, D.2
Gross, E.3
-
56
-
-
0343480851
-
-
(c) Rich, D. H.; Tam, J.; Mathiaparanam, P.; Grant, J. A. Synthesis 1975, 402.
-
(1975)
Synthesis
, pp. 402
-
-
Rich, D.H.1
Tam, J.2
Mathiaparanam, P.3
Grant, J.A.4
-
57
-
-
33748497013
-
-
(d) Schmidt, U.; Lieberknecht, A.; Schanbacher, U.; Beuttler, T.; Wild, J. Angew. Chem., Int. Ed. Engt. 1982, 21, 770.
-
(1982)
Angew. Chem., Int. Ed. Engt.
, vol.21
, pp. 770
-
-
Schmidt, U.1
Lieberknecht, A.2
Schanbacher, U.3
Beuttler, T.4
Wild, J.5
-
61
-
-
0001587728
-
-
Garcia, J.; Gonzalez, J.; Segura, R.; Vilarrasa, J. Tetrahedron 1984, 40, 3121.
-
(1984)
Tetrahedron
, vol.40
, pp. 3121
-
-
Garcia, J.1
Gonzalez, J.2
Segura, R.3
Vilarrasa, J.4
-
62
-
-
0027505624
-
-
The corresponding diethylphosphonate derivative was prepared previously by a different route: Shankar, R.; Scott, A. I. Tetrahedron Lett. 1993, 34, 231.
-
(1993)
Tetrahedron Lett.
, vol.34
, pp. 231
-
-
Shankar, R.1
Scott, A.I.2
-
66
-
-
0004027063
-
-
Gross, E; Meienhofer, J. Eds.; Academic Press: New York
-
(c) Bodansky, M.; Martinez, J. In The Peptides; Gross, E; Meienhofer, J. Eds.; Academic Press: New York, 1983; Vol. 5.
-
(1983)
The Peptides
, vol.5
-
-
Bodansky, M.1
Martinez, J.2
-
68
-
-
0025313287
-
-
Gmeiner, P.; Feldman, P. L.; Chu-Moyer, M. Y.; Rapoport, H. J. Org. Chem. 1990, 55, 3068.
-
(1990)
J. Org. Chem.
, vol.55
, pp. 3068
-
-
Gmeiner, P.1
Feldman, P.L.2
Chu-Moyer, M.Y.3
Rapoport, H.4
-
69
-
-
10544224689
-
-
note
-
The Fmoc and Cbz derivatives and the corresponding aspartic acid derivatives are available in similar yields by this method. Experimental details will be described elsewhere.
-
-
-
-
73
-
-
0024507836
-
-
(d) Jouin, P.; Poncet, J.; Dufour, M.-N.; Pantaloni, A.; Castro, B. J. Org. Chem. 1989, 54, 617.
-
(1989)
J. Org. Chem.
, vol.54
, pp. 617
-
-
Jouin, P.1
Poncet, J.2
Dufour, M.-N.3
Pantaloni, A.4
Castro, B.5
-
75
-
-
0025868658
-
-
(b) Coste, J.; Frerot, E.; Jouin, P.; Castro, B. Tetrahedron Lett. 1991, 32, 1967.
-
(1991)
Tetrahedron Lett.
, vol.32
, pp. 1967
-
-
Coste, J.1
Frerot, E.2
Jouin, P.3
Castro, B.4
-
76
-
-
0025819848
-
-
For examples of efficient HOBt-induced acylations of secondary amines, see: (a) Chu, K. S.; Negrete, G. R.; Konopelski, J. P. J. Org . Chem. 1991, 56, 5196. (b) White, J. D:. Amedio, J. C. J. Org. Chem. 1989, 54, 736. (c) Grieco, P. A.; Perez-Medrano, A. Tetrahedron Lett. 1988, 29, 4225. (d) reference 24.
-
(1991)
J. Org . Chem.
, vol.56
, pp. 5196
-
-
Chu, K.S.1
Negrete, G.R.2
Konopelski, J.P.3
-
77
-
-
33645672005
-
-
For examples of efficient HOBt-induced acylations of secondary amines, see: (a) Chu, K. S.; Negrete, G. R.; Konopelski, J. P. J. Org . Chem. 1991, 56, 5196. (b) White, J. D:. Amedio, J. C. J. Org. Chem. 1989, 54, 736. (c) Grieco, P. A.; Perez-Medrano, A. Tetrahedron Lett. 1988, 29, 4225. (d) reference 24.
