Enzymatic pathway for the bacterial degradation of the cyanobacterial cyclic peptide toxin microcystin LR

Applied and Environmental Microbiology

Volumn 62, Issue 11, 1996, Pages 4086-4094

  Bourne, David G ^a,b   Jones, Gary J ^b   Blakeley, Robert L ^a   Jones, Alun ^a   Negri, Andrew P ^b,c   Riddles, Peter ^b  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b CSIRO   (Australia)

^c AUSTRALIAN INSTITUTE OF MARINE SCIENCE   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; BACTERIAL TOXIN; CYANOGINOSIN LR; CYCLOPEPTIDE; PHOSPHOPROTEIN PHOSPHATASE;

AMINO ACID ANALYSIS; ANIMAL EXPERIMENT; ARTICLE; BACTERIUM CULTURE; BIODEGRADATION; CHROMATOGRAPHY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; MASS SPECTROMETRY; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PURIFICATION; WATER TREATMENT;

ANIMALIA; BACTERIA (MICROORGANISMS); CYANOBACTERIA; GALLUS GALLUS; SPHINGOMONAS;

EID: 0029805739     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/aem.62.11.4086-4094.1996     Document Type: Article

References (30)

1. An, J., and W. W. Carmichael. 1994. Use of a colorimetric protein phosphatase inhibition assay and enzyme linked immuno sorbent assay for the study of microcystins and nodularins. Toxicon 32:1495-1507.
2. Bagu, J. R., F. D. Sonnichsen, D. Williams, R. J. Anderson, B. D. Sykes, and C. F. B. Holmes. 1995. Comparison of the solution structures of microcystin-LR and motuporin. Nature (London) Struct. Biol. 2:114-116.
3. Carmichael, W. W. 1992. Cyanobacteria secondary metabolites - the cyanotoxins. J. Appl. Bacteriol. 72:445-459.
4. Carmichael, W. W. 1194. The toxins of cyanobacteria. Sci. Am. 270:64-72.
5. Carmichael, W. W., C. L. A. Jones, N. A. Mahmood, and W. C. Theiss. 1985. Algal toxins and water based diseases. Crit. Rev. Environ. Control. 15:275-313.
6. Choi, B. W., M. Namikoshi, F. Sun, K. L. Rinehart, W. W. Carmichael, A. M. Kaup, W. R. Evans, and V. R. Beasley. 1993. Isolation of linear peptides related to the hepatotoxins nodularin and microcystins. Tetrahedron Lett. 34:7881-7884.
7. Falconer, I. R. 1991. Tumour promotion and liver injury caused by oral consumption of cyanobacteria. Environ. Toxicol. Water Qual. 6:177-184.
8. Falconer, I. R., and S. K. Yeung. 1992. Cytoskeletal changes in hepatocytes induced by Microcystis trains and their relation to hyperphosphorylation of cell proteins. Chem. Biol. Interact. 81:181-196.
9. Goldberg, J., H. Huang, Y. Kwon, P. Greengard, A. C. Nairn, and J. Kuriyan. 1995. Three-dimensional structure of the catalytic subunit of protein serine/ threonine phosphatase-1. Nature (London) 376:745-753.
10. Harada, K., K. Matsuura, M. Suzuki, M. F. Watanabe, S. Oishi, A. M. Dahlem, V. R. Beasley, and W. W. Carmichael. 1990. Isolation and characterisation of the minor components associated with microcystin LR and RR in the cyanobacterium (blue-green algae). Toxicon 28:55-64.
11. Jones, G. J., D. G. Bourne, R. L. Blakeley, and H. Doelle. 1994. Degradation of the cyanobacterial hepatotoxin microcystin by aquatic bacteria. Nat. Toxins 2:228-235.
12. Jones, G. J., I. F. Falconer, and R. M. Wilkins. 1995. Persistence of the cyclic peptide toxins in dried cyanobacterial crusts from Lake Mokoan, Australia. Environ. Toxicol. Water Qual. 10:19-24.
13. Jones, G. J., and P. T. Orr. 1994. Release and degradation of microcystin following algicide treatment of a Microcystis aeruginosa bloom in a recreational lake, as determined by HPLC and protein phosphatase inhibition assay. Water Res. 28:871-876.
