-
2
-
-
0010521980
-
-
note
-
3. Microcystins in which the glutamic acid carboxyl residue of microcystin LR Ib has been esterified are essentially non-toxic when compared to microcystin LR Ib in the same laboratory animal study. See ref. 2 and references cited therein.
-
-
-
-
3
-
-
0010446409
-
-
note
-
4. Microcystins related to microcystin LR Ib in which the C-9 methoxy group of the ADDA residue is replaced with hydroxy or acetoxy show slightly reduced toxicity in laboratory animal tests. Microcystins or nodularins in which the C-6,7 double bond of the ADDA residue has been isomerised to the Z-isomer are essentially non-toxic in the same animal study. See ref. 2 and references cited therein.
-
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4
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0029094754
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5. Goldberg, J., Huang, H., Kwon, Y., Greengard, P., Nairn, A.C. and Kuriyan, J. Nature, 1995, 376, 745.
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5
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0000727123
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6. The use of activated β-lactams in amide bond formation has been reviewed. Ojima, I. and Delaloge, F. Chem. Soc. Rev., 1997, 26, 377.
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7
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33947467241
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8. Prepared by the method described for the S-enantiomer. Zervas, L. Winitz, M. and Greenstein, J.P. J. Am. Chem. Soc., 1957, 79, 1515.
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9. Baldwin, J.E., Adlington, R.M., Gollins, D.W. and Schofield, C.J. Tetrahedron, 1990, 46, 4733 and references.
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9
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4243967712
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PhD thesis, Oxford University, 1990. We thank Prof. E.J. Thomas (Manchester, UK) for providing extracts from this thesis and Prof A. Kende (Rochester, USA) for providing unpublished experimental details
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10. Chem. Abs. 116: 20822m. Roe, J.M., PhD thesis, Oxford University, 1990. We thank Prof. E.J. Thomas (Manchester, UK) for providing extracts from this thesis and Prof A. Kende (Rochester, USA) for providing unpublished experimental details.
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0010441860
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1H n.m.r. of alcohol 15
-
1H n.m.r. of alcohol 15
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-
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26
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33947085552
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(b) The enantiomeric excess of alcohol 15 was determined by Mosher's method [J. Am. Chem. Soc. 1973, 95, 512].
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27
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26844568935
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(c) See also; Blakemore, P.R., Cole, W.J., Kocienski, P.J. and Morley, A. Synlett, 1998, 26 and references for related work.
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31
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0010444302
-
-
E,E-4 was separated from E,Z-4 by careful silica gel chromatography
-
20. E,E-4 was separated from E,Z-4 by careful silica gel chromatography.
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32
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0028076811
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