-
(1989)
J. Org. Chem.
, vol.54
, pp. 736
-
-
White, J.D.1
Amedio, J.C.2
-
78
-
-
0023759025
-
-
For examples of efficient HOBt-induced acylations of secondary amines, see: (a) Chu, K. S.; Negrete, G. R.; Konopelski, J. P. J. Org . Chem. 1991, 56, 5196. (b) White, J. D:. Amedio, J. C. J. Org. Chem. 1989, 54, 736. (c) Grieco, P. A.; Perez-Medrano, A. Tetrahedron Lett. 1988, 29, 4225. (d) reference 24.
-
(1988)
Tetrahedron Lett.
, vol.29
, pp. 4225
-
-
Grieco, P.A.1
Perez-Medrano, A.2
-
79
-
-
10544227055
-
-
reference 24
-
For examples of efficient HOBt-induced acylations of secondary amines, see: (a) Chu, K. S.; Negrete, G. R.; Konopelski, J. P. J. Org . Chem. 1991, 56, 5196. (b) White, J. D:. Amedio, J. C. J. Org. Chem. 1989, 54, 736. (c) Grieco, P. A.; Perez-Medrano, A. Tetrahedron Lett. 1988, 29, 4225. (d) reference 24.
-
-
-
-
80
-
-
0011850124
-
-
Diago-Meseguer, J.; Palomo-Col, A. L.; Fernandez-Lizarbe, J. R.; Zugaza-Bilbao, A. Synthesis 1980, 547.
-
(1980)
Synthesis
, pp. 547
-
-
Diago-Meseguer, J.1
Palomo-Col, A.L.2
Fernandez-Lizarbe, J.R.3
Zugaza-Bilbao, A.4
-
82
-
-
0025057125
-
-
(c) Coste, J.; Dufour, M.-N.; Pantaloni, A.; Castro, B. Tetrahedron Lett. 1990, 31, 669.
-
(1990)
Tetrahedron Lett.
, vol.31
, pp. 669
-
-
Coste, J.1
Dufour, M.-N.2
Pantaloni, A.3
Castro, B.4
-
83
-
-
0028200030
-
-
(a) Humphrey, J. M.; Hart, J. A.; Bridges, R. J.; Chamberlin, A. R. J. Org. Chem. 1994, 59, 2467.
-
(1994)
J. Org. Chem.
, vol.59
, pp. 2467
-
-
Humphrey, J.M.1
Hart, J.A.2
Bridges, R.J.3
Chamberlin, A.R.4
-
84
-
-
0029045102
-
-
(b) Humphrey, J. M.; Hart, J. A.; Chamberlin, A. R. Bioorg. Med. Chem. Lett. 1995, 5, 1315.
-
(1995)
Bioorg. Med. Chem. Lett.
, vol.5
, pp. 1315
-
-
Humphrey, J.M.1
Hart, J.A.2
Chamberlin, A.R.3
-
85
-
-
37049105216
-
-
The distal ester of this compound is surprisingly unreactive, presumably due to steric hinderance from the N-phenylfluorenyl and α-methyl groups. The compound does not react with hydrazine in refluxing methanol. The failure of ester hydrazinolysis with hindered substrates has been noted before: Davies, J. S.; Mohammed, A. K. J. Chem. Soc., Perkin Trans. 1 1981, 2982.
-
(1981)
J. Chem. Soc., Perkin Trans. 1
, pp. 2982
-
-
Davies, J.S.1
Mohammed, A.K.2
-
86
-
-
85012326224
-
-
(a) Alanine trichloroethyl ester was prepared through a higher yielding modification of the literature procedure. See Carson, J. F. Synthesis 1979, 24.
-
(1979)
Synthesis
, pp. 24
-
-
Carson, J.F.1
-
87
-
-
0344007217
-
-
(b) Marinier, B.; Kim, Y. C.; Navarre, J.-M. Can. J. Chem. 1973, 51, 208.
-
(1973)
Can. J. Chem.
, vol.51
, pp. 208
-
-
Marinier, B.1
Kim, Y.C.2
Navarre, J.-M.3
-
88
-
-
37049090255
-
-
(a) Beatty, M. F.; Jennings-White, C.; Avery, M. A. J. Chem. Soc., Perkin Trans. 1 1992, 1637.