14. Krishnamurthy, T., W. W. Carmichael, and E. W. Sarver. 1986. Toxic peptides from freshwater cyanobacteria (blue-green algae). I. Isolation and purification of peptides from Microcystis aeruginosa and Anabaena flos-aquae. Toxicon 24:865-873.
15. Krishnamurthy, T., L. Szafraniec, D. F. Hunt, J. Shabanowitz, J. R. Yates, C. R. Hauer, W. W. Carmichael, O. Skulberg, G. A. Codd, and S. Missler. 1989. Structural characterization of toxic cyclic peptides from blue-green algae by tandem mass spectrometry. Proc. Natl. Acad. Sci. USA 86:770-774.
16. Lam, A. K. Y., P. M. Fedorak, and E. E. Prepas. 1995. Biotransformation of the cyanobacterial hepatotoxin microcystin LR, as determined by HPLC and protein phosphatase bioassay. Environ. Sci. Technol. 29:242-246.
17. Mackintosh, C., K. A. Beattie, S. Klumpp, P. Cohen, and G. A. Codd. 1990. Cyanobacterial microcystin LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants. FEBS Lett. 264:187-192.
18. Moorhead, G., R. W. Mackintosh, N. Morrice, T. Gallagher, and C. Mackintosh. 1994. Purification of type 1 protein (serine/threonine) phosphatases by microcystin-Sepharose affinity chromatography. FEBS Lett. 356:46-50.
19. Namikoshi, M., K. L. Rinehart, and R. Sakai. 1992. Identification of 12 hepatotoxins from Homer Lake bloom of cyanobacteria Microcystis aeruginosa, Microcystis viridis, and Microcystis wesenbergii: nine new microcystins. J. Org. Chem. 57:866-872.
20. Neurath, H. 1982. The diversity of proteolytic enzymes, p. 1-12. In R. J. Beynon and J. S. Bond (ed.), Proteolytic enzymes: a practical approach. IRL Press, Oxford.
21. Nishiwaki-Matsushima, R., T. Ohta, S. Nishiwaki, M. Suganuma, K. Kohyama, T. Ishikawa, W. W. Carmichael, and H. Fujike. 1992. Liver tumor promotion by the cyanobacterial cyclic peptide toxin microcystin-LR. J. Cancer Res. Clin. Oncol. 118:420-424.
22. North, M. J. 1982. Comparative biochemistry of the proteinases of eucaryotic microorganisms. Microbiol. Rev. 46:308-340.
23. Rapala, J., K. Lahti, K. Sivonen, and S. I. Niemela. 1994. Biodegradability and adsorption on lake sediments of cyanobacterial hepatotoxins and anatoxin-a. Lett. Appl. Microbiol. 19:423-428.
24. Rinehart, K. L., M. Namikoshio, and B. W. Choi. 1994. Structure and biosynthesis of toxins from blue-green algae (cyanobacteria). J. Appl. Phycol. 6:159-176.
25. Rudolf-Bohner, S., D. F. Mierke, and L. Moroder. 1994. Molecular structure of the cyanobacterial tumour-promoting microcystins. FEBS Lett. 349:319-323.
26. Salvesen, G., and H. Nagase. 1982. Inhibition of proteolytic enzymes, p. 83-102. In R. J. Beynon and J. S. Bond (ed.), Proteolytic enzymes: a practical approach. IRL Press, Oxford.
27. Shun-Zhang, Y. 1989. Drinking water and primary liver cancer, p. 30. In Z. G. Tang, M. C. Wu, and S. S. Xia (ed.), Primary liver cancer. Springer-Verlag, Berlin.
28. Sivonen, K., M. Namikoshi, W. R. Evans, W. W. Carmichael, F. Sun, L. Rouhiainen, R. Luukkainen, and K. L. Rinehart. 1992. Isolation and characterization of a variety of microcystins from seven strains of the cyanobacterial genus Anabaena. Appl. Environ. Microbiol. 58:2495-2500.
29. Yoshizawa, S., R. Matsushima, M. F. Watanabe, K. Harada, A. Ichihara, W. W. Carmichael, and H. Fujiki. 1990. Inhibition of protein phosphatases by microcystin and nodularin associated with hepatotoxicity. J. Cancer Res. Clin. Oncol. 116:609-614.
30. Zhang, Z., S. Zhao, S. Deans-Zirattu, G. Bai, and E. Y. C. Lee. 1993. Mutagenesis of the catalytic subunit of rabbit muscle protein phosphatase-1. Mol. Cell. Biochem. 128:113-119.