-
(1992)
J. Chem. Soc., Perkin Trans. 1
, pp. 1637
-
-
Beatty, M.F.1
Jennings-White, C.2
Avery, M.A.3
-
89
-
-
0010620248
-
-
(b) Namikoshi, M.; Rinehart, K. L.; Dahlem. A. M.; Beasley, V. R.; Charmichael, W. W. Tetrahedron Lett. 1989, 30, 4349.
-
(1989)
Tetrahedron Lett.
, vol.30
, pp. 4349
-
-
Namikoshi, M.1
Rinehart, K.L.2
Dahlem, A.M.3
Beasley, V.R.4
Charmichael, W.W.5
-
91
-
-
0022012266
-
-
(a) Miyaura, N.; Yamada, K.; Suginome, H.; Suzuki, A. J. Am. Chem. Soc. 1985, 107, 972.
-
(1985)
J. Am. Chem. Soc.
, vol.107
, pp. 972
-
-
Miyaura, N.1
Yamada, K.2
Suginome, H.3
Suzuki, A.4
-
92
-
-
49249152617
-
-
(b) Miyaura, N.; Yamada, Y.; Suzuki, A. Tetrahedron Lett. 1979, 20, 3437.
-
(1979)
Tetrahedron Lett.
, vol.20
, pp. 3437
-
-
Miyaura, N.1
Yamada, Y.2
Suzuki, A.3
-
93
-
-
0011430062
-
-
(c) Miyaura, N.; Suginome, H.; Suzuki, A. Tetrahedron Lett. 1981, 22, 127.
-
(1981)
Tetrahedron Lett.
, vol.22
, pp. 127
-
-
Miyaura, N.1
Suginome, H.2
Suzuki, A.3
-
94
-
-
33947488929
-
-
Anderson, G. W.: Zimmerman, J. E.; Calahan, F. M. J. Am. Chem. Soc. 1964, 86, 1839.
-
(1964)
J. Am. Chem. Soc.
, vol.86
, pp. 1839
-
-
Anderson, G.W.1
Zimmerman, J.E.2
Calahan, F.M.3
-
96
-
-
0013618401
-
-
and references therein
-
Similar substrates without 2,3-syn substituents appear to lactonize spontaneously. See Baldwin, J. E.; North, M.; Flinn, A. Tetrahedron Lett. 1987, 28, 3167, and references therein.
-
(1987)
Tetrahedron Lett.
, vol.28
, pp. 3167
-
-
Baldwin, J.E.1
North, M.2
Flinn, A.3
-
99
-
-
33845373603
-
-
Takai, K.; Nitta, K.; Ulimoto, K. J. J. Am. Chem. Soc. 1986, 108, 7408.
-
(1986)
J. Am. Chem. Soc.
, vol.108
, pp. 7408
-
-
Takai, K.1
Nitta, K.2
Ulimoto, K.J.3
-
101
-
-
0012016624
-
-
(b) Evans, D. A.; Bartroli, J.; Shih, T. L. J. Am. Chem. Soc. 1981, 103, 2127.
-
(1981)
J. Am. Chem. Soc.
, vol.103
, pp. 2127
-
-
Evans, D.A.1
Bartroli, J.2
Shih, T.L.3
-
102
-
-
0025108083
-
-
Evans, D. A.; Kaldor, S. W.; Jones, T. K.; Clardy, J.; Stout, T. J. J. Am. Chem. Soc. 1990, 112, 7001-7031.
-
(1990)
J. Am. Chem. Soc.
, vol.112
, pp. 7001-7031
-
-
Evans, D.A.1
Kaldor, S.W.2
Jones, T.K.3
Clardy, J.4
Stout, T.J.5
-
106
-
-
33751392144
-
-
Knochel, P.; Tucker, C. E.; Davidson, J. J. Org. Chem. 1992, 57, 3482-3485.
-
(1992)
J. Org. Chem.
, vol.57
, pp. 3482-3485
-
-
Knochel, P.1
Tucker, C.E.2
Davidson, J.3
-
107
-
-
0027421977
-
-
Suzuki, A.; Miyaura, T. N.; Kamabuchi, A. Synth. Commun. 1993, 23, 2851-2859.
-
(1993)
Synth. Commun.
, vol.23
, pp. 2851-2859
-
-
Suzuki, A.1
Miyaura, T.N.2
Kamabuchi, A.3
-
110
-
-
33845281635
-
-
(a) Uenishi, J.; Beau, J.-M.; Armstrong, R. W.; Kishi, Y. J. Am. Chem. Soc. 1987, 109, 4756.
-
(1987)
J. Am. Chem. Soc.
, vol.109
, pp. 4756
-
-
Uenishi, J.1
Beau, J.-M.2
Armstrong, R.W.3
Kishi, Y.4
-
111
-
-
0000795317
-
-
(b) Smith, G. B.; Dezeny, G. C.: Hughes, D. L.; King, A. O.; Verhoeven, T. R. J. Org. Chem. 1994, 59, 8151.
-
(1994)
J. Org. Chem.
, vol.59
, pp. 8151
-
-
Smith, G.B.1
Dezeny, G.C.2
Hughes, D.L.3
King, A.O.4
Verhoeven, T.R.5
-
112
-
-
85082557998
-
-
(a) Schmidt, U.; Utz, R.; Lieberknecht, A.; Griesser, H.; Potzolli, B.; Bahr, J.; Wagner, K.; Fischer, P. Synthesis 1987, 236.
-
(1987)
Synthesis
, pp. 236
-
-
Schmidt, U.1
Utz, R.2
Lieberknecht, A.3
Griesser, H.4
Potzolli, B.5
Bahr, J.6
Wagner, K.7
Fischer, P.8
-
113
-
-
0001087038
-
-
(b) Schmidt, U.; Lieberknecht. A.; Griesser, H.; Talbiersky, J. J. Org. Chem. 1982, 47, 3261.
-
(1982)
J. Org. Chem.
, vol.47
, pp. 3261
-
-
Schmidt, U.1
Lieberknecht, A.2
Griesser, H.3
Talbiersky, J.4
-
114
-
-
10544239284
-
-
The University of California at Irvine, personal communication
-
1H NMR). Assuming it to result from base catalyzed epimerization competing with saponification, we attempted a number of alternative saponification methods but with no success. Cesium carbonate (ref 66a) gave levels of isomerization comparable to those observed with lithium hydroxide, and barium hydroxide gave more isomerization. Lithium hydroperoxide (ref 66b-d) generated only small amounts of the desired product along with multiple side products. The level of isomerization during this step is consistent with levels observed by Schreiber and Valentekovich for the analogous saponification step in their synthesis of motuporin: Dr. Robert J. Valentekovich, The University of California at Irvine, personal communication, 1996.
-
(1996)
-
-
Valentekovich, R.J.1
-
115
-
-
0025970704
-
-
(a) Kaestle, K. L.; Anwer, M. K.; Audhya, T. K.; Goldstein, G. Tetrahedron Lett. 1991, 32, 327.
-
(1991)
Tetrahedron Lett.
, vol.32
, pp. 327
-
-
Kaestle, K.L.1
Anwer, M.K.2
Audhya, T.K.3
Goldstein, G.4
-
116
-
-
0012126879
-
-
(b) Misra, H. K.; Virzi, F.; Hnatowich, D. J.; Wright, G. Tetrahedron Lett. 1989, 30, 1885.
-
(1989)
Tetrahedron Lett.
, vol.30
, pp. 1885
-
-
Misra, H.K.1
Virzi, F.2
Hnatowich, D.J.3
Wright, G.4
-
117
-
-
0025202146
-
-
(c) Lucas, H.; Basten, J. E. M.; van Dither, T. G.: Meuleman, D.; van Aelst, S. F.; van Boeckel, A. A. Tetrahedron 1990, 46, 8207.
-
(1990)
Tetrahedron
, vol.46
, pp. 8207
-
-
Lucas, H.1
Basten, J.E.M.2
Van Dither, T.G.3
Meuleman, D.4
Van Aelst, S.F.5
Van Boeckel, A.A.6
-
119
-
-
79960698472
-
-
1H NMR analysis due to the large HDO solvent peak. The water supression NMR method developed by Shaka eliminated this problem. See: Hwang, T. L.; Shaka, A. J. J. Magn. Reson. Series A 1995, 112, 275.
-
(1995)
J. Magn. Reson. Series A
, vol.112
, pp. 275
-
-
Hwang, T.L.1
Shaka, A.J.2
-
120
-
-
10544244779
-
-
note
-
3 exhibited the presence of one major rotamer and < 10% of a minor one, which began to coalesce at 45 °C.
-
-
-
|